Chemistry Newsblog

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Notables

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The article by Professor Haiying Liu, Rudy Luck and their research team, entitled “Near-infrared fluorescent probes based on TBET and FRET rhodamine acceptors with different pK(a) values for sensitive ratiometric visualization of pH changes in live cells,” has been selected for inclusion in an online collection highlighting the most popular articles published in Journal of Materials Chemistry B in 2019.

This research has been supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Numbers R15GM114751 and 2R15GM114751-02 (Haiying Liu). 

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Call for Applications: Songer Research Award for Human Health Research

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Matthew Songer, (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA) to support a research project competition for undergraduate and graduate students.

Remembering their own eagerness to engage in research during their undergraduate years, the Songers established these awards to stimulate and encourage opportunities for original research by current Michigan Tech students. The College is extremely grateful for the Songers’ continuing interest in, and support of, Michigan Tech’s programs in human health and medicine.

Any Michigan Tech student interested in exploring a medically related question under the guidance of faculty in the College of Sciences and Arts may apply. Students majoring in any degree program in the college, including both traditional (i.e., biological sciences, kinesiology, chemistry) and nontraditional (i.e., physics, psychology, social science, bioethics, computer science, mathematics) programs related to human health may propose research projects connected to human health. 

Submit applications as a single PDF file to the Office of the College of Sciences and Arts by 4 p.m. Monday, March 30. Applications may be emailed to djhemmer@mtu.edu.

Read more about the Songer Research Award here.

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Be Brief: Glow

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Changes in pH cause the rhodol dyes to glow differently, offering insight into diseases that affect mitophagy. Three slides each with a different color of rhodol dyeFluorescent dyes help scientists see the inner workings of disease. In a new paper by Haiying Liu (Chem), Rudy Luck (Chem) and Thomas Werner (Bio Sci)—along with student researchers—they examine the efficacy of a rhodol-based fluorescent dye.

Diseases like Alzheimer’s and certain kinds of cancers affect the powerhouses of cells — mitochondria. To keep these powerhouses working efficiently, cells remove damaged mitochondria. This process, called mitophagy, is like a cell taking out the trash. In diseased cells, the garbage piles up and the cell’s pH changes. The rhodol dye responds to pH changes and glows brighter.

Luck adds that he considers it a privilege to be able to contribute to Liu’s attempts to find commercially viable probes. The team also acknowledges that the High-Performance Computer system Superior, managed under Director Gowtham, has advanced the research considerably.

Read more about the next steps of this research on the campus research blog Unscripted and celebrate National Chemistry Week with other Unscripted reads about surface chemistry, the science of brewing and mass spectrometry.

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In Print

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Kathryn A. PerrineGraduate students Mikhail Trought (Chemistry) and Chathura de Alwis(Chemistry), with undergraduate student alumnus Isobel Wentworth(ChemEng), research assistant professor Timothy R. Leftwich (MSE), and assistant professor Kathryn A. Perrine (Chemistry) published a paper titled “Influence of surface etching and oxidation on the morphological growth of Al2O3 by ALD” in Surface Science on August 9, 2019.

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In Print

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Graduate students Wafa Mazi, Rashmi Adhiari, Shuai Xia, Mingxi Fang, research scientist Yibin Zhang, research assistant professor Momoko Tajiri, associate professors Rudy L. Luck, Ashutosh Tiwari, Marina Tanasova, and professor Haiying Liu published a paper titled “Fluorescent Probes with High pKa Values Based on Traditional, Near-infrared Rhodamine, and Hemicyanine Fluorophores for Sensitive Detection of Lysosomal pH Variations” in Methods on July 22, 2019.

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New Funding

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Marina TanasovaMarina Tanasova (Chemistry) is Principal Investigator on a project that has received a $446,849 research and development grant from the U.S. Department of Health and Human Services—National Institutes of Health. The project is titled ” Exploiting Cellular Discrimination Through GLUTs With Small-Molecule GLUT-Targeting Probes.” Smitha Rao (Biomed Engineering) is the Co-PI on this potential three-year project.

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New Funding

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Ashutosh Tiwari

Haiying Liu (Chem) is Principal Investigator on a project that has received a $459,000 award (Award Number 2R15GM114751-02) from the National Institute of General Medical Sciences of the National Institutes of Health. This new grant is based on a renewal proposal titled “Ratiometric Near-infrared Fluorescent Probes for Sensitive Detection of Lysosomal and Mitochondrial pH changes in Live Cells.” Ashutosh Tiwari (Chem) is Co-PI in this project.

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Call for Applications: Songer Research Award for Human Health Research

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2018-19 Songer Award Recipients. Pictured Left to Right: Abby Sutherland, Billiane Kenyon, Jeremy Bigalke, Rupsa Basu, Matthew Songer, and Laura Songer.

Matthew Songer, (Biological Sciences ’79) and Laura Songer (Biological Sciences ’80) have generously donated funds to the College of Sciences and Arts (CSA) to support a research project competition for undergraduate and graduate students. Remembering their own eagerness to engage in research during their undergraduate years, the Songers established these awards to stimulate and encourage opportunities for original research by current Michigan Tech students. The College is extremely grateful for the Songers’ continuing interest in, and support of, Michigan Tech’s programs in human health and medicine. This is the second year of the competition.

Students may propose an innovative medically-oriented research project in any area of human health. The best projects will demonstrate the potential to have broad impact on improving human life. This research will be pursued in consultation with faculty members within the College of Sciences and Arts. In the Spring of 2019, the Songer’s gift will support one award for undergraduate research ($4,000) and a second award for graduate research ($6,000). Matching funds from the College may allow two additional awards.

Any Michigan Tech student interested in exploring a medically related question under the guidance of faculty in the College of Sciences and Arts may apply. Students majoring in any degree program in the college, including both traditional (i.e., biological sciences, kinesiology, chemistry) and nontraditional (i.e., physics, psychology, social science, bioethics, computer science, mathematics) programs related to human health may propose research projects connected to human health. Students are encouraged to propose original, stand-alone projects with expected durations of 6 – 12 months. The committee also encourages applications from CSA students who seek to continue research projects initiated through other campus mechanisms, such as the Summer Undergraduate Research Fellowship (SURF) program, Pavlis Honors College activities or the Graduate Research Forum (GRF).

Funds from a Songer Award may be used to purchase or acquire research materials and equipment needed to perform the proposed research project. Access to and research time utilizing University core research facilities, including computing, may be supported. Requests to acquire a personal computer will be scrutinized and must be fully justified. Page charges for publications also may be covered with award funds, as will travel to appropriate academic meetings. This award may not be used for salary or compensation for the student or consulting faculty.

To apply:

  • Students should prepare a research project statement (up to five pages in length) that describes the background, methods to be used, and research objectives. The statement also should provide a detailed description of the experiments planned and expected outcomes. Students must indicate where they will carry out their project and attach a separate list of references/citations to relevant scientific literature.
  • The application package also should provide a concise title and brief summary (1 page) written for lay audiences.
  • A separate budget page should indicate how funds will be used.
  • A short letter from a consulting faculty member must verify that the student defined an original project and was the primary author of the proposal. The faculty member should also confirm her/his willingness to oversee the project. This faculty letter is not intended to serve as a recommendation on behalf of the student’s project.

Submit applications as a single PDF file to the Office of the College of Sciences and Arts by 4:00 p.m. Monday, April 22. Applications may be emailed to djhemmer@mtu.edu.

The selection committee will consist of Matthew Songer, Laura Songer, Shekhar Joshi (BioSci) and Megan Frost (KIP). The committee will review undergraduate and graduate proposals separately and will seek additional comments about the proposed research on an ad-hoc basis from reviewers familiar with the topic of the research proposal. Primary review criteria will be the originality and potential impact of the proposed study, as well as its feasibility and appropriateness for Michigan Tech’s facilities.

The committee expects to announce the recipients by early May of 2019. This one-time research award will be administered by the faculty advisor of the successful student investigator. Students will be expected to secure any necessary IRB approval before funds will be released. Funds must be expended by the end of spring semester 2020; extensions will not be granted. Recipients must submit a detailed report to the selection committee, including a description of results and an accounting of finds utilized, no later than June 30, 2020.

Any questions may be directed to Megan Frost (mcfrost@mtu.edu), David Hemmer (djhemmer@mtu.edu) or Shekhar Joshi (cpjoshi@mtu.edu).

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