Archives—June 2016

Tumban lab MiCup poster presentation

 

Ebenezer Tumban portriat
Ebenezer Tumban

Kambrie Boomgaard (Grand Rapids Community College) will be presenting a poster based on research in Dr. Ebenezer Tumban’s research lab.

Her title and abstract are:

Assessing the Solubility of Recombinant Bacteriophage  L2 Coat Proteins in Two Bacterial Strains

Kambrie Boomgaard1,, Lukai Zhai2, Ebenezer Tumban2

 

1Grand Rapids Community College,  2Department of Biological Sciences, Michigan Technological University

Abstract:

Currently, there are about 19 human papillomavirus (HPV) types that can cause cervical, penile, and anal cancers. A Second-generation HPV vaccine (Gardasil-9) has been approved to protect against more HPV types. However, the vaccine is going to protect against HPV types that cause only 86-90% of HPV-associated cervical and penile cancers. Complete protection from all HPV-associated cancers requires the addition of HPV L1 capsid from all cancer-causing HPVs. As an alternative approach to L1, we targeted conserved epitopes on L2 capsid protein to elicit broad protection against more HPV types. We developed bacteriophage (phage) MS2 and AP205 virus-like particles (VLPs) displaying a conserved L2 epitope and consensus epitopes from the L2 of all cancer-causing HPV types. Although some of the L2-phage coat proteins assembled efficiently into VLPs, the assembly of other L2-phage coat proteins were sub-optimal. The main goal of this research was to assess if the solubility and assembly of the sub-optimal L2-phage coat proteins could be enhanced by expressing the proteins in two different bacterial strains and at different temperatures. Our preliminary results show that AP205 displaying L2 is expressed and is soluble in Origami cells induced at 37 °C.

MiCUP Poster Presentation

by Center for Diversity and Inclusion

Join the Center for Diversity and Inclusion from 3 to 5 p.m. Thursday June 16, in MUB Ballroom A where students from Delta College, Grand Rapids Community College and Wayne County Community College who have been participating theMiCUP Residential Summer Research Program will present posters.

Join in a celebration of their accomplishments. This event is free and open to the public. Refreshments will be served.

For more information email Kellie Raffaelli.

Top 10% Biological Sciences Instructors in Spring 2016

 

Fay teaching
Karyn Fay is showing a student a lab technique

Dr. Joshi congratulates the top 10% Biological Sciences instructors in spring 2016:

Heartiest congratulations to the following faculty and graduate students from Biological Sciences Department who have been identified as one of only 85 campus-wide instructors who received an exceptional “Average of 7 dimensions” student evaluation scores during Spring 2016 semester. Their scores were in the top 10% of similarly sized sections university-wide that had at least a 50% response rate.

Provost Jacqueline Huntoon recently congratulated them for their outstanding accomplishments in teaching.

The following faculty received scores above 4.63 out of 5 on average of 7 elements of university-wide class size group with response rate of >50% on student evaluations of their lecture classes:

  • Dr. Amy Marcarelli, Associate Professor
  • Ms. Brigitte Morin, Lecturer
  • Ms. Karyn Fay, Professor of Practice (Winner of teaching award in 2016)
  • Dr. Thomas Werner, Assistant Professor (Winner of teaching award in 2013)

The following instructors received scores above 4.76 out of 5 on “average of 7 elements” of university-wide class size group with response rate of >50% on student evaluations of their classes:

  • Jeff Kiiskila, Graduate Student Instructor
  • Dr. Michelle Seguin, Instructor

Shekhar


Robert Larson awarded AAS-Lundbeck Research Fellowship


Robert-LarsonRobert Larson
, PhD student in Biological Sciences, has been awarded the 2016  AAS-Lundbeck Research Fellowship as announced on their website.   His research is titled ” Targeting Cardiac Sympathetic and Renin Angiotensin Systems with Ang-(1-7) in Hypertrophic Cardiomyopathy” which will be completed in the Department of Internal Medicine at The University of Iowa Carver College of Medicine with Dr. Mark Chapleau.

The Summary of his research:

Hypertrophic cardiomyopathy (HCM) is a relatively common inherited disease characterized by cardiac hypertrophy (enlarged heart), fibrosis, and dysfunction. Patients with HCM exhibit abnormal neural reflex control of blood pressure and heart rate, and are at high risk of developing heart failure, arrhythmias and sudden cardiac death. Current treatment strategies primarily target symptoms and not development of the disease. We propose a novel treatment strategy with Angiotensin-(1-7), a peptide known to diminish sympathetic nerve activity and the pro-fibrotic and pro-hypertrophic actions of angiotensin II. We hypothesize that a combination of sustained inhibition of cardiac sympathetic activity and inhibition of adverse cardiac actions of angiotensin II will act synergistically to prevent or reverse cardiac fibrosis, hypertrophy and arrhythmias in HCM. We will test this hypothesis using an established mouse model of HCM, in which a human mutation is targeted selectively to the heart.

Robert will be completing his degree under Kineseology and Integrative Physiology Adjunct Professor Qing-Hui Chen this summer.

Congratulations from Biological Sciences!