Author: College of Engineering

Bruce Lee (BioMed/HRI) is the principal investigator on a project that has received a $80,586 research and development grant from the National Science Foundation.

The project is entitled, “Biomimetic Redox Chemistry for Antiviral Application.” Caryn Heldt (ChE/HRI) is the Co-PI on this three year project.

Extract

Reactive oxygen species (ROS) can be used to disinfect a wide range of pathogens, such as viruses, bacteria, and fungi. ROS is an attractive disinfectant as it decomposes into non-toxic degradation products (water and oxygen). However, ROS is highly reactive and can be hazardous to store and transport. This project aims at utilizing a unique chemistry found in mussel adhesive proteins to create a portable biomaterial that can be activated to generate ROS.

Read more at the National Science Foundation.

Rupak Rajachar (BioMed) is the principal investigator on a project that has received a $400,343 research and development grant from the National Institutes of Health.

The project is entitled, “Targeted ROS Releasing PEG-Fibrin Composite Adhesive-Hydrogel to Control Matrix Modulation as a Wound Healing and Tissue Engineering Support.”

Bruce Lee (BioMed) is the Co-PI on this potential three-year project.

By Sponsored Programs.

Bruce Lee (BioMed) is the principal investigator on a project that has received a $434,993 research and development grant from the National Institutes of Health.

The project is entitled, “Multifunctional Nanocomposite Bioadhesive for Diabetic Wound Repair.” Xiaoqing Tang (BioSci) and Rupak Rajachar (BioMed) are Co-PI’s on this potential three-year project.

Lee is also the principal investigator on a project that has received a $102,779 research and development from the Office of Naval Research. The project is entitled, “Electro-Responsive Underwater Adhesive Based on Mussel Adhesive Chemistry.”

This is a potential three-year project totaling $524,995.

By Sponsored Programs.

Feng Zhao (BioMed) is the principal investigator on a project that has received a $347,391 research and development grant from the National Institutes of Health.

The project is entitled, “Engineered Anisotropic and Vascularized Human Cardiac Patch.”

Qinghui Chen (KIP) is the Co-PI on this potential four-year project totaling $1,505,266.

By Sponsored Programs.

Bruce Lee (BioMed) published a review article in Chemical Society Reviews entitled “Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.”

Chemical Society Reviews is the Royal Society of Chemistry’s leading reviews journal and publishes high-impact articles at the forefront of the chemical sciences. (Impact Factor: 40.443)

https://doi.org/10.1039/C9CS00285E

This review compiles state-of-the-art examples and details progress in the design and development of adhesive hydrogel materials based on mussel-inspired catechol chemistry. From a fundamental perspective, two main aspects have been examined: the role of water in undermining adhesion in hydrogels and the adhesive mechanism involving catechol-containing adhesives and coatings.

Read more…

Sangyoon Han (BioMed) is the principal investigator on a project that has received a $414,802 research and development grant from the U.S. Department of Health and Human Services National Institutes of Health.

The project is entitled, “Nascent Adhesion-Based Mechano-Transmission for Extracellular Matrix Stiffness Sensing.”

This is a potential three-year project.

By Sponsored Programs.