Category: Graduate Student

In Print: Erika Hersch-Green and Angela Walczyk

Congratulations to Dr. Angela Walczyk (recent Ph.D. from Biological Sciences) and her advisor Dr. Erika Hersch-Green for their two new publications! You can access the papers here:

Erika Hersch-Green
Erika Hersch-Green

1. Exciting findings that genome size can affect resource requirements and genomic/transcriptomic functional trait trade-offs. 

Abstract

Premise: Increased genome-material costs of N and P atoms inherent to organisms with larger genomes have been proposed to limit growth under nutrient scarcities and to promote growth under nutrient enrichments. Such responsiveness may reflect a nutrient-dependent diploid versus polyploid advantage that could have vast ecological and evolutionary implications, but direct evidence that material costs increase with ploidy level and/or influence cytotype-dependent growth, metabolic, and/or resource-use trade-offs is limited.

Methods: We grew diploid, autotetraploid, and autohexaploid Solidago gigantea plants with one of four ambient or enriched N:P ratios and measured traits related to material costs, primary and secondary metabolism, and resource-use.

Results: Relative to diploids, polyploids invested more N and P into cells, and tetraploids grew more with N enrichments, suggesting that material costs increase with ploidy level. Polyploids also generally exhibited strategies that could minimize material-cost constraints over both long (reduced monoploid genome size) and short (more extreme transcriptome downsizing, reduced photosynthesis rates and terpene concentrations, enhanced N-use efficiencies) evolutionary time periods. Furthermore, polyploids had lower transpiration rates but higher water-use efficiencies than diploids, both of which were more pronounced under nutrient-limiting conditions.

Conclusions: N and P material costs increase with ploidy level, but material-cost constraints might be lessened by resource allocation/investment mechanisms that can also alter ecological dynamics and selection. Our results enhance mechanistic understanding of how global increases in nutrients might provide a release from material-cost constraints in polyploids that could impact ploidy (or genome-size)-specific performances, cytogeographic patterning, and multispecies community structuring.

Angela Walczyk
Angela Walczyk

2. Finding that tetraploid Giant Goldenrods may be pre-adapted to be good invaders but that polyploidy per se does not increase phenotypic plasticity. 

Abstract

Polyploidy commonly occurs in invasive species, and phenotypic plasticity (PP, the ability to alter one’s phenotype in different environments) is predicted to be enhanced in polyploids and to contribute to their invasive success. However, empirical support that increased PP is frequent in polyploids and/or confers invasive success is limited. Here, we investigated if polyploids are more pre-adapted to become invasive than diploids via the scaling of trait values and PP with ploidy level, and if post-introduction selection has led to a divergence in trait values and PP responses between native- and non-native cytotypes. We grew diploid, tetraploid (from both native North American and non-native European ranges), and hexaploid Solidago gigantea in pots outside with low, medium, and high soil nitrogen and phosphorus (NP) amendments, and measured traits related to growth, asexual reproduction, physiology, and insects/pathogen resistance. Overall, we found little evidence to suggest that polyploidy and post-introduction selection shaped mean trait and PP responses. When we compared diploids to tetraploids (as their introduction into Europe was more likely than hexaploids) we found that tetraploids had greater pathogen resistance, photosynthetic capacities, and water-use efficiencies and generally performed better under NP enrichments. Furthermore, tetraploids invested more into roots than shoots in low NP and more into shoots than roots in high NP, and this resource strategy is beneficial under variable NP conditions. Lastly, native tetraploids exhibited greater plasticity in biomass accumulation, clonal-ramet production, and water-use efficiency. Cumulatively, tetraploid S. gigantea possesses traits that might have predisposed and enabled them to become successful invaders. Our findings highlight that trait expression and invasive species dynamics are nuanced, while also providing insight into the invasion success and cyto-geographic patterning of S. gigantea that can be broadly applied to other invasive species with polyploid complexes.

New Funding: Amy Marcarelli and Michelle Kelly

Amy Marcarelli is the principal investigator (PI) on a project that has received a $300,000 research and development grant from the National Science Foundation.

The project is titled “MSA: Quantifying whole-stream denitrification and nitrogen fixation with integrated modeling of N2 and O2 fluxes.”

Michelle Kelly is a co-PI on this potential two-year project.

Amy is an ecosystem ecologist with interests in energy and biogeochemical cycles in freshwaters. Her research program blends basic and applied research and integrates across aquatic habitats, including streams, rivers, wetlands, lake littoral zones, and the nearshore regions of the Great Lakes. Dr. Marcarelli’s past and future research trajectory is governed by an interest in understanding the role of small, poorly quantified fluxes or perturbations on ecosystem processes and in linking those ecosystem processes to the underlying structure of microbial, algal, macrophyte, and animal communities.

Congratulations Dr. Marcarelli and Michelle Kelly!

Amy Marcarelli
Amy Marcarelli
Michelle Kelly
Michelle Kelly

Catherine Rono Receives 2023 Songer Research Award

Matthew Songer (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA). This will be used to support a research project competition, the Songer Research Award for Human Health, for undergraduate and graduate students. Remembering their own eagerness to engage in research during their undergraduate years, the Songers established these awards to stimulate and encourage opportunities for original research by current Michigan Tech students. This is the sixth year of the competition.

Students may propose an innovative medically-oriented research project in any area of human health. The best projects will demonstrate the potential to have a broad impact on improving human life. This research will be pursued in consultation with faculty members within the College of Sciences and Arts. The Songers’ gift will support one award for undergraduate research ($4,000) and a second award for graduate research ($6,000). Matching funds from the College will allow two additional awards.

Catherine Rono
Catherine Rono

What are you studying and why?

I am currently pursuing a Ph.D. in Biological Sciences with a specialization in Cancer Biology. My decision to focus on Cancer Biology stems from a profound passion and unwavering interest in cancer research. I strongly believe that advancing scientific knowledge in this field is crucial for improving human health and making a significant impact on society.

Having witnessed the devastating effects of cancer firsthand, I was deeply motivated to dedicate my career to understanding and combating this disease. The global impact of cancer and the challenges it presents have only intensified my determination to make a meaningful difference in the lives of those affected. Being part of the scientific community and working towards finding solutions to this global health concern is both a privilege and a responsibility that I take to heart.

Are you getting the award to continue your research?

I am truly honored to be selected as the recipient of the 2023 Songer Research Award for Human Health in the amount of $6,000. This prestigious award will support my research that aims to understand the mechanisms associated with the loss of Liver Kinase B1 (LKB1) function in Non-Small Cell Lung Cancer (NSCLC). Specifically, I aim to examine the effect of LKB1 loss in sensitizing NSCLC cell lines to Phosphodiesterases 3A (PDE3A) modulators and its role in tumorigenesis. Through these investigations, I hope to uncover valuable insights that will aid in proposing novel biomarker candidates for the treatment of patients with LKB1-deficient cancers. Ultimately, this study will help to contribute to the advancement of personalized and effective therapeutic approaches.

What does the Songer Award mean to you?

This prestigious award holds immense significance for me as it validates the importance of my research and also provides the necessary resources to further contribute to this vital field of study.

I would like to extend my sincere appreciation to Matthew Songer and Laura Songer for their generous donation and their commitment to supporting groundbreaking research in human health. The confidence and trust that has been placed in me through this award inspires me to push the boundaries of scientific exploration and strive for excellence in my work.

I would also like to express my gratitude to the esteemed panel of judges and reviewers who evaluated the applications. Their time, expertise, and dedication are greatly appreciated.

Lastly, I am indebted to my mentor, colleagues, research team, and the entire Biological Sciences Department for their guidance, encouragement, and invaluable contributions. Their support has been instrumental in the progress I have made thus far. I look forward to their continued collaboration as I continue with my research journey.

Catherine Rono is an HRI Fellowship Winner

Catherine Rono HRI Fellowship
Catherine Rono HRI Fellowship Winner

Ph.D. Student in Biological Sciences, Catherine Rono, continues to be recognized for excellence. Rono is the winner of the Summer 2023 HRI Graduate Student Fellowship.

Rono stood out among the applicants. Rono published a first-author peer-reviewed article, “A dynamic compartment model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake in Arabidopsis,” following her undergraduate years at Spelman College. She also won several awards and scholarships.

“The proposal is to screen essential molecules that work together with PDE3-modulator to induce apoptosis of LKB1-mutated tumor cells and to understand the molecular mechanism. The findings are likely useful for precise applications of target therapy relating to the LKB1-regulated cellular metabolisms,” said the award committee. “The project is clearly laid out.”

Health Research Institute (HRI) Graduate Fellowships were created to assist with the cost of graduate studies. Fellowships are awarded three times per year in the Fall, Spring, and Summer terms, with a limit of one award per student of up to $5000 to be used in one semester. 

What are you studying and why?

I am currently pursuing a Ph.D. in Biological Sciences with a focus on Cancer Biology. My decision to focus on this field is deeply rooted in a personal experience I had during my childhood, where I witnessed my beloved aunt battle against ovarian cancer, which tragically claimed her life. This traumatic event left an indelible mark on me and sparked an unwavering passion to make a meaningful contribution to cancer research.

Through my research, I aim to uncover the complexities of this disease and develop innovative approaches for its diagnosis, treatment, and prevention. I hope to contribute to the growing body of knowledge in the field of cancer, working towards improved patient outcomes and, ultimately, a future where cancer is no longer a devastating threat. It is my firm belief that by dedicating myself to this field, I can honor the memory of my aunt and positively impact the lives of countless individuals and families affected by cancer.

Do you plan to continue research with this award?

I am incredibly grateful and honored to have been chosen as the recipient of the Summer 2023 HRI Graduate Fellowship award in the amount of $5,000. This prestigious recognition will provide invaluable support for my research work focused on exploring and uncovering novel metabolic components and biomarkers within the Liver Kinase B1 (LKB1) signaling pathway.

Through rigorous experimentation and analysis, I aim to elucidate the regulatory functions of LKB1 in suppressing the expression of key proteins associated with promoting apoptosis. By unraveling these intricate mechanisms, my research findings have the potential to make substantial contributions to the development of targeted therapies, and personalized medicine approaches for the treatment of patients with LKB1 mutated cancers. The ability to tailor treatments to individual patients based on their specific genetic profiles and molecular characteristics holds great promise for improving patient outcomes and reducing the burden of cancer worldwide.

What does the HRI Fellowship mean to you?

The HRI Graduate Fellowship award is a tremendous honor and a testament to the significance and potential impact of my research work. It not only acknowledges the value of my research but also provides the necessary resources and connections to further drive my work forward. I am deeply grateful for this recognition and committed to utilizing this opportunity to make a meaningful and lasting impact in the field of cancer research.

Furthermore, I would like to express my deepest appreciation to the entire HRI community, my mentor, my colleagues, the research team, and the Biological Sciences Department. I am truly fortunate to be surrounded by such brilliant and dedicated individuals. Their encouragement and support have been instrumental in my growth as a researcher.

Call for Applications: 2023 Songer Research Award for Human Health

Matthew Songer, (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA) to support a research project competition, the Songer Research Award for Human Health, for undergraduate and graduate students. Remembering their own eagerness to engage in research during their undergraduate years, the Songers established these awards to stimulate and encourage opportunities for original research by current Michigan Tech students.

Students may propose an innovative medically-oriented research project in any area of human health. The best projects will demonstrate the potential to have a broad impact on improving human life. This research will be pursued in consultation with faculty members within the College of Sciences and Arts. The Songers’ gift and matching funds from the College will support two awards for undergraduate research ($4,000) and two for graduate research ($6,000), for research conducted over the Summer of 2023 and/or the following academic year.

Learn more about who is eligible to apply, how to apply, and how the funds may be used.

Submit applications as a single PDF file to the Office of the College of Sciences and Arts by 4:00 p.m. Monday, April 24, 2023. Applications may be emailed to djhemmer@mtu.edu. Any questions may be directed to David Hemmer (djhemmer@mtu.edu).

Alumni Stories: Manas Warke, PhD, Biological Sciences, Now a Postdoctoral Fellow

Manas Warke graduated from Michigan Tech with his PhD in Biological Sciences in 2022. He is now a postdoctoral fellow at the University of Cincinnati. Manas is currently working on a USEPA project titled: Unregulated Organic Chemicals in Biosolids: Prioritization, Fate, and risk evaluation for land applications. In addition, he’s working with a startup, Phytobox, to implement phytoremediation to clean up polluted water and make it potable. We had a chance to learn more about Manas and his experience at Michigan Tech.

Where are you from?

Manas working in the lab
Manas doing RNA extractions in the COVID lab

Mumbai, India

Where did you do your undergraduate studies, what did you major in, and when did you graduate with your undergrad?

Bachelors in biotechnology from Mumbai University. I graduated in 2017.

Why did you choose to study at Michigan Tech? 

I was working on my master’s degree when I learnt about a PhD opening in Dr. Datta’s lab. I chose to study at Michigan Tech because of the opportunities it offered with great labs, research, funding and overall environment.

What are you doing now? 

I am working as a postdoctoral fellow at the University of Cincinnati in the Department of Chemical and Environmental Engineering

What do you enjoy most about your postdoctoral fellowship? 

I like how I can conduct independent research based on the knowledge and skills I learned at Michigan Tech—meeting new scientists and networking to learn about the exciting research around campus. I also mentor a few students in the lab and the department. The most important is the work-life balance that comes with a postdoc. Since the hours are flexible, I get time to pursue my hobbies, take breaks and spend time with friends.   

Manas standing by grass on a porch of a house
Manas in San Antonio with the Vetiver grass for Lead pytoremediation

How did your degree and course of study at Michigan Tech prepare you for success? 

Biological Sciences trains you to be a professional in many fields. The research and opportunities Michigan Tech has provided have prepared me to excel in the research field. The excellent lab facilities and collaborative environment at Michigan Tech and the Department of Biological Sciences allowed me to pursue more diverse research and learn many skills. My advisor, Dr. Datta, always encouraged new ideas and thought of better approaches to develop exciting project ideas.

What piece of advice would you give to an undergraduate looking to go to grad school? 

If you’re passionate about a specific research field, go for it. It is okay to be unsure of what you want to do next. Ask a lot of questions, even though they seem irrelevant. Always try to meet new people, especially fellow grad students, and colleagues, as they could be friends and potential future collaborators. Participating in research competitions, conferences, and presentations is an excellent way to build a network and know people with the same interests.   

How would you change the world with the knowledge you have acquired?

Use my knowledge to tackle global problems of soil and water pollution that pose a significant risk to human health. Share my experience and research to create awareness and advocate for issues like environmental health by participating in local and national events. Actively conduct research that positively impacts society and develop innovative solutions. And lastly, volunteer for non-profits, charities, and community organizations.

Outstanding Scholarship Award: Catherine Rono

Catherine Rono
Catherine Rono

Congratulations to Catherine Rono, graduate student in Biological Sciences, for the Outstanding Scholarship Award recognizing her academic performance! Catherine is working towards her PhD in Biological Sciences.

Exceptional graduate students may be nominated by their program or department for the Dean’s Award for Outstanding Scholarship in the year of their graduation. Nominees will have demonstrated academic or professional qualities that set them apart within their academic program. Nominations are made each fall and spring semester.

From Catherine: I would like to express my sincere gratitude to Dr. Joshi, Dr. Huckins, Ms. Tori and the entire Biological Sciences Department for this recognition and nomination to receive the award. Thank you so much Dr. Mark for your constant support and guidance. Thank you for challenging me to get out of my comfort zone and be better. 

Outstanding Scholarship Award: Laura Schaerer

Laura Schaerer

Congratulations to Laura Schaerer, a graduate student in Biological Sciences, for her Outstanding Scholarship Award recognizing her academic performance! Laura is working towards her PhD in Biological Sciences.

Exceptional graduate students may be nominated by their program or department for the Dean’s Award for Outstanding Scholarship in the year of their graduation. Nominees will have demonstrated academic or professional qualities that set them apart within their academic program. Nominations are made each fall and spring semester.

From Laura: Thank you to the Biology department for their nomination, this is a very happy surprise!

Rashi Yadav, Biological Sciences Graduate Student Spotlight

Rashi Yadav is a final year PhD candidate in Department of Biological Sciences working on L2-based virus-like particles (VLPs) against Human Papillomavirus (HPV) and also, production of thermostable VLP platform. In addition to research, she has taught Molecular Biology, Biochemistry, Environmental Microbiology and General Biology as a Graduate Teaching Assistant.

Rashi presenting

HPVs are associated with 90% of cervical cancer and 25% of oral cancer. Infected individuals clear the infection within two years, however persistent infection can lead to cancer and genital warts. Fortunately, there are two L1- based prophylactic vaccine against HPVs that offers protection against 7 cancer causing HPV types (high-risk HPVs) and 2 low risk HPV types that can cause cutaneous and genital warts. However, there are 19 cancer causing HPV types and current vaccine offer limited cross protection. The outer shell (capsid) of HPV is made of two proteins- major capsid protein (L1) that is not conserved and minor capsid protein (L2), on the contrary, is conserved among different types of HPVs. Rashi’s research is focused on assessing the ability of L2-based VLPs against different types of high-risk and low-risk HPV types. Overall, L2-based VLPs can protect against 12 oncogenic HPV types causing cervical and oral cancer in addition to protection against HPV 5 that causes Epidermodysplasia Verruciformis. Rashi’s second project is on development of novel thermostable VLP platform that can be exploited to expose antigens on the surface against cancer or virus as vaccine.

Rashi working in the Covid-19 diagnostic lab.

Rashi won the first prize in 3 Minute Thesis organized by Health Research Slam where students from various departments participated and was awarded a check of $300. The topic of her presentation was “”Oral immunization with bacteriophage MS2-L2 VLPs protects against oral infection with multiple HPV types associated with head and neck cancers ”

Rashi is also working in MTU Covid-19 diagnostic lab. She is one of the few students who joined the lab and helped set up the lab including training and supervising students in RNA extraction of samples. She also prepares viral transport media which is exported to number of health facilities around the city to obtain samples for testing.

Students Earn Honorable Mention in 2020 Virtual Michigan Physiological Society Annual Conference

The first ever Michigan Physiological Society Virtual Conference just wrapped up! It was a great collection of speakers with impressive work. Several of our students and faculty participated, including two students from Dr. John J. Durocher’s research group that earned awards for their presentations!

Thomas Basala (Undergraduate Student, Biological Sciences) earned an honorable mention for his presentation: “Applied Human Physiology Fitness Trail Project: Benefits for Local Residents and Undergraduate Students.”

Aditi Vyas (PhD Student, Biological Sciences) also earned an honorable mention for her presentation: “Effects of 8-Week Active Mindfulness and Stress Management on Anxiety and Mental Health During the Covid-19 Pandemic.”

Congratulations, Thomas and Aditi!

Zoom meeting screenshot of participants.

Thomas Basala research poster

Aditi Vyas research poster