Day: May 16, 2024

Copper Shores Community Health Foundation Assistantship – Summer 2024 – Libia Hazra

Libia Hazra leaning against a tree
Libia Hazra – Environmental Engineering

With sincere gratitude I extend my heartfelt thanks to Copper Shores Community Health Foundation (CSCHF) for providing me with the opportunity to receive the Graduate Assistantship in Summer 2024.

I am Libia Hazra, a 3rd year full time Ph.D. candidate of Environmental Engineering at the Department of Civil, Environmental and Geospatial Engineering (CEGE), Michigan Technological University, Houghton, Michigan, USA. I work with Dr. Judith A Perlinger and Dr. Noel R. Urban at the Environmental engineering Department. My current research focuses on determining contaminant concentrations of Polychlorinated biphenyles (PCBs) and Mercury (Hg) in fish from Lake Superior and adjacent inland lakes, home to the Keweenaw Bay Indian Community (KBIC), a federally recognized Ojibwe tribe, deeply connected to the land. I am trying to understand the factors such as food web structure and resource availability leading to variations in contaminants concentrations in different lakes by using ecological tracers like Stable Isotope Analysis, e-DNA Metabarcoding. Additionally, I am working on the health for people and fish. Amidst numerous environmental concerns, the difficulties encountered by aquatic life, especially fish, are often overlooked. This transdisciplinary research conducted in partnership with social scientists and tribal members and governmental units will provide critical data about persistent organic pollutants (POPs) in fish. These findings will assist in planning stocking and harvesting practices, reducing exposure to pollutants, ensuring the nutritional and socio-cultural benefits of fish consumption, ultimately improving the public health of the local communities.

I am originally from Kolkata (WB), India. I joined Michigan Technological University in 2022, spring. I stay here with my husband and 6 years old daughter. Before I moved to Michigan Tech, I completed my M.Sc. in Environmental Science at GITAM University, Visakhapatnam, India and worked on toxic analysis in bird and fish tissue from an eminent institute-Salim Ali Centre for Ornithology and Natural History (SACON), India. I served as a lecturer in an undergraduate college, where I taught Environmental Studies. I also have experience working as an administrative assistant in the Clean Combustion Research Center (CCRC) at King Abdullah University of Science and Technology (KAUST), Saudi Arabia. My long-term goal is to contribute significantly to the field of environmental engineering and become a leader in building a sustainable environment and society, by the practical application of scientific and technological solutions. I grew up in a rural part of India and have witnessed firsthand the environmental degradation in all sectors (e.g., air/water/soil pollution) and thoughtless misuse and abuse of natural resources. My state West Bengal, eastern part of India, the cherished cultural connection between fish and humans is facing a formidable challenge due to increasing contamination of aquatic environments. The profound cultural significance of fish, deeply embedded in Bengali traditions and cuisine, is now strained as environmental pollutants jeopardize the health of fish populations. Rampant industrialization, discharge of pollutants, and the presence of heavy metals and persistent organic pollutants in water bodies raise alarming concerns about the safety of consuming fish. This contamination not only poses a threat to the nutritional value of fish, a staple in the Bengali diet, but also undermines the livelihoods of fishing communities and breaks the intricate link between fish and ceremonial practices. In future, I would like to extend my research in my country and contribute significantly.

At Michigan Tech, I am not only gaining valuable knowledge and skills through coursework, literature review, and research endeavors but also emphasizing the importance of effective communication. I firmly believe that fostering community awareness and engagement is essential for promoting environmental health and sustainability. This fellowship provides me with the opportunity to further expand my research and engage in meaningful community outreach efforts. I am eager to leverage this assistantship to advance my research objectives and contribute positively to both academia and society.

Once again, thank you very much CSCHF for your generous support and confidence in my research endeavors. I am tankful to my advisors for their valuable support. I am also thankful to my husband and my daughter for their constant support and love.

Doctoral Finishing Fellowship – Summer 2024 Recipient – Natalie Nold

Outdoor portrait of Natalie Nold in front of a brick wall
Natalie Nold – Chemical Engineering

I am a rising PhD candidate in Dr. Caryn Heldt’s lab researching how to make virus-based pharmaceutical manufacturing more cost-effective and time-effective. Gene therapeutics, a ground-breaking new class of pharmaceuticals that can cure genetic diseases and cancer, often depend on a viral vector to deliver the therapeutic gene. Unfortunately, these therapies often cost over $1 million per treatment and are a financial burden to patients. My research has shown that liquid-liquid extraction can be used to purify multiple viral vectors and could reduce manufacturing costs by over 50% at production scale. We have recently filed a provisional patent for this technology which could significantly reduce the cost burden of gene therapeutics.

I would like to thank my advisor Dr. Caryn Heldt for her technical, professional, and personal mentorship. Her guidance helped me not only to succeed in my projects but also to grow as an independent researcher. I would also like to thank my research lab for their support and friendship. I would like to thank the Graduate School for this finishing fellowship as well as the Chemical Engineering department, the Michigan Translational Research and Commercialization program, and the Cottrell Foundation for their previous financial support. I am excited to take the technical and leadership skills I have gained during this degree and continue working to further research in the gene therapy industry.

Doctoral Finishing Fellowship – Summer 2024 Recipient – Seyedmostafa Rezaeitaleshmahalleh

Mostafa Rezaeitaleshmahalleh standing outdoors under a tree
Mostafa Rezaeitaleshmahalleh – Biomedical Engineering

As a final-year PhD candidate in Biomedical Engineering at Michigan Tech, my research revolves around understanding complex blood flow patterns and their implications for aneurysm development and rupture. Specifically, I focus on two types: intracranial aneurysms and abdominal aortic aneurysms.

In my dissertation, I utilize computational fluid dynamics to simulate blood flow within 3D vascular models extracted from medical imaging data of patients with aneurysms. By applying innovative computational methods, I analyze velocity and wall shear stress characteristics within the aneurysm. This approach has led to the development of new metrics that enhance our ability to distinguish between ruptured and unruptured aneurysms, shedding light on flow conditions indicative of potential rupture. Moreover, I’ve devised a systematic method for assessing the composition of intraluminal thrombosis (ILT). Using deep learning algorithms, I identify the ILT region within the vascular model and employ radiomics to analyze its structural properties. This analytical framework provides novel insights into the ILT region, thereby enhancing our ability to identify abdominal aortic aneurysms at heightened risk of rupture. The final aspect of my doctoral research is to develop a nearly automated pipeline to run CFD simulations with minimal user interaction. This automated workflow aims to eliminate time-consuming and labor-intensive steps, making the process more efficient and user-friendly.

My hope is that this work will one day eliminate the current barrier to integrating CFD simulation into clinicians’ workflow and help doctors leverage CFD simulation in their decision-making process. The quantified measures of flow characteristics and ILT composition may be utilized in the clinical setting to better identify which aneurysms are at high risk of rupture. This could guide clinical decision-making to determine if aneurysm surgery prior to rupture is worth the risk, or if an aneurysm is likely to remain stable, posing minimal risk to the patient’s health.

I want to express my sincere gratitude to the Graduate Dean Award Advisory Panel for granting me this award. I also want to thank my advisors, Dr. Jingfeng Jiang, and my committee members, Dr. Sean Kirkpatrick, Dr. Hoda Hatoum, and Dr. Weihua Zhou, for their invaluable guidance and expertise throughout my time at Michigan Tech. Their mentorship has been crucial in shaping my research and academic journey.