Archives—November 2019

Be Brief: Glow

Changes in pH cause the rhodol dyes to glow differently, offering insight into diseases that affect mitophagy.Fluorescent dyes help scientists see the inner workings of disease. In a new paper by Haiying Liu (Chem), Rudy Luck (Chem) and Thomas Werner (Bio Sci)—along with student researchers—they examine the efficacy of a rhodol-based fluorescent dye.

Diseases like Alzheimer’s and certain kinds of cancers affect the powerhouses of cells — mitochondria. To keep these powerhouses working efficiently, cells remove damaged mitochondria. This process, called mitophagy, is like a cell taking out the trash. In diseased cells, the garbage piles up and the cell’s pH changes. The rhodol dye responds to pH changes and glows brighter.

Luck adds that he considers it a privilege to be able to contribute to Liu’s attempts to find commercially viable probes. The team also acknowledges that the High-Performance Computer system Superior, managed under Director Gowtham, has advanced the research considerably.

Read more about the next steps of this research on the campus research blog Unscripted and celebrate National Chemistry Week with other Unscripted reads about surface chemistry, the science of brewing and mass spectrometry.


In Print

Business woman working on laptop computer at ergonomic standing desk. Female professional working at her desk with male colleague working at the back.John Durocher (BioSci)Steve Elmer (KIP) PhD student Ian Greenlund, recent graduate Piersan Suriano and Jason Carter published The paper titled “Chronic Standing Desk Use and Arterial Stiffness” in this month’s issue of the Journal of Physical Activity and Health.

The results of the study indicate that using a standing desk for more than 50% of the workday did not effectively reduce arterial stiffness. The study confirms that aerobic fitness reduces arterial stiffness, and that aging increases arterial stiffness. The authors wish to thank faculty and staff members from around campus who participated in this study.

The article can be viewed free.