Dr. Zhiying Shan (KIP) is the principal investigator (PI), and Dr. Qinghui Chen (KIP) is the Co-PI on a R01 project that has received $1.665,903 from the National Institutes of Health.
This four-year project is titled “Contribution of Orexin System to Hypertension.”
Orexins are neuropeptides secreted from the hypothalamus. They bind their receptors and participate in regulating multiple physiological functions in healthy and pathological conditions. Orexin receptors’ expression is observed to be increased in the brain cardiovascular relevant regions of hypertensive animal models. The objective of this project is to investigate whether increased brain orexin system results in hypertension, and whether blockage of orexin signaling prevents the development of hypertension. This study has potential to identify new therapeutic targets for hypertension treatment.