A team from the Department of Chemistry, led by Associate Professor Tatyana Karabencheva-Christova and including Ph.D. student Ann Varghese (first author); Sodiq Waheed ’23 (Ph.D. Computational Chemistry, currently a researcher at Eli Lilly in Indianapolis, Indiana); postdoctoral researcher Koteswararao Gorantla; and undergraduate students Isabella DiCastri, Ciara LaRouche and Brendan Kaski, has published an article in the Journal of Physical Chemistry B.
The article is titled “Catalytic Mechanism of Collagen Hydrolysis by Zinc(II)-Dependent Matrix Metalloproteinase-1”
Professor Gregg Fields from Florida Atlantic University is a collaborator in this study.
The study reveals the catalytic mechanism of collagen hydrolysis by matrix metalloproteinase-1 (MMP-1), an extensive target for drug design, for the first time via a multilevel computational chemistry approach. The article was featured as a supplementary cover. The authors thank Sarah Atkinson (RD) for assisting with cover image preparation. The study is funded by NIH grant 2R15GM132873-02.
About the Chemistry Department at Michigan Technological University
Chemists at Michigan Technological University help students apply academic concepts to real-world issues and advance research making contributions to health and well-being, environmental protection, responsible use of materials, and climate stabilization. The Chemistry Department offers five undergraduate degrees, an MS and PhD in Chemistry, and an accelerated MS. Supercharge your chemistry skills to meet the demands of a technology-driven society at a flagship public research university powered by science, technology, engineering, and math. Graduate with the theoretical knowledge and practical experience needed to solve real-world problems and succeed in academia, research, and tomorrow’s high-tech business landscape.
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