Advanced mass spectrometry course in Spring

Students & Faculty
I’m pleased to announce that we’ve just opened up an undergraduate level (CH4800; CRN 14633) advanced mass spectrometry course to be taught in parallel to the current graduate level (CH5240; CRN 14481).  Please note that this course is available only during the Spring semester of even years (e.g., Spring 2018, Spring 2020, etc.).
For graduate students, we also have a laboratory course (CH5241; CRN 14482) that provides hands-on experience.  The laboratory course is required for future “trusted users” of the MRI funded Orbitrap Elite MS in the Chemical Advanced Resolution Methods (ChARM) core facility.  Past students participated in a class research project to develop methods for dissolved organic phosphorus in wastewater effluent.  This year’s group will focus on the detailed molecular chemistry of Lake Effect snow.
Course Description:
The focus of this course is advanced mass spectrometry (MS) methods.  We will study a wide variety of mass analyzers including quadrupole, time of flight, ion trap, ion cyclotron resonance, and orbitrap.  Since MS analysis can only be performed on ionized molecules, a variety of analyte introduction techniques will also be studied.  Molecular identification methods including the use of tandem mass spectrometric analysis (aka MS/MS) and exact mass analysis will also be covered.  Students will then apply the fundamentals of these topics to identify unknown natural compounds from mass spectra and develop analytical strategies. 
Course Learning Objectives:
• Describe the theory of ionization and ion fragmentation.
• Compare and contrast the various ionization methods with respect to analyte structure and analytical application.
• Describe the strengths and weaknesses of several mass analyzers in terms of the elements of the instrument design and intended applications.
• Evaluate mass spectrometry data to elucidate molecular structures and/or qualitative empirical formulas and other metrics.
• Design and evaluate analytical methods, including tandem mass spectrometry methods, for various applications.
• Assimilate a literature review presentation of an advanced mass spectrometry method from the peer-reviewed literature.
Lynn R. Mazzoleni, Ph.D.

Associate Professor

Department of Chemistry and

Atmospheric Science Program
Michigan Technological University
1400 Townsend Drive
Houghton, MI 49931
(+1) 906-487-1853