{"id":12378,"date":"2025-08-01T10:14:50","date_gmt":"2025-08-01T14:14:50","guid":{"rendered":"https:\/\/blogs.mtu.edu\/gradschool\/?p=12378"},"modified":"2025-07-16T10:36:05","modified_gmt":"2025-07-16T14:36:05","slug":"distinguished-dissertation-award-nominee-xinqian-chen","status":"publish","type":"post","link":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/","title":{"rendered":"Distinguished Dissertation Award Nominee – Xinqian Chen"},"content":{"rendered":"
\n
\n \n \"\"\n <\/a>\n \n
Xinqian Chen, PhD in Integrative Physiology<\/a>, 2025<\/figcaption>\n <\/figure>\n<\/div>\n\n\n

\n We’re incredibly proud to announce that Xinqian, a recent graduate of our Kinesiology and Integrative Physiology Program, has been nominated for the CGS\/ProQuest Distinguished Dissertation Award! This nomination is a powerful testament to their exceptional research and significant contributions.\n<\/p>\n\n\n

\n Xinqian states “It is a great honor to be nominated for the 2025 CGS\/ProQuest Distinguished Dissertation Award, and I sincerely appreciate this opportunity.\n<\/p>\n\n\n

\n My passion for life sciences, especially research related to human diseases, has guided my academic journey from the beginning. After completing my undergraduate degree at Shenzhen University, I came here to pursue both my master\u2019s and Ph.D. degrees in Integrative Physiology. Under the mentorship of Dr. Zhiying Shan, I focused my doctoral research on understanding the role of brain-derived extracellular vesicles (EVs) in salt-sensitive hypertension, a major risk factor for cardiovascular disease.\n<\/p>\n\n\n

\n My dissertation, titled Exploring the Role of Brain-Derived Extracellular Vesicles in Salt-Sensitive Hypertension, investigates how EVs contribute to hypertension through their effects on the brain hypothalamic paraventricular nucleus (PVN). I demonstrated that EVs from hypertensive rats induce neuroinflammation and oxidative stress in primary neuronal cultures and in the PVN of healthy animals. Furthermore, I found that administering these EVs into the brain, in combination with high salt intake, caused persistent elevation in blood pressure and disrupted PVN function. To address this, I engineered EVs loaded with siRNA targeting the angiotensin II type 1 receptor (AT1R), which effectively reversed the hypertensive effects and reduced mitochondrial oxidative stress.\n<\/p>\n\n\n

\n This work not only revealed a novel mechanism of hypertension pathogenesis but also presented a potential therapeutic approach using EV-based targeted delivery systems. I\u2019m proud that my research offer insight into both disease mechanisms and translational strategies.
I am deeply honored by this recognition and remain committed to advancing biomedical science through curiosity-driven and impactful research, as I continue my postdoctoral work exploring the therapeutic potential of EVs.”\n<\/p>\n","protected":false},"excerpt":{"rendered":"

We’re incredibly proud to announce that Xinqian, a recent graduate of our Kinesiology and Integrative Physiology Program, has been nominated for the CGS\/ProQuest Distinguished Dissertation Award! This nomination is a powerful testament to their exceptional research and significant contributions. Xinqian states “It is a great honor to be nominated for the 2025 CGS\/ProQuest Distinguished Dissertation . . .<\/p>\n","protected":false},"author":1116,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[75],"tags":[64699],"class_list":["post-12378","post","type-post","status-publish","format-standard","hentry","category-news","tag-distinguished-dissertation-award"],"yoast_head":"\nDistinguished Dissertation Award Nominee - Xinqian Chen | Graduate School Newsblog<\/title>\n<meta name=\"description\" content=\"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Distinguished Dissertation Award Nominee - Xinqian Chen\" \/>\n<meta property=\"og:description\" content=\"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/\" \/>\n<meta property=\"og:site_name\" content=\"Graduate School Newsblog\" \/>\n<meta property=\"article:published_time\" content=\"2025-08-01T14:14:50+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1558\" \/>\n\t<meta property=\"og:image:height\" content=\"2560\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Moriah Goodall\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Moriah Goodall\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/\",\"url\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/\",\"name\":\"Distinguished Dissertation Award Nominee - Xinqian Chen | Graduate School Newsblog\",\"isPartOf\":{\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-365x600.jpeg\",\"datePublished\":\"2025-08-01T14:14:50+00:00\",\"author\":{\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/5ef22298258b663f955dfe9570d58f65\"},\"description\":\"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.\",\"breadcrumb\":{\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage\",\"url\":\"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg\",\"contentUrl\":\"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg\",\"width\":1558,\"height\":2560},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/blogs.mtu.edu\/gradschool\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Distinguished Dissertation Award Nominee – Xinqian Chen\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/#website\",\"url\":\"https:\/\/blogs.mtu.edu\/gradschool\/\",\"name\":\"Graduate School Newsblog\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/blogs.mtu.edu\/gradschool\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/5ef22298258b663f955dfe9570d58f65\",\"name\":\"Moriah Goodall\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/02f49bf142a380d634e0d5e98ecf9c852e6aea4bffc1cb741b0e7bc674d23be8?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/02f49bf142a380d634e0d5e98ecf9c852e6aea4bffc1cb741b0e7bc674d23be8?s=96&d=mm&r=g\",\"caption\":\"Moriah Goodall\"},\"url\":\"https:\/\/blogs.mtu.edu\/gradschool\/author\/mgoodall\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Distinguished Dissertation Award Nominee - Xinqian Chen | Graduate School Newsblog","description":"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/","og_locale":"en_US","og_type":"article","og_title":"Distinguished Dissertation Award Nominee - Xinqian Chen","og_description":"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.","og_url":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/","og_site_name":"Graduate School Newsblog","article_published_time":"2025-08-01T14:14:50+00:00","og_image":[{"width":1558,"height":2560,"url":"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg","type":"image\/jpeg"}],"author":"Moriah Goodall","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Moriah Goodall","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/","url":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/","name":"Distinguished Dissertation Award Nominee - Xinqian Chen | Graduate School Newsblog","isPartOf":{"@id":"https:\/\/blogs.mtu.edu\/gradschool\/#website"},"primaryImageOfPage":{"@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage"},"image":{"@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage"},"thumbnailUrl":"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-365x600.jpeg","datePublished":"2025-08-01T14:14:50+00:00","author":{"@id":"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/5ef22298258b663f955dfe9570d58f65"},"description":"Xinqian Chen, nominated for the prestigious CGS\/ProQuest Distinguished Dissertation Award! Read more about salt-sensitive hypertension.","breadcrumb":{"@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#primaryimage","url":"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg","contentUrl":"https:\/\/blogs.mtu.edu\/gradschool\/files\/2025\/07\/IMG_7781-Xinqian-Chen-scaled.jpeg","width":1558,"height":2560},{"@type":"BreadcrumbList","@id":"https:\/\/blogs.mtu.edu\/gradschool\/2025\/08\/01\/distinguished-dissertation-award-nominee-xinqian-chen\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/blogs.mtu.edu\/gradschool\/"},{"@type":"ListItem","position":2,"name":"Distinguished Dissertation Award Nominee – Xinqian Chen"}]},{"@type":"WebSite","@id":"https:\/\/blogs.mtu.edu\/gradschool\/#website","url":"https:\/\/blogs.mtu.edu\/gradschool\/","name":"Graduate School Newsblog","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/blogs.mtu.edu\/gradschool\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/5ef22298258b663f955dfe9570d58f65","name":"Moriah Goodall","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/blogs.mtu.edu\/gradschool\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/02f49bf142a380d634e0d5e98ecf9c852e6aea4bffc1cb741b0e7bc674d23be8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/02f49bf142a380d634e0d5e98ecf9c852e6aea4bffc1cb741b0e7bc674d23be8?s=96&d=mm&r=g","caption":"Moriah Goodall"},"url":"https:\/\/blogs.mtu.edu\/gradschool\/author\/mgoodall\/"}]}},"_links":{"self":[{"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/posts\/12378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/users\/1116"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/comments?post=12378"}],"version-history":[{"count":1,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/posts\/12378\/revisions"}],"predecessor-version":[{"id":12380,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/posts\/12378\/revisions\/12380"}],"wp:attachment":[{"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/media?parent=12378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/categories?post=12378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.mtu.edu\/gradschool\/wp-json\/wp\/v2\/tags?post=12378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}