Category Archives: Research

Funding for Keat Ghee Ong on Wireless Sensing of Bone Defects

Keat Ghee Ong
Keat Ghee Ong

Keat Ghee Ong (Bio Med/LSTI) is the principal investigator on a project that has received a $20,000 research and development grant from Georgia Tech. The project is titled. “Implementation of a Wireless Sensor System for Monitoring Mechanical Loadings at the Internal Fixation Plates of Rats with Segmental Bone Defects.” This is a one-year project.

By Sponsored Programs.

Ong is an Associate Professor in Biomedical Engineering, the Portage Health Foundation Endowed Professor of Technological Innovations in Health, and an Affiliated Associate Professor in Electrical and Computer Engineering.


Volunteers Needed For Study

Beauty products have come a long way from the days of straight milk and honey, and the technology to test new products is evolving, too.

Volunteers are needed to participate in an industry-supported study aimed at developing laser-based technologies for assessing the effectiveness of skin moisturizers and firming agents. Men and women over the age of 18 are needed, especially individuals over the age of 50.

The one-time measurements take less than an hour. For more information, contact Research Associate Abhinav Madhavachandran (Bio Med).

By Abhinav Madhavachandran.



STEM Cell Research Funding for Feng Zhao

Feng Zhao
Feng Zhao

Feng Zhao (Bio Med/LSTI) is the principal investigator on a project that has received a $310,000 research and development grant from the National Science Foundation. This is a three-year project.

Anisotropic Human Mesenchymal Stem Cell Patch with Oriented Vasculature

ABSTRACT

Replacement of diseased tissue requires that the implanted material not only have the proper mechanical strength, but it must also have a functioning blood distribution network (vasculature; veins, capillaries), and these are often difficult to manufacture. This project will seek to understand and mimic the structure and vasculature of three-dimensional (3D) cardiac tissue. The goal is to engineer a mechanically strong and functional cell patch for the regeneration of damaged heart tissue.

The proposed research will also provide opportunities for undergraduate and graduate students, as well as underrepresented community college students, to be involved in interdisciplinary stem cell and tissue engineering research. In addition, a series of seminars will be hosted to increase stem cell and tissue engineering awareness among the health community and public in the UP (Upper Peninsula) of Michigan.

The overall objective of the project is to create aligned nanofibrous natural extracellular matrix (ECM) scaffolds for the biofabrication of a prevascularized anisotropic stem cell patch and elucidate the mechanism of microvessel orientation within the in vivo microenvironment. Human mesenchymal stem cells (hMSCs) are immunoregulatory, regenerative, effective in promoting myocardial regeneration, and function as pericytes to stabilize the microvessels formed by endothelial cells (ECs). These unique properties enable hMSCs to combine with ECM scaffolds and ECs to biofabricate an off-the-shelf or patient-specific prevascularized patch, in which hMSCs will play a dual role of stabilizing vasculature formed by ECs in vitro and orchestrating the regeneration of dead cardiac tissue after implantation. In this project, hMSCs will be co-cultured with ECs in a nanofibrous ECM scaffold to form an aligned capillary-like vasculature, and the effects of aligned nanofibers on the density, orientation and maturation of the microvessels will be investigated. The prevascularized hMSC sheets will be multi-layered and further matured in a perfusion bioreactor, and the role of physiological interstitial flow on the inter-connections, alignment and maturation of the existing microvessels within the 3D biomimetic tissue platform will be evaluated. If successful, this project could lead to the development of personalized or off-the-shelf cardiac tissue patches that could dramatically increase the success rate for the treatment of dead cardiac muscle associated with heart attacks.


Vascular Graft Tissue Research Featured in Synthecon

ECM Fibril BundlesDr. Xing and Zhao et al. of Michigan Tech University have published a paper entitled: “Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction”

The research group was successful in generating a vascular graft with biomimetic circumferential tensile strength and expression of smooth muscle cell specific genes over static culture.

In previous studies, fibroblast cells were used to create vascular grafts by wrapping a decellularized fibroblast seeded matrix sheet around a temporary mandrel into tubes.

Visit the Research Team’s Website

Read more in the article “VASCULAR GRAFT TISSUE ENGINEERING IN THE RCCS” in Synthecon.


Keat Ghee Ong Receives Funding for Bone Regeneration Research

Keat Ghee Ong
Keat Ghee Ong

Keat Ghee Ong (Bio Med/LSTI), is the principal investigator on a project that has received a $467,660 research and development grant from the US Department of Health and Human Services, National Institutes of Health.

The project is titled “Mechanically Active Magnetoelastic System for Controlled Loading Environment to Promote Vascularized Bone Regeneration.” This is a three-year project.

By Sponsored Programs.


Researchers Attend 40th Annual Meeting of the Adhesion Society

Annual Meeting Adhesion Society

Bruce Lee (Bio Med), Yuan Liu and Weilue He attended the 40th Annual Meeting of the Adhesion Society Feb. 26 through March 1, 2017, in St. Petersburg, Florida.

Lee chaired a session entitled “Bioadhesive Chemistry” and was elected vice chair of the Bioadhesion Division within the Adhesion Society. Lee will serve as the chair of the division in the 42nd Annual Meeting of the Adhesion Society in 2019.

Liu gave an oral presentation entitled “Moldable Nanocomposite PEG Hydrogel Formed by Mussel-Inspired Chemistry as Fit-to-Shape Sealant.”

He gave an oral presentation entitled “Development of a Novel Fibrin-polydopamine Adhesive Hydrogel for Marine Tracking and Wound Healing Applications,” a project directed by Rupak Rajachar (Bio Med).



Bruce P. Lee Publishes on a Model Polymer System

Bruce P Lee Catechol Graphic

Hao Meng, Yuan Liu and Bruce P. Lee have co-authored “Model Polymer System for Investigating the Generation of Hydrogen Peroxide and its Biological Responses during the Crosslinking of Mussel Adhesive Moiety” in Acta Biomaterialia.

To harvest the unique underwater adhesive properties of mussel adhesive proteins, scientists have designed various synthetic mimics of these proteins to create novel biomedical adhesives, drug carriers, and tissue engineering scaffolds.

The team designed a model system to systemically characterize the biocompatibility and biological responses associated with the byproduct (i.e., hydrogen peroxide) generated during the curing process of biomimetic adhesive moieties.

Hydrogen peroxide is an important biological molecule with multiple biological functions (i.e., wound healing, disinfectant, etc.). This is the first report to characterize the release of hydrogen peroxide during the curing process of the mussel adhesive moieties; however, the biocompatibility of these biomimetic materials have not been fully characterized.

http://dx.doi.org/10.1016/j.actbio.2016.10.016


Bruce P. Lee Publishes on Mussel Adhesive Protein

Mussel Adhesive Applications

Bruce P. Lee and Pegah Kord Forooshani published “Recent Approaches in Designing Bioadhesive Materials Inspired by Mussel Adhesive Protein” in the Journal of Polymer Science Part A: Polymer Chemistry.

Mussels can bind to various wet surfaces, such as a ship hull or rock, through the secretion of adhesive proteins.

This paper reviews the remarkable underwater adhesion of these proteins, which have inspired many scientists to incorporate such unique chemistries into the design of a wide range of materials. The chemistry extents to biomaterials, such as adhesives, coatings, and therapeutic drug carriers, as well as to smart materials, like smart adhesives, actuators, and self-healing materials.

This is an invited and peer-reviewed review article which provides a comprehensive and updated information on how the adhesive proteins function and methods for using these designs to create new and improved functional materials.

DOI: 10.1002/pola.28368