Category: Research

Graduate students Mingxi Fang, Rashmi Adhikari, Jianheng Bi, Wafa Mazi, Nethaniah  Dorh, visiting scholar Jianbo Wang, undergraduate  Conner Nathan, research associate professor Tayana Karabencheva-Christova, associate professor Ashutosh Tiwari , and professor Haiying Liu published a paper entitled “Fluorescent probes for sensitive and selective detection of pH changes in live cells in visible and near-infrared channels” in the Journal of Chemistry Materials.

Shiyue Fang is the principal investigator on a project that has received a $426,748 research and development grant from the US Dept. of Health and Human Services, National Institutes of Health.

The project is titled “Synthesis of Base-Labile and Electrophophilic Oligodeoxynucleotides.”

This is a three-year project.

Shiyue Fang (Principal Investigator), Tarun Dam, Xiaohu Xia, and Kathryn Perrine (Co-PIs) received new funding for their project, “MRI: Acquisition of an Atomic Force Microscope for Force Measurement, Single-Molecule Manipulation, and other Applications.”

This is a three-year project.

The Undergraduate Research Symposium highlights the amazing cutting-edge research being conducted on Michigan Tech’s campus by some of our best and brightest undergraduate students.

The students showcasing their work today have spent a significant portion of the past year working alongside Michigan Tech faculty and graduate students to explore, discover and create new knowledge. They’ve spent long hours in the lab or out in the field designing experiments, gathering data, creating new models and testing hypotheses. They’ve applied their classroom knowledge in new and sometimes unexpected ways, and developed new skills that will propel them forward in their careers.

Alexis Ferrier

Title: Synthesis of a Fructopyranose Mimic as a Carbohydrate Probe for Fructose Transporters
Advisor: Dr. Marina Tanasova
Overview: Ferrier’s goal is to synthesize stable fructopyranose mimics as tools to distinguish cancer from normal cells on the basis of fructose uptake efficiency.

Emily Lilla

Title: Sulfenamide Form of Omeprazole in Interaction with the Primary Amino Acid Sites of H+/K+ ATPase as Investigated at Electronic Structure Level
Advisor: Dr. Loredana Valenzano
Overview: Lilla looked at the drug Omeprazole (Prilosec®), which is the first medication that treats Acid Reflux, and serves as proton pump inhibitors (PPI). It inhibits the enzymes CYP2C19 and CYP3A4, and prevents the final step of acid production and basal and stimulated acid secretion. Lilla used Density Functional Theory (DFT) to determine the equilibrium geometries for each molecule using different levels of theory.

Randall Wilharm

Title: Synthesis and Characterizaion of Novel Photoactive Lanthanide Complexes
Advisor: Dr. Rudy Luck
Overview: Wilharm’s goal was to use the unique photochemical properties of three lanthanide metals, sarmarium, europium, and terbuim, with a novel photoactive ligand to create a new catalyst that harnesses light to push reactions.

Loredana Valenzano (Chem) recently participated in the GIAN program of the Government of India as a co-organizer with Ravindra Pandey (Chem).

Valenzano gave a series of lectures on modeling of materials to graduate students and faculty members at the workshop. She introduced state-of-the-art computational modeling methods to the next generation of students in chemistry, physics and materials science. The workshop was organized by Guru Jambeshwar University of Science and Technology at HIsar, Harayana, India.

Michigan Tech has a large presence in the GIAN program — Amitabh Narain (MEEM), Chandrashekhar Joshi (Bio) and S. Komar Kawatra (ChE) have also participated in the program activities in India.