Author: ehgroth

Biomedical Engineering Graduate Seminar: Design and Analysis of Next Generation Sequencing Data

image125972-persBiomedical Engineering Graduate Seminar: Friday, October 30-3:00 pm, U113 M&M
The Department of Biomedical Engineering presents: Dr. Kui Zhang, Professor, Mathematical Sciences, Michigan Technological University

Title: Design and Analysis of Next Generation Sequencing Data

In this talk, I will present my recent research on design and analysis of next generation sequencing (NGS) data. The talk can be divided into two parts. The first part of the talk will focus on developments of novel statistical methods. The Hidden Markov Model in genotype calling from NGS data will be intro-duced. Its extension that can use additional information from sequencing reads for improvements will be described. The further extensions that can use family samples and admixed sample will be discussed. The second part of the talk will mainly be on several collaborative projects including the identification of genetic variants that are associated with HIV infection in a genetic association study, a study with the RNA sequencing technologies, etc. The problems and the statistical methods used in these analysis will be discussed.

Graduate Seminar Kui Zhang

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Life Science and Technology Institute (LSTI) Research Forum

IMG_3557aLSTI first Annual Research Forum
by Department of Biomedical Engineering

The Michigan Tech community viewed the first Annual Life Science and Technology Institute (LSTI) Research Forum that was held Friday September 25. Posters were in the Memorial Union Ballroom A1. Student awards were presented. Undergraduate and graduate students working in life science-related fields showed their research posters in separate competitions.

Sanaz Habibi (Adrienne Minerick’s M.D.-ERL Lab), PhD student in the Chemical Engineering department, won the grand prize for the best poster for her work on “Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?.”

Sanaz Habibi : Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?
Sanaz Habibi : Do Faradaic Reactions Cause Hemolysis in Non-Uniform Alternating Current Electric Fields?

Graduate Merit Awards winners for the Life Science and Technology Institute (LSTI) Research Forum indlude: Graduate students:

Ramkumar Mohan (Biology)—”MicroRNA-483, A Differentially Expressed MicroRNA Between Pancreatic Beta Cells and Alpha Cells,” Advisor: Zhang/Tang
Ni Fan (Chem)—”Glycan-Dependent Mutual and Reversible Sequestration,” Advisor: Dam
Robert Larson (KIP)—”High Salt Intake Augments Excitability of Pre-sympathetic PVN Neurons,” Advisor: Chen

The Undergraduate Student award winners included: Grand Prize: Jared Pecore (Biology)—”The Mechanisms Underlying α-Amanitin Resistance in Drosophila melanogaster: A Microarray Analysis,” Advisor: Werner
Undergraduate Merit Award: Dakota Anderson (KIP)—”Upper-Extremity Eccentric Exercise: Increases in Muscle Strength and Power at Moderate Training Intensities”

Jared Pecore- Grand Prize, Undergrad
Jared Pecore- Grand Prize, Undergrad

View Photo gallery of Life Science and Technology Institute (LSTI) Research Forum

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Biomedical News Briefs


Jeremy Goldman (BE/IMP) is the principal investigator on a research and development project that received a $442,004 grant from the U.S. Department of Health and Human Services, National Institutes of Health. The two-year project is titled, Biodegradation Mechanism and Rate, Biocompatibility, and Toxicity for Novel Zn-Mg Stent Materials. Also working on the project are Jaroslaw Drelich (MSE) and Feng Zhao (BE).

Rupak Rajachar (Bio Med) is the primary investigator of a project that is the recipient of a $326,346 research and development grant from the U.S. Department of Health and Human Services – National Institutes of Health.
The project is Adhesive PEG-Fibrinogen Nitric Oxide Releasing Hydrogetls for use as a Wound Healing and Tissue Engineering Support. Also working the project is Bruce Lee (Bio Med, and Megan Frost (Bio Med).

Lake Superior Magazine’s June-July issue includes an article on several Michigan Tech biomedical researchers including Assistant Professor Feng Zhao, Associate Professor Mo Rastgaar, Professor Adrienne Minerick and several biomedical engineering students.

The Michigan Tech Vice President for Research Office announces the Research Execellence Fund Awards. Thanks to the volunteer review committees, as well as the deans and department chairs, for their time spent on this important internal research award process. Infrastructure Enhancement Grants: Sean Kirkpatrick, BRC/Biomed Eng. Repair and Upgrade Advanced Fluorescent Microscope; Research Seed Grants: Feng Zhao, Biomed Eng and Jingfeng Jiang, BRC/Biomed Eng; Link to full list

Assistant professor Bruce Lee (Bio Med) was invited to give an oral presentation at the Adhesive & Sealant Council (ASC) 2015 Spring Convention & EXPO, Monday through Wednesday in Nashville. ASC is a North American trade association comprised of more than 130 U.S. companies in the adhesive and sealant industry.

Jaroslaw Drelich (MSE) and Jeremy Goldman (Bio Med) have received $203,996 from the US Department of Health and Human Services, National Institute of Health for the first year of a 22 month-long project titled “Improved Biocompatibility and Biodegradation of Zn-based Stent Materials through Surface Non-Engineering.”

The Biotechnology Research Center has announced its Spring 2015 Travel Grant Awards that include the following Biomedical Engineering students. Post-doctoral Research Scientist Presentation:
Qi Xing (Biomed), TERMIS–AM 2014 (poster)
Graduate Student Presentations
Zichen Qian (Biomed), Gordon Research Conference (poster)

Jingfeng Jiang (Biomed/BRC) has received $8,427 from the Radiological Society of North America for a research and development project titled “Development and Validation of Simulations and Phantoms Mimicking the Viscoelastic Properties of Human Liver.”

Technology Century, an online and print publication of the Engineering Society of Detroit, featured editor Matt Roush’s interviews with faculty and graduate students from the College of Engineering at Michigan Tech, the first stop on his annual Tech Tour of university campuses in Michigan.

Tech Times, a technology news website, published an article about Assistant Professor Jingfeng Jiang’s (Biomed) “virtual breast” to improve breast cancer detection.

Jingfeng Jiang, Sean Kirkpatrick and Rupak Rajachar (Biomed/BRC) have received $452,780 from the US Department of Health and Human Services National Institute of Health for a two-year project titled “Virtual Breast Project: Improving Noninvasive Characterization of Tumors.”

Tolou Shokuhfar (ME-EM/Biomed//MuSTI) received $29,600 from the Pacific Northwest National Laboratory for a research and development project titled “In Situ Liquid Microscopy of Biological Materials.”

Science 2.0, a science news website, reported on Assistant Professor Jingfeng Jiang’s (BME) research on a “virtual breast” for improved cancer detection.

Megan Frost (Biomed) has recieved $150,000 from the National Science Foundation for a research and development project titled “Tunable Nitric Oxide Releasing Polymeric Materials.”

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Superior Ideas: Biomedical Engineering

IMG_5897Biomedical Engineering Researchers Feng Zhao and Bruce Lee have separate Superior Ideas projects called “Making heart Bypass Grafts Safer” and “Soft Robotic Component with a Mussel Tone” respectively.

Superior Ideas helps bring university research and public service projects to life. Through Superior Ideas, researchers can spread the word of their projects—and gain funding along the way.

Superior Ideas operates using crowdfunding, a relatively new concept in which individuals join together through many small donations to help fund a large project. When donors give to a researcher’s project, they are helping fund technological advances, and showing their financial support and interest in the project’s goals. There is no shortage of sites taking advantage of this new venue for funding. However, Superior Ideas offers donors, researchers, and partner Universities two distinct advantages over other crowdfunding sites:

  • Superior Ideas is operated by Michigan Technological University, a public nonprofit university, enabling donors from the United States to claim a charitable donation for federal income tax purposes.
  • Superior Ideas verifies the validity of each project posted on our website; since we are run in conjunction with a leading research university, we can ensure that only the best-of-the-best projects are being offered to potential donors.
  • Superior Ideas exists to empower both researchers and donors by providing a platform for university researchers to describe their innovative and ambitious projects to the public, and donors can express their interest and support with just the click of a mouse to the project links listed below.

ZhaoZhao’s project:
Decription: “This research aims to provide solutions for problems associated with the regeneration of small-diameter vessels to be used in cardiovascular procedures. Supporting this project will move the crucial technology toward clinical trials, commercialization, and saving lives.”


Timeline: This project will expire on Sunday, September 6th.

LeeLee’s project:
Description: “By incorporating chemistry commonly utilized by marine mussels, this research plans to create soft robotic components which could better interface with biological systems.”


Timeline: This project will expire on Sunday, August 30th.

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BME Students Win Awards in Design Expo

The International Business Ventures took first place in the Enterprise program and the

First Place Award Enterprise IBV (International Business Ventures)
Team Leaders: Leslie LaLonde and Andrew Clark, Biomedical Engineering
Advisors: Robert Warrington, Pavlis Honors College
Sponsor: Pavlis Honors College

Project Overview: The Infant Heart Annunciator is a small, BandAid-shaped device that detects an infant’s electrocardiogram, producing a visible flash and audible tone. Often in developing countries, those present at birth do not have the training or equipment needed to determine if an unresponsive infant is alive. Our goal is to eliminate this unnecessary loss of life. Our team is also designing a simple, yet reliable, ventilator that can be stockpiled by hospitals. Typically, hospitals maintain sufficient numbers of ventilators; however, an increase of patients resulting from a pandemic could create a shortage of ventilators. The current high cost of most ICU ventilators prevents hospitals from stockpiling these machines.

Part of the First Place team  that won the Enterprise Award  IBV (International Business Ventures)
Part of the First Place team that won the Enterprise Award IBV (International Business Ventures)

BME Team won Honorable Mention – Compliance Keweenaw: Aspirus Keweenaw Hand-washing Compliance System
Team Members: Anna Waller, Jannah Brandt, Drew Markel, Creighton Bradley, and Rebecca Manshaem, Biomedical Engineering
Advisor: Bruce Lee, Biomedical Engineering
Sponsor: Aspirus Keweenaw

Project Overview: Hand hygiene is of importance to hospitals not only for the safety and health of employees but also to reduce the spread of hospital-acquired infections and protect patients. Aspirus Keweenaw recruited our team to create an automated system to track hand-washing compliance among employees to assist them in their goal of 100 percent compliance. We created a system using a microcontroller and RFID readers to detect when a healthcare worker enters a patient’s room and reaches compliance using the sanitizing foam dispenser. This system will be placed near the doorway and communicate with a wristband that identifies the healthcare worker and vibrates as a reminder if compliance is not reached.

 BME Team won Honorable Mention  – Compliance Keweenaw: Aspirus Keweenaw Hand-washing Compliance SystemTeam Members: Anna Waller, Jannah Brandt, Drew Markel, Creighton Bradley, and Rebecca Manshaem, Biomedical Engineering
BME Team won Honorable Mention – Compliance Keweenaw: Aspirus Keweenaw Hand-washing Compliance System
Team Members: Anna Waller, Jannah Brandt, Drew Markel, Creighton Bradley, and Rebecca Manshaem, Biomedical Engineering

BME Teams were featured in the Michigan Tech news article: Design Expo 2015 Success: Winners, Senior Design and Enterprise Projects

See the Design Expo Summary

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MSE and BME Seminar: Biomaterial design to interrupt pathological tissue remodeling processes

Tuesday, April 28, 2015
1:15 pm – 2:15 pm
Room U113, M&M Building

Biomaterial design to interrupt pathological tissue remodeling

John & Virginia Towers Distinguished Lecture Series

Prof. William R. Wagner
University of Pittsburgh

William Wagner Abstract April 28, 2015

Tissue remodeling occurs in disease and following trauma, often yielding results that are dysfunctional and which may ultimately progress towards tissue failure. In the case of mechanically active soft tissues, the mechanical environment in which the damaged tissue heals impacts the direction and outcome of the remodeling process. To develop biomaterial-based approaches to improve soft tissue repair we have created degradable supports that act as scaffolds for new tissue generation or as temporary load bearing elements during the remodeling process.

Efforts have been directed at the adverse ventricular remodeling process that occurs following myocardial infarction resulting in dilated ischemic cardiomyopathy, and the remodeling of veins used in arterial grafting and tissue engineered blood vessel development. Two general types of supporting biomaterials have been developed and tested in at least one of these settings. In the first approach thermoplastic elastomers, typified by poly(ester urethane)urea, have been synthesized and processed to form microporous elastic patches or wraps. Molecular design parameters can be selected to tune mechanical and degradation properties. In the processing steps, composites with natural materials, such as extracellular matrix digests and components, have been generated. A second approach has focused on the development of thermoresponsive, injectable copolymers that “set up” quickly in situ to provide mechanical support to tissues under load, but then degrade to become soluble over time. The application of these materials in vivo has been shown to alter remodeling patterns and to facilitate tissue generation with associated functional improvements.

Biography: Dr. William R. Wagner is the Director of the McGowan Institute for Regenerative Medicine and a Professor of Surgery, Bioengineering and Chemical Engineering at the University of Pittsburgh. He also serves as Scientific Director of the NSF Engineering Research Center on “Revolutionizing Metallic Biomaterials” and Chief Science Officer for the Armed Forces Institute of Regenerative Medicine. He holds a B.S. (Johns Hopkins Univ.) and Ph.D. (Univ. of Texas) in Chemical Engineering. Professor Wagner is the Founding Editor and Editor-in-Chief of one of the leading biomaterials journals, Acta Biomaterialia, and is a past-president of the American Society for Artificial Internal Organs (ASAIO). Currently he serves as Chairman for the Tissue Engineering and Regenerative Medicine International Society (TERMIS), Americas region. He is a fellow and former vice president of the American Institute for Medical and Biological Engineering and has also been elected a fellow of the Biomedical Engineering Society, the International Union of Societies for Biomaterials Science and Engineering, and the American Heart Association. In 2006 he was selected to the “Scientific American 50”, the magazine’s annual list recognizing leaders in science and technology from the research, business and policy fields. His research has generated numerous patents and patent filings that have resulted in licensing activity, the formation of a company that is currently engaged in clinical trials, and University of Pittsburgh Innovator Awards in 2007, 2008, 2009, 2010 and 2014. In recent years he has been awarded the Society for Biomaterials Clemson Award for Applied Research, the Chancellor’s Distinguished Research Award by the University of Pittsburgh, and the Senior Investigator Award by TERMIS-Americas. Dr. Wagner’s research interests are generally in the area of cardiovascular engineering with projects that address medical device biocompatibility and design, tissue engineering, and targeted imaging.

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Biomedical Engineering Seminar: Capacitive Micro Machined Ultrasonic Transducers and Systems for Imaging and Surgery

Biomedical Engineering Seminar:
Jingkuang Chen, PhD, Principle Engineer, Johnson & Johnson
Thursday, February 12th, 11:00am, Fisher 132
“Capacitive Micro Machined Ultrasonic Transducers and Systems for Imaging and Surgery”
Sponsored by the Department of Biomedical Engineering

This talk will highlight the development of capacitive micromachined ultrasonic transducer (CMUT) arrays for clinical use that delivers diagnostic information, including anatomy images with a better contrast and resolution, as well as therapeutic and surgical functions not available from conventional piezoelectric tools. Examples of these devices include a tiny panoramic CMUT endoscope integrated with high-intensity focused ultrasound capability for arrhythmia diagnosis and surgery, a needle-shaped CMUT array that is smaller than a human hair for imaging, brain blood-flow-rate measurement, or hearing aids, and a CMUT photoacoustic imager. Using photon-induced acoustic waves for image reconstruction, photoacoustic imaging can capture images of blood and calcification cluster, and is exceptionally useful for identifying diseases/abnormalities related to blood, such as internal bleeding from pre-stroke or early-stage cancer. A novel architecture for photoacoustic imaging has been developed allowing light illumination through an infrared-transparent CMUT array, resulting in a compact portable modality suitable for ambulance and other field use. A broader spectrum on the clinical use of
CMUT technology will also be discussed, including the concept of wearable ultrasound patch for soft/hard tissue regeneration or wound healing.

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Biomedical Engineering Seminar: Medical Devices and Technology

Biomedical Engineering Seminar: Smita Rao, PhD
Department of Electrical Engineering, University of Texas Arlington,
Sponsored by the Department of Biomedical Engineering
Thursday, February 5th, 3:00pm, Dillman 320

Title: “Medical Devices and Technology”

The recent advances in fabrication, design and simulation and ease of access to novel techniques have driven the advances in medical devices and technologies. There is a rise in the demand for wearable or minimally invasive interventions and therapies to improve the day-to-day life of a patient. Currently, several treatment modalities suffer from the need for bulky bedside equipment that limit mobility and hamper quality of life. The cost of such care is also significant. By reducing the size of the devices, making them battery operated or wireless improves the quality of life at a fraction of the cost. In many cases, the device can be implanted in a simple outpatient procedure lowering recovery times and risks associated with post-operation infections. New and innovative diagnostic methodologies, significantly smaller device footprints and lower cost of fabrication using existing techniques have yielded promising results. Implantable wireless, batteryless sensor for gastro-esophageal reflux disease, wirelessly powered gastrostimulators, miniature nanorod sensors for detecting neuro-transmitters such as dopamine have been demonstrated. Another aspect of these advances is in the field of lab-on-chip technologies for
diagnostic applications. Microfluidics has been in the forefront of this effort and continues to provide invaluable information. Microfluidic platforms to study biological phenomenon such as cell proliferation, migration and interaction promise to yield vital clues to the development and spread of diseases like cancer, study the interaction of drugs and explore the bio-mechanic aspects of tissues.

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Biomedical Engineering Seminar: Applications of Coursework to Industrial Design and Clinical Practice: Biomedical Engineering/Science Applied to Cardiac Rhythm Disorders

Biomedical Engineering Seminar: Friday, January 30th: EERC 100, 3-4pm
D. Curt Deno, Senior Principle Scientist, St. Jude Medical Tech Center
“Applications of Coursework to Industrial Design and Clinical Practice: Biomedical Engineering/Science Applied to Cardiac Rhythm Disorders”
Sponsored by the Department of Biomedical Engineering

For the last roughly 100 years, technology has played crucial roles in advancing health care. Substantial contributions have come from academic and corporate R&D organizations–environments where learning and research have fostered the innovations that have shaped modern medicine. The speaker’s perspective includes training in both technical and biomedical disciplines. This talk intends to illustrate with examples how a good engineering or science background has repeatedly proven of value in advancing knowledge and developing products that benefit people with heart disease (form pediatric to the elderly). The speaker maintains that even despite occasional project related angst this is one of the most satisfying careers.

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