Category Archives: Research

New Funding

ShiyueFang20140117_0001Shiyue Fang is the principal investigator on a project that has received a $426,748 research and development grant from the US Dept. of Health and Human Services, National Institutes of Health.

The project is titled “Synthesis of Base-Labile and Electrophophilic Oligodeoxynucleotides.”

This is a three-year project.





In Print

136701_webHaiying Liu (Chem), Ashutosh Tiwari (Chem), Ranjit Pati (Physics), along with graduate students Rashmi Adhikari, Mingxi Fang, Nethaniah Dorh, Cong Li, Jingtuo Zhang and Meghath Jaishi, published a paper titled “Near-Infrared Fluorescent Probes with Large Stokes Shifts for Sensing Zn(II) Ions in Living Cells” in ACS Sensors.

Their research in using fluorescent probes to find cancer cells was covered by Michigan Tech News, Phys.org, eCancer, Science Daily, Health Medicine Network, R&D Magazine and many other publications worldwide.

Science360, a science news website published by the National Science Foundation (NSF), spotlighted the fluorescent probe research of Liu as one of its headline stories on March 30.

 


Chemistry Students present at Undergrad Research Symposium

imedImageThe Undergraduate Research Symposium highlights the amazing cutting-edge research being conducted on Michigan Tech’s campus by some of our best and brightest undergraduate students.

The students showcasing their work today have spent a significant portion of the past year working alongside Michigan Tech faculty and graduate students to explore, discover and create new knowledge. They’ve spent long hours in the lab or out in the field designing experiments, gathering data, creating new models and testing hypotheses. They’ve applied their classroom knowledge in new and sometimes unexpected ways, and developed new skills that will propel them forward in their careers.

Alexis Ferrier

Title: Synthesis of a Fructopyranose Mimic as a Carbohydrate Probe for Fructose Transporters
Advisor: Dr. Marina Tanasova
Overview: Ferrier’s goal is to synthesize stable fructopyranose mimics as tools to distinguish cancer from normal cells on the basis of fructose uptake efficiency.

Emily Lilla

Title: Sulfenamide Form of Omeprazole in Interaction with the Primary Amino Acid Sites of H+/K+ ATPase as Investigated at Electronic Structure Level
Advisor: Dr. Loredana Valenzano
Overview: Lilla looked at the drug Omeprazole (Prilosec®), which is the first medication that treats Acid Reflux, and serves as proton pump inhibitors (PPI). It inhibits the enzymes CYP2C19 and CYP3A4, and prevents the final step of acid production and basal and stimulated acid secretion. Lilla used Density Functional Theory (DFT) to determine the equilibrium geometries for each molecule using different levels of theory.

Randall Wilharm

Title: Synthesis and Characterizaion of Novel Photoactive Lanthanide Complexes
Advisor: Dr. Rudy Luck
Overview: Wilharm’s goal was to use the unique photochemical properties of three lanthanide metals, sarmarium, europium, and terbuim, with a novel photoactive ligand to create a new catalyst that harnesses light to push reactions.



New Funding – Xiaohu Xia wins CAREER Award

image113518-persThere is something very noble about Xiaohu Xia’s research. He wants to use palladium, platinum, ruthenium and other corrosion-resistant metals to refine tests to detect biomarkers for cancer and infectious diseases. To do so, he plans to use nanostructures made of these noble metals that mimic natural enzymes and has earned a CAREER Award from the National Science Foundation (NSF) to focus on this research.

The grant covers five years, totaling $457,783, and enables Xia to dig deep into the structure-property relationships of the bimetallic peroxidase mimics at the atomic level. Even small changes in nanostructures can produce big results, demonstrated by his lab with improvements in the catalytic efficiencies of iridium-coated palladium and ruthenium nanostructures.

Read the full story on the Michigan Tech news website.


On the Road

image67731-persLoredana Valenzano (Chem) recently participated in the GIAN program of the Government of India as a co-organizer with Ravindra Pandey (Chem).

Valenzano gave a series of lectures on modeling of materials to graduate students and faculty members at the workshop. She introduced state-of-the-art computational modeling methods to the next generation of students in chemistry, physics and materials science. The workshop was organized by Guru Jambeshwar University of Science and Technology at HIsar, Harayana, India.

Michigan Tech has a large presence in the GIAN program — Amitabh Narain (MEEM), Chandrashekhar Joshi (Bio) and S. Komar Kawatra (ChE) have also participated in the program activities in India.