Category Archives: Michigan Tech News

New Funding – Xiaohu Xia wins CAREER Award

image113518-persThere is something very noble about Xiaohu Xia’s research. He wants to use palladium, platinum, ruthenium and other corrosion-resistant metals to refine tests to detect biomarkers for cancer and infectious diseases. To do so, he plans to use nanostructures made of these noble metals that mimic natural enzymes and has earned a CAREER Award from the National Science Foundation (NSF) to focus on this research.

The grant covers five years, totaling $457,783, and enables Xia to dig deep into the structure-property relationships of the bimetallic peroxidase mimics at the atomic level. Even small changes in nanostructures can produce big results, demonstrated by his lab with improvements in the catalytic efficiencies of iridium-coated palladium and ruthenium nanostructures.

Read the full story on the Michigan Tech news website.



New Glycobiology Study led by Tarun Dam

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Tarun Dam led a new study, published this week in Biochemistryexamining the biomechanics of galectin-3’s interaction with glycosaminoglycans (GAG) and proteoglycans. His team includes graduate students Melanie Talaga, Ni Fan, Ashli Fueri, Robert Brown and Research Assistant Professor Purnima Bandyopadhyay.

At the Laboratory of Mechanistic Glycobiology, Dam and his students study the sugar, including glucose and other structural, complex sugars, that fuel our bodies. GAGs assist in controlling growth factor proteins, which go unchecked as cancerous tumors grow.

Even though the findings of the study were unexpected, it opens up new possibilities for understanding glycobiology and biomechanics. “Seeing galectin-3 interact with GAGs and proteoglycans is like finding a rose in the petunias—it’s very unexpected,” Dam says. “It’s fair to say that this requires revisiting the reported biological functions of GAGs, proteoglycans and galectin-3.”

Next, Dam and his team look into additional research, “Now we have to reconsider the whole drama, retracing the steps and actions of that character… we are using cell lines and animal models to study this interaction in a cellular context.”

Read more on Michigan Tech News, by Allison Mills.

 


Chemistry in Michigan Tech News

Galectin-3 Proteins in Biochemistry Earns National Coverage
August 15, 2016
Sticking It To Rogue DNA
August 11, 2016
Tech Student Wins Goldwater Scholarship
April 8, 2016
A Noble Calling: Ruthenium Nanoframes Open the Doors to Better Catalysts
March 31, 2016
The Case of the Sticky Protein: Interdisciplinary Team Puts Together Clues To Better Sense Surface Hydrophobicity
December 18, 2015
Thyroid Cancer Biomarker Assays May Show Inaccurate Readings
November 12, 2015
Lynn Mazzoleni Leads a Team to Bring a New High-Resolution Spectrometer to Campus
October 23, 2015
Detecting lysosomal pH with fluorescent probes
April 8, 2015
Chemistry Professor Gives Women in STEM a Step Up
January 14, 2015
Michigan Tech Deploys Under-ice Research Instruments in Frozen Portage Waterway
January 12, 2015
Carnegie Museum: Lake Superior Discussion
November 13, 2014
Breakthrough Understanding of Biomolecules Could Lead to New and Better Drugs
August 22, 2014
Fang, Pokharel Receive Rath Award for Breakthrough Method of Purifying Biomolecules
April 28, 2014
Reaching for the Future at Society of Women Engineers Conference
February 25, 2014