Imaging Sub-pixel Motion using Optical Coherence Tomography

Friday, September 16 at 3:00—U113 M&M Building

Niloy Choudhury, PhD, Department of Biomedical

It is important to measure sub-pixel motion in biological specimen as it allows us to investigate wide range of biological phenomenon ranging from micro-mechanical motion in tissue to estimating metabolic activity. Optical Coherence Tomography is one such technique that can provide images of sub-pixel motion with cellular level resolution (~10 μm). A Time Domain Optical Coherence Tomography (TD-OCT) based system has been developed to investigate “hearing mechanism” by measuring sub nanometer motion of the organ of Corti in a guinea pig. A 3-D optical micro-angiography system based on the principles of Fourier Domain Optical Coherence Tomography (FD-OCT) has also been developed. Combining the FD-OCT system with a novel imaging process allows us to achieve full depth of scan for structural and blood flow measurements. Using this novel device Micro-circulation in a gerbil cochlea is investigated as it is believed that a change in blood flow influences a number of cochlear diseases that can lead to


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