Category: News

Diabetic Wound Repair Project Funding for Bruce Lee

Bruce Lee
Bruce Lee

Bruce Lee (BioMed) is the principal investigator on a project that has received a $434,993 research and development grant from the National Institutes of Health.

The project is entitled, “Multifunctional Nanocomposite Bioadhesive for Diabetic Wound Repair.” Xiaoqing Tang (BioSci) and Rupak Rajachar (BioMed) are Co-PI’s on this potential three-year project.

Lee is also the principal investigator on a project that has received a $102,779 research and development from the Office of Naval Research. The project is entitled, “Electro-Responsive Underwater Adhesive Based on Mussel Adhesive Chemistry.”

This is a potential three-year project totaling $524,995.

By Sponsored Programs.


Researchers Attend Annual Meeting of the Adhesion Society

Adhesion Society Meeting Graphic

Rupak Rajachar (BioMed), Bruce Lee (BioMed), Ariana Tyo (BioMed) and Saleh Akram Bhuiyan (BioMed) attended the 43rd Annual Meeting of the Adhesion Society in Charleston, South Carolina.

Rajachar chaired a session entitled “Biomedical Adhesion.” Lee gave an oral presentation entitled “Tuning the ROS Release from Catechol-containing Bioadhesive.”

Tyo gave an oral presentation entitled “Adhesive Antimicrobial Polydopamine Surface Coatings to Prevent Biofilm Formation on Stainless Steel.” The content of this talk was recently published in Frontiers in Chemistry.

Bhuiyan was a finalist for the Peebles Award for Graduate Student Research in Adhesion Science and gave an oral presentation entitled “In Situ Deactivation of Catechol-Containing Adhesive using Electrochemistry.” The content of this talk was recently published in the Journal of the American Chemical Society and was highlighted in the Michigan Tech News.

The meeting was February 23-26, 2020.


Bruce Lee Publishes a Study of a Multifunctional Microgel

ACS Applied Materials and Interfaces cover.

Bruce Lee (BioMed) published a paper titled “Iron Magnetic Nanoparticle-Induced ROS Generation from Catechol-Containing Microgel for Environmental and Biomedical Applications” in ACS Applied Materials & Interfaces.

The coauthors are graduate student Zhongtian Zhang (BioMed), undergraduate student Max Reaume (BioMed), postdoctoral researcher Bo Liu (BioMed) and collaborators Chao Zhou and Min Wu from Changzhou University and Guangdong University of Technology, respectively.

https://doi.org/10.1021/acsami.9b19726

This article is part of the Advances in Biocidal Materials and Interfaces special issue.

Extract

Reactive oxygen species (ROS) can degrade organic compounds and function as a broad-spectrum disinfectant. Here, dopamine methacrylamide (DMA) was used to prepare catechol-containing microgels, which can release ROS via metal-catechol interaction. A combination of the microgel and iron magnetic nanoparticle (FeMNP) significantly reduced the concentration of four organic dyes (Alizarin Red S, Rhodamine B, Crystal Violet, and Malachite Green) and an antibiotic drug, ciprofloxacin, dissolved in solution.

Additionally, catechol chelates heavy metal ions, resulting in their removal from solution and repurposed these metal ions for dye degradation.

This multifunctional microgel can potentially be used for environmental applications for the removal of organic pollutants and heavy metal ions from wastewater, as well as reducing bacterial infection in biomedical applications.


Bruce Lee Publishes in Chemical Society Reviews

Bruce Lee (BioMed) published a review article in Chemical Society Reviews entitled “Catechol-functionalized hydrogels: biomimetic design, adhesion mechanism, and biomedical applications.”

Chemical Society Reviews is the Royal Society of Chemistry’s leading reviews journal and publishes high-impact articles at the forefront of the chemical sciences. (Impact Factor: 40.443)

https://doi.org/10.1039/C9CS00285E

This review compiles state-of-the-art examples and details progress in the design and development of adhesive hydrogel materials based on mussel-inspired catechol chemistry. From a fundamental perspective, two main aspects have been examined: the role of water in undermining adhesion in hydrogels and the adhesive mechanism involving catechol-containing adhesives and coatings.

Read more…

Lindsay Sandell Named a University Innovation Fellow

Lindsay Sandell
Lindsay Sandell

Congratulations to Abigail Kuehne (Psychology and Communication, Culture, and Media/ Applied Cognitive Science and Human Factors ’21), Sam Raber (Psychology ’22), Lindsay Sandell (Biomedical Engineering ’21), and Gary Tropp (Computer Network and System Administration ’22), who have been named University Innovation Fellows by Stanford University’s Hasso Plattner Institute of Design (d.school).

Read more and watch the video at the Pavlis Honors College blog.


HHS-NIH Funding for Sangyoon Han

Sangyoon Han
Sangyoon Han

Sangyoon Han (BioMed) is the principal investigator on a project that has received a $414,802 research and development grant from the U.S. Department of Health and Human Services National Institutes of Health.

The project is entitled, “Nascent Adhesion-Based Mechano-Transmission for Extracellular Matrix Stiffness Sensing.”

This is a potential three-year project.

By Sponsored Programs.


A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces

Interaction of neuronal cells with MEA shank.
Interaction of neuronal cells with MEA shank.

Given mankind’s limited ability to treat damage to the human nervous system, neural interface systems (NISs) have emerged as an attractive alternative to conventional therapies. For a NIS to work, a microelectrode array (MEA) must be surgically implanted into the brain to allow an external computer to read and interpret neuronal signals for various applications. Dr. Zhao’s Lab has recently published a review paper titled “A Critical Review of Microelectrode Arrays and Strategies for Improving Neural Interfaces” in Advanced Healthcare Materials.
https://doi.org/10.1002/adhm.201900558

This review article, authored by Morgan Ferguson (MS student), Dhavan Sharma (PhD candidate), David Ross (former MS student), and Dr. Feng Zhao, provides critical insight into the recent advances in strategies for improving NIS microelectrode array biocompatibility and neural interfacing capabilities, including alterations in microelectrode array surface properties (both surface chemistry and topography), surface geometry, and stiffness. Individually, each strategy provides varying degrees of success in altering microelectrode array biocompatibility, electrical conductivity, signal maintenance, and/or overall longevity along with the severity of foreign body response. By using a multiprong design for MEAs (one combining modifications to the surface, geometry, and hardness into one MEA) instead of using a lone modification, it could allow NISs to operate for a much longer period.


Invited Review of Scaffold Materials for Cardiac Tissue Engineering

Illustrations of of several kinds of scaffolds
Figure: Scaffold fabrication strategies for cardiac patch engineering

Cardiovascular diseases are the major causes of death worldwide. As a part of their ongoing project to construct a tissue engineered cardiac patch to repair damaged heart muscle, Dr. Zhao’s Lab team has recently reviewed contemporary techniques to fabricate heart-specific matrices for cardiac patch engineering. This invited review titled “Constructing biomimetic cardiac tissues: a review of scaffold materials for engineering cardiac patches” was published by Dhavan Sharma (PhD candidate), Morgan Ferguson (MS student), Dr. Timothy J. Kamp (collaborator at University of Wisconsin Madison), and Dr. Feng Zhao in Emergent Materials, Springer. (https://doi.org/10.1007/s42247-019-00046-4)

Engineered tissues are composed of two major components: cells and the extracellular matrix. This review focuses on the latter one, which holds the cells in a 3D space. Recent advances in scaffold fabrication techniques have enabled scientists to a generate heart-specific microenvironment within the engineered tissue constructs. These cardiac-specific scaffolds can be developed using synthetic polymers or native tissues as well as cell sheets. This article will provide readers with a timely review about different fabrication methods that have been employed to develop scaffold materials which ultimately have been used to engineer cardiac patches.


BME Represented at the Gordon Research Conference on the Science of Adhesion

Mount HolyokeBruce Lee (BioMed), Rattapol Pinnaratip, and Md. Saleh Akram Bhuiyan attended the 2019 Gordon Research Conference on the Science of Adhesion in South Hadley, MA.

Lee gave an invited talk entitled “Smart Bioadhesive Inspired by Mussel Adhesive Chemistry.” Pinnaratip gave an oral and a poster presentation entitled “Regulation of Hydrogen Peroxide Concentration from Mussel-inspired Adhesive via Surface-modified Silica Particle Incorporation,” a project directed by Lee. Bhuiyan gave a poster presentation entitled “Direct Deactivation of Catechol-Containing Adhesive using Electrochemistry,” a project directed by Lee.