Robert Larson, PhD student in Biological Sciences, has been awarded the 2016 AAS-Lundbeck Research Fellowship as announced on their website. His research is titled ” Targeting Cardiac Sympathetic and Renin Angiotensin Systems with Ang-(1-7) in Hypertrophic Cardiomyopathy” which will be completed in the Department of Internal Medicine at The University of Iowa Carver College of Medicine with Dr. Mark Chapleau.
The Summary of his research:
Hypertrophic cardiomyopathy (HCM) is a relatively common inherited disease characterized by cardiac hypertrophy (enlarged heart), fibrosis, and dysfunction. Patients with HCM exhibit abnormal neural reflex control of blood pressure and heart rate, and are at high risk of developing heart failure, arrhythmias and sudden cardiac death. Current treatment strategies primarily target symptoms and not development of the disease. We propose a novel treatment strategy with Angiotensin-(1-7), a peptide known to diminish sympathetic nerve activity and the pro-fibrotic and pro-hypertrophic actions of angiotensin II. We hypothesize that a combination of sustained inhibition of cardiac sympathetic activity and inhibition of adverse cardiac actions of angiotensin II will act synergistically to prevent or reverse cardiac fibrosis, hypertrophy and arrhythmias in HCM. We will test this hypothesis using an established mouse model of HCM, in which a human mutation is targeted selectively to the heart.
Robert will be completing his degree under Kineseology and Integrative Physiology Adjunct Professor Qing-Hui Chen this summer.
Congratulations from Biological Sciences!