Day: April 23, 2024

Karabencheva-Christova Lab Reveals Molecular Mechanism of Cancer-Associated Enzyme

Cover page and images of Karabencheva-Christova's New Study
Karabencheva-Christova Publishes New Study
Tatyana Karabencheva-Christova
Associate Professor

A recent research article by Karabencheva-Christova’s group was showcased on the back cover of Chemical Science, the flagship journal of the Royal Society of Chemistry (RSC).

The team led by Dr. Karabencheva-Christova includes Ph.D. students Anandhu Krisnan (first author) and Fathima Hameed Cherilakkudy; Ph.D. graduate Sodiq Waheed ’23, currently a researcher at Eli Lilly in Indianapolis, Indiana; and Ph.D. graduate Ann Varghese ’23, currently a postdoctoral researcher at the National Center for Toxicological Research, Food and Drug Administration (FDA), in Jefferson, Arkansas. Professor Christopher J. Schofield from the University of Oxford, U.K., was a collaborator on the study.

The research illuminates the origin of the atypical catalytic strategy employed by the human non-heme Fe(II)/2-oxoglutarate-dependent dioxygenase AspH, which is a target for anticancer therapy.
This research was funded by NIH grant 2R15GM132873-02. We thank Sarah Atkinson (RD, MTU) for her assistance with image preparation.

Anandhu Krisnan, Karabencheva-Christova New Study
Anandhu Krisnan
Ph.D. student
Fathima Hameed Cherilakkudy, Karabencheva-Christova New Study
Fathima Hameed Cherilakkudy
PhD Student
Ann Varghese ’23
Ann Varghese ’23
Ph.D. graduate
Sodiq Waheed ’23
Sodiq Waheed ’23
Ph.D. graduate

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