In Print: Jill Olin Co-Authors Article Suggesting Subsequent Studies Spotlighting Sharks

Jill Olin
Jill Olin

Jill Olin was co-author of a paper that recently appeared in the Journal of Fish Biology. The co-authors argue that research about sharks and their populations needs to be expanded in the face of recent spikes in shark-human interactions in the coastal areas of New York. In addition, ECO Magazine recently mentioned the paper in a story about shark attacks along the New York coast.

Dr. Olin is a community ecologist who studies the processes that affect the structure and stability of ecosystems. She studies issues in coastal marine and freshwater ecosystems due to the diversity and economic importance of species inhabiting these environments and the fact that they are threatened by anthropogenic influences. She teaches courses in Ecology and Evolution, Marine Ecology, and Ecogeochemical Tracer Techniques.

About the Biological Sciences Department

Biological scientists at Michigan Technological University help students apply academic concepts to real-world issues: improving healthcare, conserving biodiversity, advancing agriculture, and unlocking the secrets of evolution and genetics. The Biological Sciences Department offers seven undergraduate degrees and three graduate degrees. Supercharge your biology skills to meet the demands of a technology-driven society at a flagship public research university powered by science, technology, engineering, and math. Graduate with the theoretical knowledge and practical experience needed to solve real-world problems and succeed in academia, research, and tomorrow’s high-tech business landscape.

Questions? Contact us at biology@mtu.edu. Follow us on Facebook and Instagram for the latest happenings.

Brigitte Morin, 2023 University Diversity Award Winner

Brigitte Morin
Brigitte Morin

Congratulations to Brigitte Morin: the winner of the 2023 University Diversity Award!!

Brigitte attended Michigan Tech in 2001, where she received a Bachelor’s degree in Medical Laboratory Science (MLS). She also received a certificate in Secondary Education and minors in both General Science and Spanish. Following graduation in 2006, Brigitte taught high school Biology for six years in Illinois. After receiving an MS degree in Biology from Northern Illinois University, Brigitte has returned to Michigan Tech as a lecturer, primarily in the MLS program.

The Michigan Technological University Diversity Award recognizes the accomplishments of a faculty and/or staff member of the University who contributes to diversity, equity, and inclusion through exemplary leadership and actions. Recipients will demonstrate a commitment to diversity, equity, inclusion, and sense of belonging (DEIS) as through recruitment and retention efforts, teaching, research, culturally responsive mentorship, inclusive programming, diversity literacy, community outreach activities, or other initiatives.

Casey Huckins, Brigitte Morin, and Amy Marcarelli
Casey Huckins, Brigitte Morin, and Amy Marcarelli

About the Biological Sciences Department

Biological scientists at Michigan Technological University help students apply academic concepts to real-world issues: improving healthcare, conserving biodiversity, advancing agriculture, and unlocking the secrets of evolution and genetics. The Biological Sciences Department offers seven undergraduate degrees and three graduate degrees. Supercharge your biology skills to meet the demands of a technology-driven society at a flagship public research university powered by science, technology, engineering, and math. Graduate with the theoretical knowledge and practical experience needed to solve real-world problems and succeed in academia, research, and tomorrow’s high-tech business landscape.

Questions? Contact us at biology@mtu.edu. Follow us on Facebook and Instagram for the latest happenings.

In Print: Erika Hersch-Green and Angela Walczyk

Congratulations to Dr. Angela Walczyk (recent Ph.D. from Biological Sciences) and her advisor Dr. Erika Hersch-Green for their two new publications! You can access the papers here:

Erika Hersch-Green
Erika Hersch-Green

1. Exciting findings that genome size can affect resource requirements and genomic/transcriptomic functional trait trade-offs. 

Abstract

Premise: Increased genome-material costs of N and P atoms inherent to organisms with larger genomes have been proposed to limit growth under nutrient scarcities and to promote growth under nutrient enrichments. Such responsiveness may reflect a nutrient-dependent diploid versus polyploid advantage that could have vast ecological and evolutionary implications, but direct evidence that material costs increase with ploidy level and/or influence cytotype-dependent growth, metabolic, and/or resource-use trade-offs is limited.

Methods: We grew diploid, autotetraploid, and autohexaploid Solidago gigantea plants with one of four ambient or enriched N:P ratios and measured traits related to material costs, primary and secondary metabolism, and resource-use.

Results: Relative to diploids, polyploids invested more N and P into cells, and tetraploids grew more with N enrichments, suggesting that material costs increase with ploidy level. Polyploids also generally exhibited strategies that could minimize material-cost constraints over both long (reduced monoploid genome size) and short (more extreme transcriptome downsizing, reduced photosynthesis rates and terpene concentrations, enhanced N-use efficiencies) evolutionary time periods. Furthermore, polyploids had lower transpiration rates but higher water-use efficiencies than diploids, both of which were more pronounced under nutrient-limiting conditions.

Conclusions: N and P material costs increase with ploidy level, but material-cost constraints might be lessened by resource allocation/investment mechanisms that can also alter ecological dynamics and selection. Our results enhance mechanistic understanding of how global increases in nutrients might provide a release from material-cost constraints in polyploids that could impact ploidy (or genome-size)-specific performances, cytogeographic patterning, and multispecies community structuring.

Angela Walczyk
Angela Walczyk

2. Finding that tetraploid Giant Goldenrods may be pre-adapted to be good invaders but that polyploidy per se does not increase phenotypic plasticity. 

Abstract

Polyploidy commonly occurs in invasive species, and phenotypic plasticity (PP, the ability to alter one’s phenotype in different environments) is predicted to be enhanced in polyploids and to contribute to their invasive success. However, empirical support that increased PP is frequent in polyploids and/or confers invasive success is limited. Here, we investigated if polyploids are more pre-adapted to become invasive than diploids via the scaling of trait values and PP with ploidy level, and if post-introduction selection has led to a divergence in trait values and PP responses between native- and non-native cytotypes. We grew diploid, tetraploid (from both native North American and non-native European ranges), and hexaploid Solidago gigantea in pots outside with low, medium, and high soil nitrogen and phosphorus (NP) amendments, and measured traits related to growth, asexual reproduction, physiology, and insects/pathogen resistance. Overall, we found little evidence to suggest that polyploidy and post-introduction selection shaped mean trait and PP responses. When we compared diploids to tetraploids (as their introduction into Europe was more likely than hexaploids) we found that tetraploids had greater pathogen resistance, photosynthetic capacities, and water-use efficiencies and generally performed better under NP enrichments. Furthermore, tetraploids invested more into roots than shoots in low NP and more into shoots than roots in high NP, and this resource strategy is beneficial under variable NP conditions. Lastly, native tetraploids exhibited greater plasticity in biomass accumulation, clonal-ramet production, and water-use efficiency. Cumulatively, tetraploid S. gigantea possesses traits that might have predisposed and enabled them to become successful invaders. Our findings highlight that trait expression and invasive species dynamics are nuanced, while also providing insight into the invasion success and cyto-geographic patterning of S. gigantea that can be broadly applied to other invasive species with polyploid complexes.

New Funding: Amy Marcarelli and Michelle Kelly

Amy Marcarelli is the principal investigator (PI) on a project that has received a $300,000 research and development grant from the National Science Foundation.

The project is titled “MSA: Quantifying whole-stream denitrification and nitrogen fixation with integrated modeling of N2 and O2 fluxes.”

Michelle Kelly is a co-PI on this potential two-year project.

Amy is an ecosystem ecologist with interests in energy and biogeochemical cycles in freshwaters. Her research program blends basic and applied research and integrates across aquatic habitats, including streams, rivers, wetlands, lake littoral zones, and the nearshore regions of the Great Lakes. Dr. Marcarelli’s past and future research trajectory is governed by an interest in understanding the role of small, poorly quantified fluxes or perturbations on ecosystem processes and in linking those ecosystem processes to the underlying structure of microbial, algal, macrophyte, and animal communities.

Congratulations Dr. Marcarelli and Michelle Kelly!

Amy Marcarelli
Amy Marcarelli
Michelle Kelly
Michelle Kelly

Nursing Student Advice from Sarah Kuiper

Baby on sled, Sarah holding a large dog
Exploring the Keweenaw winters!

Sarah Kuiper is a fourth-year nursing student, getting her bachelor’s degree in nursing (BSN) who found that nursing is much more than taking vitals and giving shots. Sarah recounts her experiences as a BSN student and her advice for nursing students.

Why did you choose to go into nursing? Was there a life experience you had? Tell me about it.

I decided to go into nursing after the birth of my first child. Before that experience, I thought a nurse was just someone who gave shots and took vitals. After my daughter’s birth, I learned that nursing is really so much more than that. They are not only caregivers but teachers and advocates. That encounter not only taught me that nursing was in my future but also the significant positive impact that one person can have on the healthcare experience.

The concept of an academic family enhances the learning experience for nursing students. How did your academic family help you in your first years in the program?

My academic family helped me during the first few years by providing study tips, a listening ear, and by giving me a great understanding of what it would take to be successful. They checked in on us to see how we were doing and were always our biggest cheerleaders.

In what way did the academic family concept help you as an upperclassman mentoring and giving advice to newer nursing students?

By providing tutoring and helping our “kids” in the skills lab, I gained confidence in my own skills and knowledge. It also helped me retain what I learned during the first years in the program.

Sarah Kuiper standing with a camera next to a river
Sarah Kuiper, Senior

Where did/will you complete the majority of your clinical hours?

We have a huge variety of clinical locations. I spent a significant amount of time at both hospitals, as well as various local clinics, schools, long-term care, and hospice facilities. Our mental health clinicals included hours at a residential substance abuse house. We also helped to teach life skills to those with developmental disabilities. My most memorable experiences have been when we traveled to Marquette for clinical rotations in intensive care, NICU, and behavioral health units. Each clinical site has a different focus, and the places we are sent depend on what classes we are taking that semester.

What are some of the things you do during clinicals? What do you enjoy the most about the experience?

The things we get to do in clinical progress throughout the program. Only once we have been checked off on a skill in the lab can we do it in the clinical setting. We started doing basic care such as providing hygiene, transfers, and taking vitals. We do patient assessments and learn to document according to the facility that we are at. Skills progress to the point where we start IVs, insert catheters and NG tubes, and even pass medications alongside an RN. In addition to skills, I have gotten to observe multiple surgeries and even a few births! The part I enjoy most is working alongside nurses in our community.

What have you learned about yourself from the clinical experience?

Sarah with baby on her back walking outside in the winter
Sarah enjoying the outdoors

I’ve learned I will never stop learning. Nursing education goes far beyond the classroom, and I have only scratched the surface of all there is to know. Clinicals keep me humble and focused on the main goal of providing the best care possible. Also, the great variety of clinical locations helped me learn where I love to be and want to work in the future.

How do you think the clinical experience has set you up for success in your after-graduation plans?

The clinical experience gives me the opportunity to practice skills in a real nursing setting. As someone who plans to work locally after graduation, each clinical site could be a future place of employment. In addition to getting a basic understanding of the job at that facility, clinical is a chance to network with future co-workers and employers.

What advice do you have for nursing students getting ready to go through clinical?

Study up for your clinical day in order to come prepared. If you know you are going to work with a particular diagnosis, see a specific procedure, or pass a certain medication, look up everything you can on it the night before. Write your self notes on the topic and write down any questions you may have. Be prepared to DO things, seek out opportunities to practice skills, and take the initiative to give yourself the best possible learning experience.

What advice do you have for high schoolers who are considering getting a BSN?

Remember WHY you want to be a nurse and be prepared to work hard. Use all the resources available to you, and reach out for help when you need it.

New Funding: Yan Zhang

Yan Zhang
Yan Zhang

Yan Zhang is the principal investigator on a project that has received a $469,500 research and development grant from the National Institutes of Health.

The project titled “High urinary phosphate induces TLR4-mediated inflammation and cystogenesis in polycystic kidney disease” is a potential two-year project.

Autosomal dominant polycystic kidney disease (ADPKD) is the most common, potentially lethal genetic disorder characterized by the progressive enlargement of numerous fluid-filled cysts and the development of interstitial inflammation and fibrosis. ADPKD is caused by the mutation of PKD1 or PKD2 gene. Approximately 50% of patients progress to end-stage renal disease by middle age and require dialysis or renal transplantation. Currently, treatment options for ADPKD patients are limited; thus, the development of new effective therapies is urgent. Dr. Zhang’s research lab investigates the role of innate immunity in the pathological microenvironment of ADPKD and the potential therapeutic effects of manipulating innate immunity. Dr. Zhang’s lab shows interest in determining the function of polycystin-1 encoded by PKD1.

Congratulations Dr. Yan Zhang!

About the Biological Sciences Department

Biological scientists at Michigan Technological University help students apply academic concepts to real-world issues: improving healthcare, conserving biodiversity, advancing agriculture, and unlocking the secrets of evolution and genetics. The Biological Sciences Department offers seven undergraduate degrees and three graduate degrees. Supercharge your biology skills to meet the demands of a technology-driven society at a flagship public research university powered by science, technology, engineering, and math. Graduate with the theoretical knowledge and practical experience needed to solve real-world problems and succeed in academia, research, and tomorrow’s high-tech business landscape.

Questions? Contact us at biology@mtu.edu. Follow us on Facebook and Instagram for the latest happenings.

Swift Strides of Science: Human Biology Student Outpaces Opponents in the Canal Run

Ingrid Seagren
Ingrid Seagren, Canal Run Winner and Human Bio Major

Ingrid Seagren competed in the Canal Run 5K, winning the women’s category and finishing 5th overall. She is going into her sophomore year pursuing a major in Human Biology with minors in pre-health and German. After she graduates, she plans to go to medical school and eventually become a physician. Plus, Ingrid is very active in the local community: 2023 Strawberry Fest Queen candidate, Michigan Tech Cross Country and Track and Field runner, and outdoor enthusiast.

Ingrid has volunteered with the Let’s Eat Community Meals through her church. As a high school student, she was a member of the Interact Club and was involved in numerous service activities, such as making Veteran’s Day Baskets and hosting Fun Days for elementary school students.

Ingrid is also a good student. She was named to Michigan Tech’s Dean’s List in both the Fall 2022 and Spring 2023 semesters and was recognized as a member of the Fall 2022 GLIAC Academic All-Excellence Team. As a high school student, she was a member of the National Honor Society.

In her free time, Ingrid enjoys Nordic skiing, waterskiing, hiking, and spending time with friends and family. Congratulations to Ingrid on her running, community and academic accomplishments!

Amy Marcarelli is the recipient of MTU’s 2023 Distinguished Teaching Award in the Associate Professor/Professor category 

Amy Marcarelli
Amy Marcarelli

Amy Marcarelli is a professor of biological sciences and an ecosystem ecologist with an interest in energy and biogeochemical cycles in freshwater bodies. She received her bachelor’s in biology from Colgate University and her Ph.D. in ecology from Utah State. She is the director of both the Ecosystem Science Center and the Aquatic Analysis (AQUA) shared facility at Michigan Tech. Her research applies across aquatic habitats, including streams, rivers, wetlands, lake littoral zones — the sloping area where sunlight reaches from the lake’s surface all the way to the sediment, located between the shore and deeper water — and the nearshore regions of the Great Lakes.

“Amy Marcarelli is a true example of the teacher-scholar model. She maintains an active research program studying ecology of aquatic ecosystems and has administrative duties as the director of our Ecosystem Science Center on campus. Yet she also devotes vast time and talent to doing an outstanding job in the classroom, introducing our students to the remarkable ecology of Lake Superior, involving them by the dozens in research in her laboratory, and preparing students for graduate school and careers. Michigan Tech is fortunate to have Dr. Marcarelli on our faculty.”

David Hemmer, Dean of the Michigan Tech College of Sciences and Arts

Catherine Rono Receives 2023 Songer Research Award

Matthew Songer (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA). This will be used to support a research project competition, the Songer Research Award for Human Health, for undergraduate and graduate students. Remembering their own eagerness to engage in research during their undergraduate years, the Songers established these awards to stimulate and encourage opportunities for original research by current Michigan Tech students. This is the sixth year of the competition.

Students may propose an innovative medically-oriented research project in any area of human health. The best projects will demonstrate the potential to have a broad impact on improving human life. This research will be pursued in consultation with faculty members within the College of Sciences and Arts. The Songers’ gift will support one award for undergraduate research ($4,000) and a second award for graduate research ($6,000). Matching funds from the College will allow two additional awards.

Catherine Rono
Catherine Rono

What are you studying and why?

I am currently pursuing a Ph.D. in Biological Sciences with a specialization in Cancer Biology. My decision to focus on Cancer Biology stems from a profound passion and unwavering interest in cancer research. I strongly believe that advancing scientific knowledge in this field is crucial for improving human health and making a significant impact on society.

Having witnessed the devastating effects of cancer firsthand, I was deeply motivated to dedicate my career to understanding and combating this disease. The global impact of cancer and the challenges it presents have only intensified my determination to make a meaningful difference in the lives of those affected. Being part of the scientific community and working towards finding solutions to this global health concern is both a privilege and a responsibility that I take to heart.

Are you getting the award to continue your research?

I am truly honored to be selected as the recipient of the 2023 Songer Research Award for Human Health in the amount of $6,000. This prestigious award will support my research that aims to understand the mechanisms associated with the loss of Liver Kinase B1 (LKB1) function in Non-Small Cell Lung Cancer (NSCLC). Specifically, I aim to examine the effect of LKB1 loss in sensitizing NSCLC cell lines to Phosphodiesterases 3A (PDE3A) modulators and its role in tumorigenesis. Through these investigations, I hope to uncover valuable insights that will aid in proposing novel biomarker candidates for the treatment of patients with LKB1-deficient cancers. Ultimately, this study will help to contribute to the advancement of personalized and effective therapeutic approaches.

What does the Songer Award mean to you?

This prestigious award holds immense significance for me as it validates the importance of my research and also provides the necessary resources to further contribute to this vital field of study.

I would like to extend my sincere appreciation to Matthew Songer and Laura Songer for their generous donation and their commitment to supporting groundbreaking research in human health. The confidence and trust that has been placed in me through this award inspires me to push the boundaries of scientific exploration and strive for excellence in my work.

I would also like to express my gratitude to the esteemed panel of judges and reviewers who evaluated the applications. Their time, expertise, and dedication are greatly appreciated.

Lastly, I am indebted to my mentor, colleagues, research team, and the entire Biological Sciences Department for their guidance, encouragement, and invaluable contributions. Their support has been instrumental in the progress I have made thus far. I look forward to their continued collaboration as I continue with my research journey.

Catherine Rono is an HRI Fellowship Winner

Catherine Rono HRI Fellowship
Catherine Rono HRI Fellowship Winner

Ph.D. Student in Biological Sciences, Catherine Rono, continues to be recognized for excellence. Rono is the winner of the Summer 2023 HRI Graduate Student Fellowship.

Rono stood out among the applicants. Rono published a first-author peer-reviewed article, “A dynamic compartment model for xylem loading and long-distance transport of iron explains the effect of kanamycin on metal uptake in Arabidopsis,” following her undergraduate years at Spelman College. She also won several awards and scholarships.

“The proposal is to screen essential molecules that work together with PDE3-modulator to induce apoptosis of LKB1-mutated tumor cells and to understand the molecular mechanism. The findings are likely useful for precise applications of target therapy relating to the LKB1-regulated cellular metabolisms,” said the award committee. “The project is clearly laid out.”

Health Research Institute (HRI) Graduate Fellowships were created to assist with the cost of graduate studies. Fellowships are awarded three times per year in the Fall, Spring, and Summer terms, with a limit of one award per student of up to $5000 to be used in one semester. 

What are you studying and why?

I am currently pursuing a Ph.D. in Biological Sciences with a focus on Cancer Biology. My decision to focus on this field is deeply rooted in a personal experience I had during my childhood, where I witnessed my beloved aunt battle against ovarian cancer, which tragically claimed her life. This traumatic event left an indelible mark on me and sparked an unwavering passion to make a meaningful contribution to cancer research.

Through my research, I aim to uncover the complexities of this disease and develop innovative approaches for its diagnosis, treatment, and prevention. I hope to contribute to the growing body of knowledge in the field of cancer, working towards improved patient outcomes and, ultimately, a future where cancer is no longer a devastating threat. It is my firm belief that by dedicating myself to this field, I can honor the memory of my aunt and positively impact the lives of countless individuals and families affected by cancer.

Do you plan to continue research with this award?

I am incredibly grateful and honored to have been chosen as the recipient of the Summer 2023 HRI Graduate Fellowship award in the amount of $5,000. This prestigious recognition will provide invaluable support for my research work focused on exploring and uncovering novel metabolic components and biomarkers within the Liver Kinase B1 (LKB1) signaling pathway.

Through rigorous experimentation and analysis, I aim to elucidate the regulatory functions of LKB1 in suppressing the expression of key proteins associated with promoting apoptosis. By unraveling these intricate mechanisms, my research findings have the potential to make substantial contributions to the development of targeted therapies, and personalized medicine approaches for the treatment of patients with LKB1 mutated cancers. The ability to tailor treatments to individual patients based on their specific genetic profiles and molecular characteristics holds great promise for improving patient outcomes and reducing the burden of cancer worldwide.

What does the HRI Fellowship mean to you?

The HRI Graduate Fellowship award is a tremendous honor and a testament to the significance and potential impact of my research work. It not only acknowledges the value of my research but also provides the necessary resources and connections to further drive my work forward. I am deeply grateful for this recognition and committed to utilizing this opportunity to make a meaningful and lasting impact in the field of cancer research.

Furthermore, I would like to express my deepest appreciation to the entire HRI community, my mentor, my colleagues, the research team, and the Biological Sciences Department. I am truly fortunate to be surrounded by such brilliant and dedicated individuals. Their encouragement and support have been instrumental in my growth as a researcher.