Monday, March 22, 2010 3:00 – 4:00 pm
Room G06, Rekhi Hall
Ian O. Smith
Postdoctoral Research Fellow
University of Michigan School of Dentistry
Biomimetics is a useful approach for Tissue Engineering applications, in which wemimic the naturally occurring ECM to positively affect biologic response and tissue formation using scaffolds, which promote cell differentiation, provide biologicalcues, allow nutrient transfer and provide sufficient mechanical properties. Onearea of interest is bone tissue engineering, where ECM collagen is mimicked byfabrication of polymer nanofibers, which are subsequently mineralized through abiomimetic process. The techniques that are currently available to create such ascaffold system have shown promise, but have inherent limitations. My researchaims to combine these existing techniques with what we can learn though ourunderstanding of the surface sciencerelated interactions which occur during earlystage mineralization in order to build upon the processes currently used tofabricate these scaffolds to develop new techniques. We can then expand thecurrent limits and build a scaffold that promotes more effective biologic responseand tissue formation.