Tag Archives: Spring 2010

Developing artificial cells for therapeutic applications and refining bone marrow stimulation techniques for cartilage repair

Department of Biomedical Engineering Seminar: April 5: Dr. Hongmei Chen, Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique of Montreal, Canada, titled, “Developing artificial cells for therapeutic applications and refining bone marrow stimulation techniques for cartilage repair,” at 3 p.m., in Fisher 129


Biologically Inspired Tissue-Engineered Bone and Cartilage Substitutes: A Next Generation Treatment for Musculoskeletal Injuries and Diseases

Wednesday, February 24
G06 Rekhi Hall
3:00 pm

Presenter: Lijie Zhang, PhD, Harvard Medical School, Brigham and Women Hospital, Department ofMedicineHarvard-MIT Division of Health Sciences and Technology (HST)

Abstract: Various bone and articular cartilage defects, caused by trauma, disease or age-related degeneration, representa crucial clinical problem all over the world. However, traditional implant treatments may cause manycomplications after surgeries, leading to intense patient pain. Thus, our research aims to create biologicallyinspired tissue-engineered bone, cartilage and osteochondral substitutes via state-of-the-art nanotechnologyand biotechnology for replacing damaged or diseased musculoskeletal tissues and recovering theirfunctionality.For this purpose, we have designed a series of nanostructured scaffolds with excellent cytocompatibility andmechanical properties based on biomimetic nanoceramic particles, rosette nanotubes (a novel biologicallyinspired nanotube obtained through the self-assembly of DNA base pairs in water), collagen and hydrogels.Different cell types including osteoblast (bone forming cell), endothelial cell, mesenchymal stem cell andfibroblast responses towards these nanocomposites were investigated. Our results demonstrated that thesebiomimetic nanocomposites with controllable surface chemistry can significantly enhance bone cellfunctions and osteogenic differentiation of mesenchymal stem cells, thus making them promising for furtherstudy in bone tissue engineering and orthopedic applications. Furthermore, I will also introduce our work incartilage tissue engineering. Through a novel self-assembling tissue engineering method, a cartilageconstruct was grown from chondrocytes and the mechanical, optical properties and extracellular matrixdistribution of these constructs were measured over times. In summary, the results of our study indicate theimportance of tissue-engineered bone and cartilage substitutes for improving current therapies ofmusculoskeletal disorders and diseases.



When Nano Meets Bio!

Monday, January 25
218 EERC
3:00 pm

Presenter: Kyung A. Kang, PhD, Department of Chemical Engineering, Professor and Graduate Program Director, University of Louisville

Abstract: Nano-sized particles have properties that are highly beneficial for biomedical applications.  Liposome and some biopolymeric nanoparticles have been already used for drug delivery.  Our group has been interested in developing metal nanoparticles for diagnosing and treating diseases.  A few examples of these nano-entities are listed below.

Optical Contrast Agent for Molecular Sensing. Fluorophores have been used as a signal mediator in biosensing and imaging for a long time.  Gold nanoparticles (GNP) possess high-density surface plasmon polarion fields that can be effectively used to enhance the sensitivity of bio- sensing and imaging.  We have been developing a highly specific, molecular beacon-like optical contrast agent for accurate  cancer detection/diagnosis utilizing the GNP’s ability of fluorescence quenching and enhancement ability.

Nanoparticle Mediated Hyperthermia.  An alternating electromagnetic (AEM) field at an appropriate frequency can heat nano-sized magnetic particles (MNPs) without heating surrounding tissue.  When iron oxide MNPs are used for cancer treatment (hyperthermia) they can guide the heat generated  by the non-invasively applied AEM field specifically to the tumor, minimizing normal tissue damage.  We have studied and designed novel AEM probe configurations for more user-friendly AEM energy application to the human body.

Multi-functional Nanoparticles.  Several metal nanoparticles also provide good contrast for imaging, e.g., iron oxide particles are a good MRI contrast agent and gold particles enhance the contrast of X-ray/CT.  By combining these beneficial features, multi-functional nano-entities can  be developed, enabling seamless disease diagnoses and treatment.


Histotripsy: Imaging Guided Ultrasound Therapy for Non-invasive Surgery

Friday, January 22
130 Fisher
2:00 pm

Presenter: Zhen Xu, PhD, Assistant Professor, Dept. of Biomedical Engineering, University of Michigan

Abstract: Histotripsy is a new non-invasive technique  that mechanically fractionates and removes soft tissue using high intensity ultrasound pulses. By focusing ultrasound pulses to the targeted tissue inside the body, histotripsy produces a cluster of energetic cavitation microbubbles within a treatment region. These microbubbles, each similar in size to individual cells, function as “mini-scalpels” to mechanically fragment and subdivide targeted cell and tissue structures. Meanwhile, the tissue outside the treatment region remains intact. The histotripsy treatment is guided and monitored  by ultrasound imaging  in real-time. Histotripsy has potential for many clinical applications where non-invasive tissue removal is desired. My work focuses on cardiovascular and fetal therapy applications. I will talk about my current projects, including histotripsy for breaking  down diseased blood clots (thrombolysis), creating intracardiac communications for congenital heart diseases, and prenatal therapy.