Category Archives: News

Bruce P. Lee Publishes on a Model Polymer System

Bruce P Lee Catechol Graphic

Hao Meng, Yuan Liu and Bruce P. Lee have co-authored “Model Polymer System for Investigating the Generation of Hydrogen Peroxide and its Biological Responses during the Crosslinking of Mussel Adhesive Moiety” in Acta Biomaterialia.

To harvest the unique underwater adhesive properties of mussel adhesive proteins, scientists have designed various synthetic mimics of these proteins to create novel biomedical adhesives, drug carriers, and tissue engineering scaffolds.

The team designed a model system to systemically characterize the biocompatibility and biological responses associated with the byproduct (i.e., hydrogen peroxide) generated during the curing process of biomimetic adhesive moieties.

Hydrogen peroxide is an important biological molecule with multiple biological functions (i.e., wound healing, disinfectant, etc.). This is the first report to characterize the release of hydrogen peroxide during the curing process of the mussel adhesive moieties; however, the biocompatibility of these biomimetic materials have not been fully characterized.

http://dx.doi.org/10.1016/j.actbio.2016.10.016

Bruce P. Lee Publishes on Mussel Adhesive Protein

Mussel Adhesive Applications

Bruce P. Lee and Pegah Kord Forooshani published “Recent Approaches in Designing Bioadhesive Materials Inspired by Mussel Adhesive Protein” in the Journal of Polymer Science Part A: Polymer Chemistry.

Mussels can bind to various wet surfaces, such as a ship hull or rock, through the secretion of adhesive proteins.

This paper reviews the remarkable underwater adhesion of these proteins, which have inspired many scientists to incorporate such unique chemistries into the design of a wide range of materials. The chemistry extents to biomaterials, such as adhesives, coatings, and therapeutic drug carriers, as well as to smart materials, like smart adhesives, actuators, and self-healing materials.

This is an invited and peer-reviewed review article which provides a comprehensive and updated information on how the adhesive proteins function and methods for using these designs to create new and improved functional materials.

DOI: 10.1002/pola.28368

Bruce Lee Team Publishes in Chemistry of Materials

Bruce Lee (Bio Med) and graduate student Ameya Narkar (Bio Med) coauthored the paper “pH Responsive and Oxidation Resistant Wet Adhesive based on Reversible Catechol-Boronate Complexation.” The paper was published in Chemistry of Materials. This paper was also coauthored by Tech alumni Brett Barker and Matthew Clisch, as well as Jingfeng Jiang (Bio Med).

DOI: 10.1021/acs.chemmater.6b01851

From Tech Today.

Rapid Design of 3D Printed Casts

Subject Specific Wrist CastMaterialise, a corporate blog, published an article about 3-D printed orthopaedic casts designed by a team from Michigan Tech to conform to the individual needs of each patient’s fracture.

From Tech Today.

Could 3D Printing Provide an Alternative to Plaster Casts?

Anyone who has ever had a broken arm, sprained ankle or anything that requires wearing a cast undoubtedly remembers how uncomfortable it was. Sure, it was fun to get everyone’s signature on your arm or leg, but that didn’t make up for the itchiness, the rash and the difficulties involved when taking a shower. A bright team of engineers at Michigan Technological University thought there had to be a better solution, and came up with a lightweight, porous, 3D-printed alternative instead.

Dr. Jingfeng Jiang, leader of the project, commented: “The Lightweight Structures Module enabled us to rapidly design and create prototypes of these orthopaedic casts given any patient-specific wrist geometry. Furthermore, the software allowed us to export the virtual design directly to ANSYS for FEA analysis, so that we could make sure the model was strong enough to withstand different loading conditions.”

Read more at Materialise, by Stephanie Benoit.

Goldman Presents at From Lab to Marketplace

How do discoveries in university labs turn into commercially available—and potentially lifesaving—products?

This Wednesday, May 25, 2016, teams of Michigan Tech scientists and engineers will present their innovative technologies to a state funding review committee. The reviewers, officially designated an Oversight Committee, will be making decisions on grants from the Michigan Translational Research and Commercialization (MTRAC) program, a $6 million state-funded program developed and managed by the Michigan Economic Development Corporation (MEDC) to help commercialize university translational research.

An example of a team that will present on Wednesday afternoon is Professor Jarek Drelich (MSE) and Associate Professor Jeremy Goldman (BME). They are working on developing a metal alloy that would perform well as a biodegradable stent for heart surgery and other uses where a biodegradable material is desirable. They have been working for some time to find a material with all the necessary properties that will biodegrade harmlessly in the body over a set period of time.

Read more at Tech Today, by Jenn Donovan.

Biomedical Engineers Inducted into Order of the Engineering

On April 18, 2016, the Department of Chemical Engineering hosted its Order of the Engineer induction ceremony.

The ceremony welcomed 53 new members to the order, including two biomedical engineers and three faculty and staff members.

In 2015, 27 members were inducted, bringing the total of the Michigan Tech Chemical Engineering cohort to 134 since 2014.

Read more at Tech Today, by Chemical Engineering.

Life Science and Technology Institute (LSTI) Research Forum

IMG_3557aLSTI first Annual Research Forum
by Department of Biomedical Engineering

The Michigan Tech community viewed the first Annual Life Science and Technology Institute (LSTI) Research Forum that was held Friday September 25. Posters were in the Memorial Union Ballroom A1. Student awards were presented. Undergraduate and graduate students working in life science-related fields showed their research posters in separate competitions.

Sanaz Habibi (Adrienne Minerick’s M.D.-ERL Lab), PhD student in the Chemical Engineering department, won the grand prize for the best poster for her work on “Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?.”

Sanaz Habibi : Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?
Sanaz Habibi : Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?

Graduate Merit Awards winners for the Life Science and Technology Institute (LSTI) Research Forum indlude: Graduate students:

Ramkumar Mohan (Biology)—”MicroRNA-483, A Differentially Expressed MicroRNA Between Pancreatic Beta Cells and Alpha Cells,” Advisor: Zhang/Tang
Ni Fan (Chem)—”Glycan-Dependent Mutual and Reversible Sequestration,” Advisor: Dam
Robert Larson (KIP)—”High Salt Intake Augments Excitability of Pre-sympathetic PVN Neurons,” Advisor: Chen

The Undergraduate Student award winners included: Grand Prize: Jared Pecore (Biology)—”The Mechanisms Underlying α-Amanitin Resistance in Drosophila melanogaster: A Microarray Analysis,” Advisor: Werner
Undergraduate Merit Award: Dakota Anderson (KIP)—”Upper-Extremity Eccentric Exercise: Increases in Muscle Strength and Power at Moderate Training Intensities”

Jared Pecore- Grand Prize, Undergrad
Jared Pecore- Grand Prize, Undergrad


View Photo gallery of Life Science and Technology Institute (LSTI) Research Forum

Biomedical News Briefs

IMG_5897

Jeremy Goldman (BE/IMP) is the principal investigator on a research and development project that received a $442,004 grant from the U.S. Department of Health and Human Services, National Institutes of Health. The two-year project is titled, Biodegradation Mechanism and Rate, Biocompatibility, and Toxicity for Novel Zn-Mg Stent Materials. Also working on the project are Jaroslaw Drelich (MSE) and Feng Zhao (BE).

Rupak Rajachar (Bio Med) is the primary investigator of a project that is the recipient of a $326,346 research and development grant from the U.S. Department of Health and Human Services – National Institutes of Health.
The project is Adhesive PEG-Fibrinogen Nitric Oxide Releasing Hydrogetls for use as a Wound Healing and Tissue Engineering Support. Also working the project is Bruce Lee (Bio Med, and Megan Frost (Bio Med).

Lake Superior Magazine’s June-July issue includes an article on several Michigan Tech biomedical researchers including Assistant Professor Feng Zhao, Associate Professor Mo Rastgaar, Professor Adrienne Minerick and several biomedical engineering students.

The Michigan Tech Vice President for Research Office announces the Research Execellence Fund Awards. Thanks to the volunteer review committees, as well as the deans and department chairs, for their time spent on this important internal research award process. Infrastructure Enhancement Grants: Sean Kirkpatrick, BRC/Biomed Eng. Repair and Upgrade Advanced Fluorescent Microscope; Research Seed Grants: Feng Zhao, Biomed Eng and Jingfeng Jiang, BRC/Biomed Eng; Link to full list

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