His talk is entitled “Early competition of actin and vinculin for talin-binding dictates NA’s maturation and force transmission.”
The Chicago Cytoskeleton is a forum for cytoskeletal researchers from the greater Chicago area to meet, hear some great talks, exchange ideas, and socialize.
GRAND RAPIDS, Mich. – Babies with hypoplastic left heart syndrome may soon be able to forego risky surgery due to a device designed by doctors, students, and technicians from West Michigan.
The condition is complex: a portion of the baby’s heart is pumping with only one chamber instead of two.
Dr. Joseph Vettukattil, chief of pediatric cardiology at Spectrum Health, is working with Spectrum Health Innovations and students and staff from Michigan Technological University in Houghton, Mich.
Dr. Brent Mulder, the Senior Director of Spectrum Health Innovations, says the final product could take up to 10 years to complete, but the wait will be worth it.
The undergraduate student team involved in the project include Emma Davis, Kat Farkas, Amanda Gogola, and Ami Kling, Biomedical Engineering. Their advisors were Jeremy Goldman and Smitha Rao, Biomedical Engineering. For Design Expo 2017 at Michigan Tech, they prepared a project “Customizing Transcatheter Nitinol Stents for Treatment of Hypoplastic Left Heart Syndrome in Infants” with abstract:
Hypoplastic left heart syndrome (HLHS) is a congenital heart defect that is mainly characterized by the underdevelopment of the left ventricle. Currently, multiple open heart surgeries are performed to correct this problem. Our team’s goal was to help eliminate the need for the first surgery by designing and testing catheter deployment of a modified nitinol stent with improved patient matching. The idea of deforming the stent with a microsphere to better fit anatomically relevant infant heart geometries was explored, as well as the feasibility of the use of this deformed shape.
The project was sponsored by Spectrum Health Innovations—Helen DeVos Children’s Hospital. It won several awards at the Design Expo:
- Pavlis Honors College Innovation Center for Entrepreneurship Innovation Award: First Place
- Ann Arbor SPARK Design Expo Image Contest: Second Place
- Black & Veatch Building a World of Difference® Student Design Awards: Senior Design Awards (based on poster): Third Place
Keat Ghee Ong (Bio Med/LSTI) is the principal investigator on a project that has received a $20,000 research and development grant from Georgia Tech. The project is titled. “Implementation of a Wireless Sensor System for Monitoring Mechanical Loadings at the Internal Fixation Plates of Rats with Segmental Bone Defects.” This is a one-year project.
By Sponsored Programs.
Ong is an Associate Professor in Biomedical Engineering, the Portage Health Foundation Endowed Professor of Technological Innovations in Health, and an Affiliated Associate Professor in Electrical and Computer Engineering.
Beauty products have come a long way from the days of straight milk and honey, and the technology to test new products is evolving, too.
Volunteers are needed to participate in an industry-supported study aimed at developing laser-based technologies for assessing the effectiveness of skin moisturizers and firming agents. Men and women over the age of 18 are needed, especially individuals over the age of 50.
The one-time measurements take less than an hour. For more information, contact Research Associate Abhinav Madhavachandran (Bio Med).
By Abhinav Madhavachandran.
Bruce Lee (Bio Med) traveled to the 9th International Conference on Materials for Advanced Technologies in Singapore from June 18-23, 2017, to give an invited talk entitled “Stimuli Responsive Biomaterials Utilizing Mussel Adhesive Chemistry”. Additionally, Lee also chaired one session in the “Stimuli Sensitive and Responsive Polymer Biomaterials” symposium in the conference.
Replacement of diseased tissue requires that the implanted material not only have the proper mechanical strength, but it must also have a functioning blood distribution network (vasculature; veins, capillaries), and these are often difficult to manufacture. This project will seek to understand and mimic the structure and vasculature of three-dimensional (3D) cardiac tissue. The goal is to engineer a mechanically strong and functional cell patch for the regeneration of damaged heart tissue.
The proposed research will also provide opportunities for undergraduate and graduate students, as well as underrepresented community college students, to be involved in interdisciplinary stem cell and tissue engineering research. In addition, a series of seminars will be hosted to increase stem cell and tissue engineering awareness among the health community and public in the UP (Upper Peninsula) of Michigan.
The overall objective of the project is to create aligned nanofibrous natural extracellular matrix (ECM) scaffolds for the biofabrication of a prevascularized anisotropic stem cell patch and elucidate the mechanism of microvessel orientation within the in vivo microenvironment. Human mesenchymal stem cells (hMSCs) are immunoregulatory, regenerative, effective in promoting myocardial regeneration, and function as pericytes to stabilize the microvessels formed by endothelial cells (ECs). These unique properties enable hMSCs to combine with ECM scaffolds and ECs to biofabricate an off-the-shelf or patient-specific prevascularized patch, in which hMSCs will play a dual role of stabilizing vasculature formed by ECs in vitro and orchestrating the regeneration of dead cardiac tissue after implantation. In this project, hMSCs will be co-cultured with ECs in a nanofibrous ECM scaffold to form an aligned capillary-like vasculature, and the effects of aligned nanofibers on the density, orientation and maturation of the microvessels will be investigated. The prevascularized hMSC sheets will be multi-layered and further matured in a perfusion bioreactor, and the role of physiological interstitial flow on the inter-connections, alignment and maturation of the existing microvessels within the 3D biomimetic tissue platform will be evaluated. If successful, this project could lead to the development of personalized or off-the-shelf cardiac tissue patches that could dramatically increase the success rate for the treatment of dead cardiac muscle associated with heart attacks.
Design Expo 2017 took place on Thursday, April 13, on campus in the Memorial Union Building Ballroom.
Hosted by the Pavlis Honors College and the College of Engineering, Design Expo highlights hands-on, discovery-based learning at Michigan Tech.
Undergraduates in Biomedical Engineering excelled at this year’s Design Expo.
Black&Veatch Building a World of Difference® Student Design Awards:
Senior Design Awards (based on poster)
1st place: BME – Enhanced Measurement and Analysis of Gait Disturbances – Aspirus
3rd place: BME – Customizing Transcatheter Nitinol Stents for Treatment of Hypoplastic Left Heart Syndrome in Infants – Spectrum Health
Senior Design Honorable Mention
BME – Blubber-Only Implantable Satellite Tracking Device for Humpback Whales
Pavlis Honors College Innovation Center for Entrepreneurship Innovation Award:
1st place: BME – Customizing Transcatheter Nitinol Stents for Treatment of Hypoplastic Left Heart Syndrome in Infants
2nd place: BME – Instrumentation of Manual Medical Devices
3rd place: BME – Posture Correction Device with Haptic Feedback for Parkinson’s Disease
Dr. Xing and Zhao et al. of Michigan Tech University have published a paper entitled: “Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction”
The research group was successful in generating a vascular graft with biomimetic circumferential tensile strength and expression of smooth muscle cell specific genes over static culture.
In previous studies, fibroblast cells were used to create vascular grafts by wrapping a decellularized fibroblast seeded matrix sheet around a temporary mandrel into tubes.
Visit the Research Team’s Website
Keat Ghee Ong (Bio Med/LSTI), is the principal investigator on a project that has received a $467,660 research and development grant from the US Department of Health and Human Services, National Institutes of Health.
The project is titled “Mechanically Active Magnetoelastic System for Controlled Loading Environment to Promote Vascularized Bone Regeneration.” This is a three-year project.
By Sponsored Programs.
Lee chaired a session entitled “Bioadhesive Chemistry” and was elected vice chair of the Bioadhesion Division within the Adhesion Society. Lee will serve as the chair of the division in the 42nd Annual Meeting of the Adhesion Society in 2019.
Liu gave an oral presentation entitled “Moldable Nanocomposite PEG Hydrogel Formed by Mussel-Inspired Chemistry as Fit-to-Shape Sealant.”
He gave an oral presentation entitled “Development of a Novel Fibrin-polydopamine Adhesive Hydrogel for Marine Tracking and Wound Healing Applications,” a project directed by Rupak Rajachar (Bio Med).