Friday, October 31, 2008 3:00 – 4:00 pm
Room 610, M&M Building
Dr. Megan C. Frost
Department of Biomedical Engineering
Michigan technological University
The research in our laboratory is focused on the development of novel Snitrosothiol compounds (RSNOs) as nitric oxide (NO) donors that can use light ofdifferent wavelengths and intensities to trigger the release of NO. Preliminary datawill be presented for novel aromatic RSNOs that release NO in response to phototriggers. By altering the electronic properties of substituents on the aromatic ring,we are able to shift the specific wavelength of light needed to release NO. Work isunderway focused on developing the chemistries necessary to immobilize thesecompounds into polymeric materials so that they can be used in the fabrication ofimplantable biomedical devices such as fiber optic sensors and probes capable ofreleasing NO at continuously variable and controllable levels such that the devicesshow improved biocompatibility and enhanced performance.
Megan C. Frost joined the faculty of the Department of Biomedical Engineering asan assistant professor in August 2007. She comes to Michigan Tech from a postdoctoralposition at the University of Michigan. She holds a PhD in Analytical Chemistry from theUniversity of Michigan, an MS is Analytical Chemistry from Purdue University-Indianapolis and aBS in Biological Sciences from the University of Notre Dame. Her research interests involvedesigning nitric oxide releasing polymeric materials that exhibit reduced biological responsewhen implanted in the body and the development of intravascular and subcutaneous sensorswith these nitric oxide releasing materials that show improved in vivo performance.