T Synthesis of Isobractatin and Neobractatin

Shanshan Hou
Original Research Proposal
Michigan Technological University
Department of Chemistry
Advisor- Dr. Lanrong Bi
Tuesday April 21, 2015
9:00 am
Chem-Sci 106

T Synthesis of Isobractatin and Neobractatin

Abstract
The new Garcinia derivatives, neobractatin and isobractatin, will be synthesized. These compounds are caged-prenylxanthones which are isolated from Chinese native Garcinia bracteata. They displayed strong inhibition of cancer cells, which could significantly induce cell apoptosis and inhibit autophagy. However, the compounds which are extracted from the Chinese native Garcinia species have very low yield. Total synthesis of these derivatives will provide adequate quantities for biological studies. In addition, the new synthetic methodologies could not only produce the target compounds but also give rise to their isomers which could be potential anti-tumor candidates and used for future research.


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