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Biofluids Lab News (@hatoum_hoda)

**We had a blast at #TCT2022!  Brennan Vogl and Alireza Asadbeygi presented their work on left atrial appendage occlusion DRT and coronary aneurysms thrombosis risk assessment, respectively. We had the chance to meet our collaborators (face to face for the 1st time and after a while!) and attend plenty of talks, live cases and clinical trials results. **

**Our paper titled “Predicting hemodynamic indices in coronary artery aneurysms using response surface method: An application in Kawasaki disease” where we developed regression models can be used to ultimately assess the thrombotic risk of coronary artery aneurysm cases from the hemodynamic perspective is now published in Computer Methods and Programs in Biomedicine Journal! Congratulations to PhD student Alireza Asadbeygi on his first publication! Link to paper is here: https://www.sciencedirect.com/science/article/pii/S0169260722003893?dgcid=author**

**Dr. Hatoum presented was invited to present a talk titled “Predicting Outcomes After Transcatheter Aortic Valve Replacement” in the World Congress of Biomechanics (WCB) 2022**

**Huge congratulations to PhD students Brennan Vogl and Alireza Asadbeygi for being awarded the Blue Cross Blue Shield of Michigan Foundation student awards! Excited for them to keep the great work! https://www.bcbsm.com/content/dam/microsites/foundation/Documents/bcbsm-foundation-2022-grant-highlights.pdf **

**PhD students Brennan Vogl and Alireza Asadbeygi attended SB3C 2022 in Maryland and presented their work.

Alireza presented his work “Predicting Hemodynamic Indices in Coronary Artery Aneurysms Using Response Surface Method: An Application in Kawasaki Disease” in the PhD-Level Student Paper Competition Session 1: Biofluid Mechanics and Cardiovascular Imaging.

Brennan Vogl presented: (1) Predicting Valve Performance Using Logistic Regression in the Special Session in Honor of Dr. Ajit Yoganathan and (2) Effect of Aortic Curvature on Bioprosthetic Aortic Valve Performance in the Device and Treatment Implications session.

Dr. Hatoum had a presentation on “Flow Dynamic Differences Between Self-Expanding and Balloon Expandable Transcatheter Aortic Valves” in Dr. Yoganathan’s special session.

Brennan Vogl also presented 2 posters: (1) Flow Dynamics Assessment in a Physiological Aortic Arch Using a Validated Computational Framework and (2) Left Atrial Hemodynamics after Catheter Ablation.

Photo credits: Shelley Chee-Mei Gooden**

**Congratulations to PhD student Brennan Vogl on being awarded the DeVlieg Foundation Fellowship 2022! The Graduate Dean Awards Advisory Panel and dean were impressed with Brennan’s research, publication record, and contribution to the mission of Michigan Tech.

Link: https://blogs.mtu.edu/gradschool/2022/05/23/devlieg-graduate-summer-2022-research-recipient-brennan-vogl/**

**Our paper “Comparison of Catheterization Versus Echocardiographic Based Gradients in Balloon Expandable Versus Self Expanding Transcatheter Aortic Valve Implantation” by Michael Biersmith, Nader Makki, Hoda Hatoum et al. is now published in The Journal of Invasive Cardiology. The link to the paper can be found here: https://www.hmpgloballearningnetwork.com/site/jic/comparison-catheterization-versus-echocardiographic-based-gradients-balloon-expandable**

**Our paper “A Preliminary Study on the Usage of a Data-Driven Probabilistic Approach to Predict Valve Performance Under Different Physiological Conditions” by Vogl et al. where we present a data driven statistical model that can estimate the probability of a valve not meeting the “safe” pressure gradient (≤ 20 mmHg) under certain physiological conditions using logistic regression is now published in the Annals of Biomedical Engineering (ABME). The link to the paper can be found here: https://link.springer.com/article/10.1007/s10439-022-02971-8**

**Our paper titled “Controlling the Flow Separation in Heart Valves Using Vortex Generators” where we numerically investigated the impact of various Vortex Generators (VG) configurations on a Bileaflet Mechanical Heart Valve (BMHV) to elucidate the underlying flow physics for further understanding of blood damage is now published in the Annals of Biomedical Engineering (ABME). The link to the paper can be found here: https://link.springer.com/article/10.1007/s10439-022-02966-5**

**Our paper titled “Effects of MitraClip Therapy on Mitral Flow Patterns and Vortex Formation: An In Vitro Study” where we assessed the diastolic hemodynamic differences in the flow field in the vicinity of the valve post-MitraClip repair is now published in the Annals of Biomedical Engineering (ABME). The link to the paper can be found here: https://link.springer.com/article/10.1007/s10439-022-02944-x**

**Congratulations to undergraduate student Nick Niemi for starting as a junior biomedical engineer intern at DASI Simulations in Dublin, Ohio! **

**Congratulations to PhD student Brennan Vogl on being awarded the PhD graduate Research Excellence Award and undergraduate student Nick Niemi on the Michael R Neuman Award! So proud of their great contributions to research!**

**Congratulations to PhD student Brennan Vogl on winning the 2nd place for poster presentations at the Graduate Research Colloquium Presentations**

**Our paper titled “Effect of catheter ablation on the hemodynamics of the left atrium” where we explored how patient history, flow dynamics and geometry can help identify the population that is best suited for atrial fibrillation ablation is now published in the Journal of Interventional Cardiac Electrophysiology! Congratulations to PhD student Brennan Vogl on another great study. Link to paper is here: https://link.springer.com/article/10.1007/s10840-022-01191-3**

**PhD student Brennan Vogl had an oral presentation at Heart Valve Society (HVS 2022, Miami, FL) titled “Impact Of Blood Pressure Conditions On Coronary Perfusion And Hemodynamics After Aortic Valve Replacement”.

**Dr. Hatoum had an invited talk at Heart Valve Society (HVS 2022) titled “Future Valve Designs to Mitigate Valve Thrombosis”.

**Congratulations to PhD student Alireza Asadbeygi on being a finalist for 2022 ASME-BED/SB3C Student Paper Competition PhD-level! Alireza will present his work as an oral presentation in Maryland in June 2022**.

Take a tour in the Biofluids Lab and get to know what we do! Check the link below:

Play Biomedical Engineering at MTU Gets to the Heart of the Matter video
Preview image for Biomedical Engineering at MTU Gets to the Heart of the Matter video

Biomedical Engineering at MTU Gets to the Heart of the Matter

Dr. Hatoum and Brennan were hosts on Valentine’s Day’s Husky Bites. You can check the recording of the session and the blog under the links below:

Play How Can You Mend a Broken Heart? Flow Dynamics in Arrhythmias video
Preview image for How Can You Mend a Broken Heart? Flow Dynamics in Arrhythmias video

How Can You Mend a Broken Heart? Flow Dynamics in Arrhythmias

**Congratulation to PhD student Brennan Vogl on being awarded 2 travel awards from GSG and HRI to present his work on blood pressure influence after aortic valve replacement on coronary perfusion at the Heart Valve Society (HVS 2022) conference!

**Our paper “Flow dynamics in the sinus and downstream of third and fourth generation balloon expandable transcatheter aortic valves” is now published in the Journal of Mechanical Behavior of Biomedical Materials (JMBBM). Congratulations to PhD student Brennan Vogl! Link to the paper is here: https://doi.org/10.1016/j.jmbbm.2022.105092

**Our paper “Impact of blood pressure on coronary perfusion and valvular hemodynamics after aortic valve replacement” is now published in Catheterization and Cardiovascular Interventions (CCI) Journal. Congratulations to PhD student, Brennan Vogl, on his second first-authored paper this year! Link to the paper is here: https://onlinelibrary.wiley.com/doi/10.1002/ccd.30052

**Dr. Hatoum was awarded a Research Excellence Fund (REF) research seed proposal to study hemodynamic factors associated with thromboembolic risk in Kawasaki Disease.

**Our paper “Predictive Model for Thrombus Formation After Transcatheter Valve Replacement” is now published in Cardiovascular Engineering and Technology (CVET).

https://www.sciencedirect.com/science/article/pii/S193687982101757X?dgcid=author

**Congratulations to Brennan Vogl for his first first-authored publication “Impact of calcific aortic valve disease on valve mechanics” in the Biomechanics and Modeling in Mechanobiology (BMMB) journal.

https://link.springer.com/article/10.1007/s10237-021-01527-4

**Our paper “Neosinus and Sinus Flow After Self-Expanding and Balloon-Expandable Transcatheter Aortic Valve Replacement” is now published in JACC: Cardiovascular Interventions journal.

https://www.sciencedirect.com/science/article/pii/S193687982101757X?dgcid=author

**PhD student Brennan Vogl had an oral presentation on “Hemodynamic Assessment Of The New Generation Balloon Expandable Transcatheter Aortic Valve” at BMES 2021.

**PhD student Brennan Vogl had a poster presentation that aims at “Evaluating the impact of ablation on atrial hemodynamics” at BMES 2021.

**PhD student Brennan Vogl and undergraduate student Nick Niemi had a poster presentation on “Effect Of Blood Transfusions On Silent Cerebral Infarctions In Sickle Cell Disease Patients” at BMES 2021.

**Dr. Hatoum had an oral presentation on “Neo-Sinus and Sinus Flows After Transcatheter Aortic Valve Implantation of Evolut, SAPIEN 3, Acurate Neo, and Allegra” at SB3C 2021.

**Brennan Vogl presented his work on the “Effect of Blood Pressure Conditions on Transcatheter Aortic Valve Performance and Coronary Flow” at SB3C 2021.

**Dr. Hatoum received an honorable mention at the American College of Cardiology (ACC 2021) Young Investigator Awards: Basic and Translational Science. The talk was on a novel thrombosis predictive model after transcatheter aortic valve replacement.

**Dr. Hatoum was awarded the Summer of Biomechanics, Bioengineering and Biotransport (SB3C) 2021 Diversity Participation Award. This award has been funded by the Georgia Tech Parker H Petit Institute for Bioengineering and Biosciences.

**Nick Niemi was awarded a SURF award to continue working on a novel transcatheter mitral valve device. Congratulations Nick! https://www.mtu.edu/research/about/awards/surf/

Hoda Hatoum Trainees

Current Trainees

Graduate Students

Brennan Vogl

Brennan Vogl
PhD Student in Biomedical Engineering
BS in Biomedical Engineering from Michigan Tech
Email: bjvogl@mtu.edu
Brennan is currently working on atrial, ventricular, and valvular flow assessment and congenital heart defects flow studies. Brennan’s work is experimental and computational. In his free time, Brennan enjoys cooking and downhill skiing.

Alireza Asadbeygi

PhD Student in Biomedical Engineering
BS in Mechanical Engineering from K.N. Toosi University
Email: aasadbey@mtu.edu
Alireza is interested in numerical and experimental investigations in the cardiovascular system.
He is currently doing research in developing computational and experimental tools for KAWASAKI disease. He enjoys swimming and running in his free time.

Undergraduate Students

Nick Niemi

Nick Niemi
BS Student in Biomedical Engineering
Email: nniemi@mtu.edu
Nick is currently working on designing a novel transcatheter mitral valve device. In his free time, he enjoys skiing, biking, fishing, and hunting. Nick is a member of the Track/XC teams.

Past Trainees

Shivam Tiwari

Shivam Tiwari
MS Student in Mechanical Engineering
BS in Mechanical Engineering
Email: shivamti@mtu.edu
Shivam worked on CFD and finite element simulations of cerebral vessels for sickle cell disease. In his free time, Shivam enjoys painting, singing, CAD modeling, performing simulations, and sketching.

Rajat Ratnakar Gadhave

Rajat Ratnakar Gadhave
MS student in the Mechanical Engineering and Engineering Mechanics department

Email: rgadhave@mtu.edu
Rajat was a graduate student who worked in the biofluids lab from Fall 2020 – Fall 2021. Rajat assisted in the design and manufacturing of a whole left heart model with a pulse duplicator testing system. Rajat also worked on projects involving in-vitro characterizations of surgical aortic valve and transcatheter aortic valve performance. Moreover, Rajat worked on creating patient-specific models from computed tomography scans. In his free time, Rajat enjoys exploring.

Alex MacLean

Alex MacLean
BS Student in Biomedical Engineering
Email: abmaclea@mtu.edu
Alex worked on Finite Element Analysis as part of designing a novel transcatheter mitral valve device. In his free time, Alex enjoys snow skiing, snowmobiling, and hiking.


Hoda Hatoum Profile