Synthesis of Taiwaniadducts I and J

Xin Yan
Original Research Proposal
Michigan Technological University
Department of Chemistry
Advisor-Dr. Lanrong Bi
Thursday, February 26, 2015
9:00 am Admin Building Room 404
Abstract
The Taiwaniadducts I and J, as cycloadducts of terpene quinones from taiwania cryptomerioides, will be synthesized. These two compounds are isolated from Taiwania cryptomerioides hayata, a large coniferous evergreen species common to Taiwan. They have potential in medical applications due to the breadth of their biological activities. However, low yields of these naturally extracted compounds limits further research on their biological activities and no synthetic approaches to these two compounds have been reported before. Herein, we design a synthetic route which can provide adequate quantities of target compounds for further biological studies. Moreover, the design methodology involved in this proposal may show a reasonable approach to the synthesis of this kind of cycloadducts.


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