Biomedical Engineering Seminar: Capacitive Micro Machined Ultrasonic Transducers and Systems for Imaging and Surgery

Biomedical Engineering Seminar:
Jingkuang Chen, PhD, Principle Engineer, Johnson & Johnson
Thursday, February 12th, 11:00am, Fisher 132
“Capacitive Micro Machined Ultrasonic Transducers and Systems for Imaging and Surgery”
Sponsored by the Department of Biomedical Engineering

Abstract
This talk will highlight the development of capacitive micromachined ultrasonic transducer (CMUT) arrays for clinical use that delivers diagnostic information, including anatomy images with a better contrast and resolution, as well as therapeutic and surgical functions not available from conventional piezoelectric tools. Examples of these devices include a tiny panoramic CMUT endoscope integrated with high-intensity focused ultrasound capability for arrhythmia diagnosis and surgery, a needle-shaped CMUT array that is smaller than a human hair for imaging, brain blood-flow-rate measurement, or hearing aids, and a CMUT photoacoustic imager. Using photon-induced acoustic waves for image reconstruction, photoacoustic imaging can capture images of blood and calcification cluster, and is exceptionally useful for identifying diseases/abnormalities related to blood, such as internal bleeding from pre-stroke or early-stage cancer. A novel architecture for photoacoustic imaging has been developed allowing light illumination through an infrared-transparent CMUT array, resulting in a compact portable modality suitable for ambulance and other field use. A broader spectrum on the clinical use of
CMUT technology will also be discussed, including the concept of wearable ultrasound patch for soft/hard tissue regeneration or wound healing.

Biomedical Engineering Seminar: Medical Devices and Technology

Biomedical Engineering Seminar: Smita Rao, PhD
Department of Electrical Engineering, University of Texas Arlington,
Sponsored by the Department of Biomedical Engineering
Thursday, February 5th, 3:00pm, Dillman 320

Title: “Medical Devices and Technology”

Abstract
The recent advances in fabrication, design and simulation and ease of access to novel techniques have driven the advances in medical devices and technologies. There is a rise in the demand for wearable or minimally invasive interventions and therapies to improve the day-to-day life of a patient. Currently, several treatment modalities suffer from the need for bulky bedside equipment that limit mobility and hamper quality of life. The cost of such care is also significant. By reducing the size of the devices, making them battery operated or wireless improves the quality of life at a fraction of the cost. In many cases, the device can be implanted in a simple outpatient procedure lowering recovery times and risks associated with post-operation infections. New and innovative diagnostic methodologies, significantly smaller device footprints and lower cost of fabrication using existing techniques have yielded promising results. Implantable wireless, batteryless sensor for gastro-esophageal reflux disease, wirelessly powered gastrostimulators, miniature nanorod sensors for detecting neuro-transmitters such as dopamine have been demonstrated. Another aspect of these advances is in the field of lab-on-chip technologies for
diagnostic applications. Microfluidics has been in the forefront of this effort and continues to provide invaluable information. Microfluidic platforms to study biological phenomenon such as cell proliferation, migration and interaction promise to yield vital clues to the development and spread of diseases like cancer, study the interaction of drugs and explore the bio-mechanic aspects of tissues.

Biomedical Engineering Seminar: Capacitive Micromachined Ultrasonic Transducers and Systems for Imaging and Surgery

Biomedical Engineering Seminar: Jingkuang Chen, Phd
Johnson & Johnson, Ortho Clinical Diagnostics
“Capacitive Micromachined Ultrasonic Transducers and Systems for Imaging and Surgery”
Sponsored by the Department of Biomedical Engineering
Monday, February 2nd, 3:00 Dillman 204

This talk will highlight the development of capacitive micromachined ultrasonic transducer (CMUT) arrays for clinical use that delivers diagnostic information, including anatomy images with a better contrast and resolution, as well as therapeutic and surgical functions not available from conventional piezoelectric tools. Examples of these devices include a tiny panoramic CMUT endoscope integrated with high-intensity focused ultrasound capability for arrhythmia diagnosis and surgery, a needle-shaped CMUT array that is smaller than a human hair for imaging, brain blood-flow-rate measurement, or hearing aids, and a CMUT photoacoustic imager. Using photon-induced acoustic waves for image reconstruction, photoacoustic imaging can capture images of blood and calcification cluster, and is exceptionally useful for identifying diseases/abnormalities related to blood, such as internal bleeding from pre-stroke or early-stage cancer. A novel architecture for photoacoustic imaging has been developed allowing light illumination through an infrared-transparent CMUT array, resulting in a compact portable modality suitable for ambulance and other field use. A broader spectrum on the clinical use of CMUT technology will also be discussed, including the concept of wearable ultrasound patch for soft/hard tissue regeneration or wound healing.

Biomedical Engineering Seminar: Applications of Coursework to Industrial Design and Clinical Practice: Biomedical Engineering/Science Applied to Cardiac Rhythm Disorders

Biomedical Engineering Seminar: Friday, January 30th: EERC 100, 3-4pm
D. Curt Deno, Senior Principle Scientist, St. Jude Medical Tech Center
“Applications of Coursework to Industrial Design and Clinical Practice: Biomedical Engineering/Science Applied to Cardiac Rhythm Disorders”
Sponsored by the Department of Biomedical Engineering

For the last roughly 100 years, technology has played crucial roles in advancing health care. Substantial contributions have come from academic and corporate R&D organizations–environments where learning and research have fostered the innovations that have shaped modern medicine. The speaker’s perspective includes training in both technical and biomedical disciplines. This talk intends to illustrate with examples how a good engineering or science background has repeatedly proven of value in advancing knowledge and developing products that benefit people with heart disease (form pediatric to the elderly). The speaker maintains that even despite occasional project related angst this is one of the most satisfying careers.

Biomedical Engineering seminar: Photoacoustic imaging and focusing in deep biological tissue

The Department of Biomedical Engineering Seminar;
Lidai Wang, Ph.D., Department of Biomedical Engineering, Washington University in St. Louis

Date: Thursday, January 29 – 1:00 pm, Room: 320 Dillman

Title: “Photoacoustic imaging and focusing in deep biological tissue”

Abstract
Taking advantage of rich molecular contrasts and safe non-ionizing radiation, optical imaging has been playing increasingly important roles in biomedical applications. However, a fundamental limit of
optical imaging in biological tissue is light diffusion, which prohibits high-resolution imaging at depths beyond ~1mm. To break through this limit, we recently developed photoacoustic imaging and wavefront shaping technologies for in vivo functional imaging, early cancer detection, and focusing light into diffusive regimes. This presentation will first discuss the development of video-rate functional photoacoustic microscopy which, for the first time, enabled real-time quantitative imaging of oxygen release from single red blood cells in living tissue. Then I will introduce another functional photoacoustic imaging modality, ultrasonic-encoded photoacoustic flowgraphy, which can measure extremely slow blood flow in deep tissue with four times higher sensitivity than ultrasonic Doppler flowmetry. In addition, I will present a novel technique named nonlinear photoacoustic guided wavefront shaping (PAWS) that enables diffraction-limited optical focusing and imaging in highly scattering media such as deep biological tissue.

Biomedical Engineering Seminar: Molecular/Cellular Photoacoustic Imaging and High Sensitivity Non-Contact Optical Detection to Laser

Biomedical Engineering seminar Tuesday January 27, 2015, MEEM 111; 
Jinjun Xia, Ph.D.,
Title: Molecular/Cellular Photoacoustic Imaging and High Sensitivity

Non-Contact Optical Detection to Laser Photoacoustic (PA) imaging is based on the detection of acoustic signals induced by the distribution of specific optical heterogeneities in targeted objects when irradiated by short laser pulses. Contrast in PA images is primarily determined by optical absorption, while spatial resolution is the same as in ultrasound. The advantages of PA imaging including low cost, non-ionizing operation, and sub-mm spatial resolution at centimeters depth, make it a promising modality to probe nanoparticle-targeted abnormalities in real time at cellular and molecular levels. However, detecting rare cell types in a heterogeneous background with strong optical scattering and absorption remains a big challenge. For example, differentiating circulating tumor cells in vivo (typically fewer than 10 cells/mL for an active tumor) among billions of erythrocytes in the blood is nearly impossible. In this presentation, I will present two newly developed techniques, magneto-motive photoacoustic (mmPA) imaging and laser induced nonlinear ultrasonic/photoacoustic imaging, which can significantly increase the sensitivity and specificity of sensing targeted cells or molecular interactions. The primary advantage of these methods is suppression of background signals through magnetic enrichment/manipulation and laser induced bubbles with gold nanospheres coated emulsion beads with simultaneous PA detection of contrast agent targeted objects. The extension of these techniques and their applications in my future research will be presented. In the instrumentation aspect, the current integrated photoacoustic (PA)/Ultrasonic(US) imaging systems use bulky, low repetition rate lasers to provide sufficient pulse energies to image at depth within the body. However, integrating these lasers with real-time clinical ultrasound scanners is problematic due to their size and cost. In this presentation, I will present an integrated PA/US imaging system that can operate at frame rates >30Hz by employing a portable, low-cost, low-pulse energy, high repetition rate, 1053nm laser and a rotating galvo-mirror system enabling rapid laser beam scanning over the imaging area. This approach is demonstrated for potential applications requiring a few centimeters of penetration. The future improvement of this system will also be presented. Non-contact optical detection for laser generated ultrasound is very attractive for its flexibility.

Current non-contact systems have relatively low sensitivity compared to contact piezoelectric detection. They are difficult to adjust, very expensive, and strongly influenced by environmental noise. Here I will present a new type of a balanced fiber-optic Sagnac interferometer as part of an all-optical laser ultrasonics (LU) pump-probe system for non-destructive testing and evaluation of aircraft composites. This new system eliminates the most of current LU drawbacks by combining a new generation of compact, inexpensive fiber lasers with new developments on fiber telecommunication optics and an optimally designed balanced probe scheme. The performance of this LU system is demonstrated on a composite sample with known defects. A system noise figure of 12.3dB above the Nyquist thermal noise limit is achieved at a rough composite surface. Biomedical applications of this system and its modifications will be presented.

Biomedical News Briefs

IMG_5897

The Biotechnology Research Center has announced its Spring 2015 Travel Grant Awards that include the following Biomedical Engineering students. Post-doctoral Research Scientist Presentation:
Qi Xing (Biomed), TERMIS–AM 2014 (poster)
Graduate Student Presentations
Zichen Qian (Biomed), Gordon Research Conference (poster)

Jingfeng Jiang (Biomed/BRC) has received $8,427 from the Radiological Society of North America for a research and development project titled “Development and Validation of Simulations and Phantoms Mimicking the Viscoelastic Properties of Human Liver.”

Technology Century, an online and print publication of the Engineering Society of Detroit, featured editor Matt Roush’s interviews with faculty and graduate students from the College of Engineering at Michigan Tech, the first stop on his annual Tech Tour of university campuses in Michigan.

Tech Times, a technology news website, published an article about Assistant Professor Jingfeng Jiang’s (Biomed) “virtual breast” to improve breast cancer detection.

Jingfeng Jiang, Sean Kirkpatrick and Rupak Rajachar (Biomed/BRC) have received $452,780 from the US Department of Health and Human Services National Institute of Health for a two-year project titled “Virtual Breast Project: Improving Noninvasive Characterization of Tumors.”

Tolou Shokuhfar (ME-EM/Biomed//MuSTI) received $29,600 from the Pacific Northwest National Laboratory for a research and development project titled “In Situ Liquid Microscopy of Biological Materials.”

Science 2.0, a science news website, reported on Assistant Professor Jingfeng Jiang’s (BME) research on a “virtual breast” for improved cancer detection.

Megan Frost (Biomed) has recieved $150,000 from the National Science Foundation for a research and development project titled “Tunable Nitric Oxide Releasing Polymeric Materials.”

Seeing is Believing

image90723-persIf seeing is believing, C.K. Choi (Adjunct Assistant Professor, Biomedical Engineering and Assistant Professor, Mechanical Engineering–Engineering Mechanics) has a passion for clarity—in a very tiny world. The assistant professor of mechanical engineering’s research lies at the micro-scale, in channels no thicker than a strand of hair.
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Biotechnology Research Center Research Forum Awards

Caleb Vogt
Caleb Vogt
The Eleventh Annual Research Forum sponsored by the Biotechnology Research Center was held on Wednesday, Oct. 22, and Thursday, Oct. 23. Forty-one graduate and undergraduate students conducting research in life science, biotechnology, human health and related areas presented posters. Oral presentations were also given. Speakers included Jeremy Goldman (Bio Med), Ashutosh Tiwari (Chem), Hairong Wei (SFRES), Justin Segula (SFRES graduate student), Jingtuo Zhang (Chem graduate student) and Caleb Vogt (Bio Med undergrad student).

Thank you to the participants, the judges and all who helped with another successful BRC Research Forum. A list of BRC award winners is below.

Graduate Grand Prize
Maria Gencoglu (ChE) “A New Virus Purification Process: Virus Flocculation in the Presence of Osmolytes”
Advisor: Caryn Heldt

Graduate Merit Awards
Emily Shearier (Bio Med) “Mesenchymal Stem Cell Spheroids for Therapy Following Axillary Lymph Node Dissection” Advisor: Feng Zhao

Yu Wang (Bio Med) “Building a Virtual Breast Elastography Phantom Lab Using Open Source Software”
Advisor: Jingfeng Jiang

Undergraduate Grand Prize
Caleb Vogt (Bio Med) “Human Mesenchymal Stem Cell Response to Nitric Oxide Relesasing Materials”
Advisors: Megan Frost and Feng Zhao

Undergraduate Merit Award
Mitchell Tahtinen (Bio Med) “Prevascularization of Natural Extracellular Matrix Scaffold”
Advisor: Feng Zhao

Doing Research in a War Zone

Engineers and scientists at Michigan Technological University run into all kinds of roadblocks as they work to move their research from concept to actuality, but exploding rockets aren’t usually one of them.

When Jeremy Goldman took his family to Israel to work on his research on bioabsorbable cardiovascular stents, missiles flying overhead were just one of the facts of war that they had to worry about. Other concerns included terrorists crawling through tunnels, suicide bombers, riots, etc.
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