Thursday February 18, 2010 3:00 – 4:00 p.m.
ME-EM Building, Room 112
Silvia Salinas Blemker
University of Virginia
Skeletal muscle has a beautiful hierarchical structure that enables thousands of musclecells to work in concert and actuate movement. In my presentation, I will describe ourcomputational framework for analyzing muscle structure and function at multiple levelsofthis hierarchy, including fibers, fascicles, and whole muscle. The framework combinesmodeling efforts in several areas, including the development of a constitutive model fordescribing the nonlinear, active, anisotropic behavior of muscle tissue, the application ofmicromechanical modeling methods for deriving muscle tissue properties, and theimplementation of image-based modeling techniques for creating and validating subjectspecific muscle models. This modeling framework can be used to explore how thestructure and properties of muscle fibers, muscle fascicles, muscle tissue, tendons, andwhole muscle affects function. For example, we are creating models to (i) understandhow fiber and fascicle geometry affect muscle tissue properties and force-generatingability, and (ii) explore the effects of internal muscle-tendon morphology on muscleinjury susceptibility.