A team from the Department of Chemistry has published an article in Chemical Science, the flagship journal of the Royal Society of Chemistry.
The team is led by Associate Professor Tatyana Karabencheva-Christova and includes Ph.D. student Anandhu Krisnan; Ph.D. graduate Sodiq Waheed ’23, currently a researcher at Eli Lilly in Indianapolis, Indiana; and Ph.D. graduate Ann Varghese ’23, currently a postdoctoral researcher at the National Center for Toxicological Research, Food and Drug Administration in Jefferson, Arkansas. Additionally, Professor Christopher J. Schofield from the University of Oxford, U.K. is a collaborator in this study.
The article is titled “Unusual Catalytic Strategy by Non-Heme Fe(II)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase AspH.”
The study reveals the origin of an unusual catalytic strategy adopted by the non-heme Fe(II)/2-oxoglutarate-dependent aspartyl hydroxylase (AspH), an enzyme emerging as a promising target for anticancer therapy.
The study is funded by NIH grant 2R15GM132873-02.
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