Tag: Chemistry

I started my doctoral research in Spring 2018 with Dr. Christo Z. Christov in the Department of Chemistry at Michigan Technological University. Before that, I completed my B. Tech. in Chemical Engineering from Rashtrasant Tukadoji Maharaj Nagpur University was working as Project Research Assistant at the Indian Institute of Technology Bombay. My research focuses on utilizing computational techniques like Molecular Dynamics (MD), Quantum Mechanics (QM), and Quantum Mechanics/ Molecular Mechanics (QM/MM) to explore structure-function relationships in enzyme catalysis. 

During my time as a PhD candidate at Michigan Tech, I have researched an NSF funded project about ethylene forming enzyme. In this project, my research involved developing an enzyme model to establish the chemical mechanism of ethylene formation and L-Arg hydroxylation. I further explored if external electric fields can switch between the two reactivities of ethylene forming enzyme, with an aim to optimize ethylene generation. I have also worked on an NIH funded project about histone demethylases, activities of which have been linked to various forms of cancers. I used molecular dynamics simulations and combined QM/MM approach to establish the enzyme catalytic mechanism and structure-function relationship. Moreover, I have developed a computational framework for identifying second coordination sphere and long-range residues relevant for catalysis through analysis of protein correlated motions. 

I am grateful to the Graduate Dean Awards Advisory Panel and the Dean for awarding me the Doctoral Finishing Fellowship. I would also like to offer my special thanks to my advisor Dr. Christo Z. Christov, for his support throughout my PhD program.

In the spring of 2017, I started my journey at MTU as a Ph.D. student in Chemistry. The focus of my Ph.D. research is on the design and development of carbon dots (CDs) which are fluorescent nanomaterials with great potential in sensing and bioimaging. During my Ph.D., I could successfully synthesize high quantum yield CDs for iron ions sensing with the potential to be used in the clinical diagnosis of iron-related diseases or environmental monitoring of water quality. Also, I investigated the design of near-infrared nitrogen-doped CDs that would be ideal for bioimaging applications.

It is a great honor to receive the Doctoral Finishing Fellowship, and I am grateful to the graduate school and the Graduate Dean Awards Advisory Panel for their support. Through this fellowship, I will be able to focus on writing my dissertation and publishing my work in journals. Additionally, I would like to take this opportunity to thank my advisor, Dr. Patricia Heiden, for her help and support throughout my Ph.D. journey.

I completed my bachelor’s in science (2012) and master’s in science (2014) both in Microbiology from India.  I worked as an intern in the Department of Molecular Biology, Bhabha Atomic Research Center, one of India’s premier nuclear research institutes. There my interest in research grew stronger, and I decided to pursue doctoral research. I moved to the US in 2015 to obtain a second master’s degree in Forest Molecular Genetics and Biotechnology. I joined the Department of Chemistry in 2017 to begin my Doctoral studies in the Laboratory of Mechanistic Glycobiology under the guidance of Dr. Tarun Dam. My doctoral research focuses on a novel protein purification technique that we developed in our lab. My other research project is based on the structure-function relationship of a mutated cancer-related protein Galectin-3. Wet-bench research, scientific journal publications and presenting my work at several conferences groomed me to become a better scientist and expanded my knowledge in the field of Protein Biochemistry and Glycobiology.

I would like to extend my sincere thanks to my advisor for his guidance and having faith in me and am also thankful to the Department of Chemistry for giving me this opportunity to conduct my doctoral research. I am grateful to the Graduate School for awarding me a Finishing Fellowship, which will be immensely helpful to finish up my doctoral studies.

Born and raised in the Upper Peninsula, I started my journey in Manistique, MI and since then have slowly migrated an hour and a half northwest every handful of years. The first time was after high school where I then attended undergraduate studies at NMU and discovered I enjoyed research under some wonderful professors. The second time was to come here to MTU and conduct my doctoral research under Dr. Tarun Dam in the Lab of Mechanistic Glycobiology. We perform biochemical studies on therapeutically promising plant biomolecules as well as human proteins associated with diseases. We carry out fundamental investigations into the behavior of molecules in living systems. This has led me to learn a multitude of incredible techniques and instrumentation skills, foremost being electron microscopy here on campus which is now a passion of mine. I believe we do fascinating work while striving to always put our best foot forward. I would like to thank Michigan Tech and our graduate school for awarding me with the Finishing Fellowship, it is a great assistance to myself and our lab.