Tag: National Institutes of Health

In Print – Thomas Werner Journal of Photochemistry and Photobiology

Dr. Thomas Werner and a team of researchers recently published a paper in the Journal of Photochemistry and Photobiology B: Biology.

This team is comprised of Ph.D. students Adenike Olowolagba and Dilka Arachchige, Research Scientist Sushil Dwivedi (Chem), undergraduate students Ashlyn Colleen Beatty and Joseph Peters, high school students Crystal Wang and Alicia Guo, Associate Professor Thomas Werner (BioSci), and Associate Professor Rudy Luck and Professor Haiying Liu (both Chem).

The title of the paper is “Dynamic Insights into Mitochondrial Function: Monitoring Viscosity and SO2 Levels in Living Cells.”

This research was funded by the National Institute of General Medical Sciences, National Institutes of Health, through Award Numbers 2R15GM114751 and R15GM114751 (Liu), and R15 GM146206-01 (Liu and Luck). The National Science Foundation also provided support through Award Number 2117318, which made it possible to purchase a new NMR spectrometer for the characterization of the chemical structures of the fluorescent probes, with Liu as a co-PI. High-performance computational calculations for the fluorescent probes were completed using the infrastructure at Michigan Tech.

About Thomas Werner

Thomas Werner
Thomas Werner

Very broadly defined, Dr. Thomas Werner is an entomologist who works on different biological questions in drosophilids (“fruit flies”) and lepidopterans (butterflies and moths). One quarter of his research has been published in the journals: Nature, Science, Cell, and PNAS. Werner has received more than $900,000 in total funding, most of which came from the NIH and NSF. He has research-mentored 107 undergraduate students and 7 graduate students. He was bestowed with the state-wide Michigan Distinguished Professor of the Year Award 2021. Dr. Werner has also won Michigan Tech’s Distinguished Teaching Award twice (only three other faculty have won it twice in the history of Michigan Tech) for teaching Immunology, Genetics, Genomics, and Developmental Biology. He also discovered a new species of fruit fly, which he named after his student Tessa Steenwinkel, who won 9 research awards (e.g., the NSF Graduate Research Fellowship and the Barry Goldwater Fellowship) and published 15 articles/books under Thomas’s mentorship. The species is called Amiota tessae. Furthermore, Dr. Werner is the founder of the open-access book series “The Encyclopedia of North American Drosophilids”, which serves the Drosophila research community, students, and teachers with currently three published volumes and nearly 10,000 worldwide downloads. These books transformed two campus libraries (U. of Rochester, NY and Michigan Tech) into open-access book publishers, promoting science and education at no cost.

About the Biological Sciences Department

Biological scientists at Michigan Technological University help students apply academic concepts to real-world issues: improving healthcare, conserving biodiversity, advancing agriculture, and unlocking the secrets of evolution and genetics. The Biological Sciences Department offers seven undergraduate degrees and three graduate degrees. Supercharge your biology skills to meet the demands of a technology-driven society at a flagship public research university powered by science, technology, engineering, and math. Graduate with the theoretical knowledge and practical experience needed to solve real-world problems and succeed in academia, research, and tomorrow’s high-tech business landscape.

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NIH Grant Helps Dr. M. Tang Explore Cancer Mechanisms and Novel Treatments

Mark Tang
Mark Tang

Xiaohu (Mark) Tang’s Laboratory of Cancer Metabolism and Functional Genomics is using a three-year $413,090 grant from the National Institutes of Health to find ways to optimize the efficacy of targeted cysteine therapy and broaden its application for the treatment of different subtypes of breast cancer. Tang is an assistant professor of Biological Sciences. He earned his Ph.D. at The Weizmann Institute of Science. Haiying Liu, Professor of Chemistry, is a co-investigator on this project.

“Targeted cancer therapy is an emerging trend in precision cancer medicine,” Tang explains. “It uses the specific genetic makeup of a patient’s tumor to select the safest and most effective personalized treatment, instead of the traditional symptom-driven practice of medicine. Identifying and targeting metabolic vulnerabilities in cancer is a promising therapeutic strategy.”

The NIH grant will also provide research-based training for undergraduates and graduate students in Biological Sciences and the Biochemistry and Molecular Biology programs. “The work will enable students to understand the complexity of cancer and motivate them to seek novel strategies to improve health issues,” says Tang.

Tang’s lab works to characterize the deregulation of cancer metabolism and the role of nutrients during cancer initiation and progression. He is working to understand the underlying mechanisms of cancer to pursue workable alternative treatments for patients. He also hopes that a better understanding of diet-cancer interactions could establish a strategy for long-term cancer prevention.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Paul Goetsch Receives NIH Grant to Study Cell Cycle Regulation

Dr. Goetsch assisting a graduate student in the lab

Assistant Professor Paul Goetsch received a $423,381 grant from the National Institutes of Health. Dr. Goetsch will study how the DREAM transcriptional repressor complex regulates the cell cycle of cellular progression and cellular quiescence.

Cellular division is extremely important as an organism grows to maturity, but just as important are the mechanisms that stop cells from dividing. Dysfunction in cellular quiescence generally leads to the development of cancer cells, Goetsch explains.

Working in the model system Caenorhabditis elegans, a 1 mm-long transparent nematode, the Goetsch lab is using CRISPR/Cas9-mediated genome editing to disrupt how the DREAM complex forms and test how that affects its function. “By exploiting advances in genomic editing and genetic tools in a tractable model system, we will gain new insights into how the DREAM complex protects cellular and organismal health,” says Goetsch.

Another part of the grant supports bringing research directly into the classroom for Biological Sciences students in the second-year genetics lab. Goetsch and his colleagues are implementing Course-based Undergraduate Research Experiences (CUREs). These are used to provide students a glimpse into research opportunities within the department.

In Spring 2021, Goetsch and his student Emily Washeleski developed a unique experiment combining C. elegans genetics with environmental microbiology. “We are continuing to expand upon our CURE approach to provide students equitable access to research experience as a cornerstone of their professional development within the department,” Goetsch says.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.