Author: Heather Powers

Chemistry Students present at Undergrad Research Symposium

imedImageThe Undergraduate Research Symposium highlights the amazing cutting-edge research being conducted on Michigan Tech’s campus by some of our best and brightest undergraduate students.

The students showcasing their work today have spent a significant portion of the past year working alongside Michigan Tech faculty and graduate students to explore, discover and create new knowledge. They’ve spent long hours in the lab or out in the field designing experiments, gathering data, creating new models and testing hypotheses. They’ve applied their classroom knowledge in new and sometimes unexpected ways, and developed new skills that will propel them forward in their careers.

Alexis Ferrier

Title: Synthesis of a Fructopyranose Mimic as a Carbohydrate Probe for Fructose Transporters
Advisor: Dr. Marina Tanasova
Overview: Ferrier’s goal is to synthesize stable fructopyranose mimics as tools to distinguish cancer from normal cells on the basis of fructose uptake efficiency.

Emily Lilla

Title: Sulfenamide Form of Omeprazole in Interaction with the Primary Amino Acid Sites of H+/K+ ATPase as Investigated at Electronic Structure Level
Advisor: Dr. Loredana Valenzano
Overview: Lilla looked at the drug Omeprazole (Prilosec®), which is the first medication that treats Acid Reflux, and serves as proton pump inhibitors (PPI). It inhibits the enzymes CYP2C19 and CYP3A4, and prevents the final step of acid production and basal and stimulated acid secretion. Lilla used Density Functional Theory (DFT) to determine the equilibrium geometries for each molecule using different levels of theory.

Randall Wilharm

Title: Synthesis and Characterizaion of Novel Photoactive Lanthanide Complexes
Advisor: Dr. Rudy Luck
Overview: Wilharm’s goal was to use the unique photochemical properties of three lanthanide metals, sarmarium, europium, and terbuim, with a novel photoactive ligand to create a new catalyst that harnesses light to push reactions.

New Funding – Xiaohu Xia wins CAREER Award

image113518-persThere is something very noble about Xiaohu Xia’s research. He wants to use palladium, platinum, ruthenium and other corrosion-resistant metals to refine tests to detect biomarkers for cancer and infectious diseases. To do so, he plans to use nanostructures made of these noble metals that mimic natural enzymes and has earned a CAREER Award from the National Science Foundation (NSF) to focus on this research.

The grant covers five years, totaling $457,783, and enables Xia to dig deep into the structure-property relationships of the bimetallic peroxidase mimics at the atomic level. Even small changes in nanostructures can produce big results, demonstrated by his lab with improvements in the catalytic efficiencies of iridium-coated palladium and ruthenium nanostructures.

Read the full story on the Michigan Tech news website.

On the Road

image67731-persLoredana Valenzano (Chem) recently participated in the GIAN program of the Government of India as a co-organizer with Ravindra Pandey (Chem).

Valenzano gave a series of lectures on modeling of materials to graduate students and faculty members at the workshop. She introduced state-of-the-art computational modeling methods to the next generation of students in chemistry, physics and materials science. The workshop was organized by Guru Jambeshwar University of Science and Technology at HIsar, Harayana, India.

Michigan Tech has a large presence in the GIAN program — Amitabh Narain (MEEM), Chandrashekhar Joshi (Bio) and S. Komar Kawatra (ChE) have also participated in the program activities in India.

Climate Discussion Tonight

During the Nov. 3, 2016, Climate Café event, Robert Handler of Michigan Tech’s Sustainable Futures Institute discusses energy efficiency and ways to mitigate climate change. (Video by Keweenaw Now)

The fourth in a series of discussions on climate change will take place from 6 to 8 p.m. tonight at the Orpheum/Studio Pizza in Hancock.

The purpose of this fourth event in the series is to continue the discussions about what activities and topics we should focus on as a local community when we think about climate change impacts and our responses to those impacts.

There are lots of potential strategies to mitigate or adapt to the impacts of climate change, and we want to gather a community of interested people who will help plan the future priorities for our grassroots organization. We will have a few five minute presentations from local people who are developing responses to climate change, and then we will break into groups according  to your interests, and start making plans.

The series is organized by the Keweenaw Climate Community, sponsored by the local chapter of the American Chemical Society and the Department of Social Sciences at Michigan Tech.

More can be found out by reading this story in Keweenaw Now.

New PHI 5800 XPS for Surface Analysis

PHI-5800-XPS-6The Applied Chemical and Morphological Analysis Laboratory (ACMAL) on campus received a new PHI 5800 X-ray photoelectron spectrometer (XPS). The PHI5800 XPS is equipped with dual source anode (Al and Mg), a hemispherical analyzer, for XPS and AES analysis, including elemental mapping capabilities, an electron gun source for AED analysis, an ion sputter gun for depth profiling, a heatable sample stage, and stage tilting for angle-resolved XPS.

The XPS was generously donated by the Army Research Laboratories with the help from the Department of Chemistry. The new XPS will help ACMAL and chemistry students greatly expand their research.

The Applied Chemical and Morphological Analysis Laboratory is a Michigan Tech University Core Facility which is part of the Materials Characterization & Fabrication Facilities.

New Glycobiology Study led by Tarun Dam

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Tarun Dam led a new study, published this week in Biochemistryexamining the biomechanics of galectin-3’s interaction with glycosaminoglycans (GAG) and proteoglycans. His team includes graduate students Melanie Talaga, Ni Fan, Ashli Fueri, Robert Brown and Research Assistant Professor Purnima Bandyopadhyay.

At the Laboratory of Mechanistic Glycobiology, Dam and his students study the sugar, including glucose and other structural, complex sugars, that fuel our bodies. GAGs assist in controlling growth factor proteins, which go unchecked as cancerous tumors grow.

Even though the findings of the study were unexpected, it opens up new possibilities for understanding glycobiology and biomechanics. “Seeing galectin-3 interact with GAGs and proteoglycans is like finding a rose in the petunias—it’s very unexpected,” Dam says. “It’s fair to say that this requires revisiting the reported biological functions of GAGs, proteoglycans and galectin-3.”

Next, Dam and his team look into additional research, “Now we have to reconsider the whole drama, retracing the steps and actions of that character… we are using cell lines and animal models to study this interaction in a cellular context.”

Read more on Michigan Tech News, by Allison Mills.