Friday, March 4, 2011 3:30 pm – 4:30 pm
Room G05, Rekhi Hall
Bruce P. Lee
Director of New Technology
Nerites Corporation, Madison, WI
Bioadhesives have a wide range of important applications in the biomedical field. Tissueadhesives simplify complex surgical procedures to achieve effective wound closure and surgicalrepair. Despite these important functions, currently available adhesives seldom meet the basicrequirements for in vivo applications because of possible disease transmission, poor adhesivequality, or toxicity concerns. Thus, there is an ongoing need for the development of tissueadhesives with improved characteristics. Nature provides many outstanding examples ofadhesive strategies from which chemists and materials scientists can draw inspiration in theirpursuit of new biomaterials. Of particular interest is the mussel adhesive protein (MAP) secretedby marine mussels. MAP is initially secreted as a proteinaceous fluid, and then subsequentlyharden in situ to form an adhesive plaque, which allow mussels to bind tenaciously to varioustypes of surfaces underwater. One of the unique structural features of MAP is the presence of L-3,4-dihydroxyphenylalanine (DOPA), an amino acid post-translationally modified from tyrosine,which is believed to fulfill the dual role as the adhesive moiety and the crosslinking precursor.Our research focuses on the incorporation of DOPA and its derivatives in creating syntheticmimics of MAPs for various medical applications. In this seminar, I will discuss the design andapplication of these biomimetic adhesive materials.