Biological Sciences Blog

Category: News

NIH Grant Helps Dr. M. Tang Explore Cancer Mechanisms and Novel Treatments

Published
By
Mark Tang
Mark Tang

Xiaohu (Mark) Tang’s Laboratory of Cancer Metabolism and Functional Genomics is using a three-year $413,090 grant from the National Institutes of Health to find ways to optimize the efficacy of targeted cysteine therapy and broaden its application for the treatment of different subtypes of breast cancer. Tang is an assistant professor of Biological Sciences. He earned his Ph.D. at The Weizmann Institute of Science. Haiying Liu, Professor of Chemistry, is a co-investigator on this project.

“Targeted cancer therapy is an emerging trend in precision cancer medicine,” Tang explains. “It uses the specific genetic makeup of a patient’s tumor to select the safest and most effective personalized treatment, instead of the traditional symptom-driven practice of medicine. Identifying and targeting metabolic vulnerabilities in cancer is a promising therapeutic strategy.”

The NIH grant will also provide research-based training for undergraduates and graduate students in Biological Sciences and the Biochemistry and Molecular Biology programs. “The work will enable students to understand the complexity of cancer and motivate them to seek novel strategies to improve health issues,” says Tang.

Tang’s lab works to characterize the deregulation of cancer metabolism and the role of nutrients during cancer initiation and progression. He is working to understand the underlying mechanisms of cancer to pursue workable alternative treatments for patients. He also hopes that a better understanding of diet-cancer interactions could establish a strategy for long-term cancer prevention.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

Erika Hersch-Green Receives NSF CAREER Award

Published
By

Erika Hersch-Green, plant evolutionary ecologist and associate professor of Biological Sciences, received a National Science Foundation CAREER Award. She will investigate how specific attributes of plants, such as their genome size, influence community biodiversity responses to increased nitrogen and phosphorus availability. Hersch-Green’s approach combines molecular, cytological, physiological, and phylogenetic techniques.  

Erika Hersch-Green
Erika Hersh-Green

Hersch-Green is conducting her research on three fronts. First, she is currently gathering fresh data and merging it with information from experimental grassland sites around the world. These sites have plots with different nutrient treatments, allowing her to examine how response patterns vary depending on climate conditions. Second, she is conducting controlled greenhouse studies to better understand mechanisms that focus on two common grassland plants: fireweed and goldenrod, both of which she has studied before. Lastly, she developed a new research site at Churning Rapids, north of Hancock and south of McClain State Park. There she is extending her research to look at how disturbance patterns affect levels of biodiversity. 

She is also exploring ways to improve students’ scientific literacy and engagement in research.  To accomplish this, she is incorporating students in grades 6 through 12 and undergraduates in research, enhancing research involvement in the classroom, facilitating effective scientific communication skills of graduate students, and promoting collaboration among undergraduate students and faculty in the Departments of Biological Sciences and Humanities. These students will produce video content that will be used to enhance education and public understanding of biological science and ecology.

To summarize, Hersch-Green aims to provide a system-level understanding of how nutrient eutrophication—the increasingly dense growth of particular plants at the expense of other species—and landscape disturbances affect individual organisms and multi-species communities by looking at their interactions.

Although she is passionate about her research, Hersch-Green is also deeply committed to the educational component of her CAREER award. Her educational goals are to increase both scientific literacy and engagement of high school and university students on critical topics related to nutrient eutrophication, biodiversity, evolutionary adaptation, and awareness of related STEM (science, technology, engineering, and math) career pathways. 

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

Anatomage Table 8.0 is a True Game Changer for Students

Published
By
Students standing beside an interactive table in a lab
Students using Anatomage Table in A & P

Thanks to the generous support from our alumni and friends, the department purchased a virtual human cadaver dissection table from Anatomage. The table cost about $72,000. Our Anatomy and Physiology (A & P) students have been excited to use this equipment since the Fall of 2021. The table will move to our new H-STEM building when that project is complete (and be joined by a second table). This 7.2-foot-long iPad-like table allows eight students to simultaneously learn and experience medical sciences in a way they have never done before! We would greatly appreciate it if you could contribute to Anatomage Michigan Tech Fund #3454. Funds will go to purchase a second Anatomage table. As a result, this increases instruction for up to 16 students at the same time. We are already halfway there. 

The Anatomage Table 8.0 is one of the most technologically advanced virtual dissection platforms. The Table’s interactive, life-sized display is now available for our undergraduate students to utilize within the Anatomy & Physiology Teaching Laboratory! It expands our ability to provide ultra-high-quality visualization for students to view photorealistic anatomical structures. Students are amazed by the level of detail within each virtual human cadaver. They see value in comparing models and textbook images to actual medical images. The Table includes a robust library of histology scans, CT and MRI scans, clinical cases, and physiology simulations. 

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

Paul Goetsch Receives NIH Grant to Study Cell Cycle Regulation

Published
By
Dr. Goetsch assisting a graduate student in the lab

Assistant Professor Paul Goetsch received a $423,381 grant from the National Institutes of Health. Dr. Goetsch will study how the DREAM transcriptional repressor complex regulates the cell cycle of cellular progression and cellular quiescence.

Cellular division is extremely important as an organism grows to maturity, but just as important are the mechanisms that stop cells from dividing. Dysfunction in cellular quiescence generally leads to the development of cancer cells, Goetsch explains.

Working in the model system Caenorhabditis elegans, a 1 mm-long transparent nematode, the Goetsch lab is using CRISPR/Cas9-mediated genome editing to disrupt how the DREAM complex forms and test how that affects its function. “By exploiting advances in genomic editing and genetic tools in a tractable model system, we will gain new insights into how the DREAM complex protects cellular and organismal health,” says Goetsch.

Another part of the grant supports bringing research directly into the classroom for Biological Sciences students in the second-year genetics lab. Goetsch and his colleagues are implementing Course-based Undergraduate Research Experiences (CUREs). These are used to provide students a glimpse into research opportunities within the department.

In Spring 2021, Goetsch and his student Emily Washeleski developed a unique experiment combining C. elegans genetics with environmental microbiology. “We are continuing to expand upon our CURE approach to provide students equitable access to research experience as a cornerstone of their professional development within the department,” Goetsch says.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

Alumni and Friends Inducted into the CSA Academy

Published
By
Steve Yang
Steve Yang

Steve Yang

Dr. Steve Yang was inducted into the CSA Academy of Sciences and Arts on September 15, 2022. Dr. Yang is the Co-CEO of WuXi AppTec and a member of its board of directors. He is also WuXi AppTec’s Head of WuXi Biology and Head of WuXi Testing businesses. His responsibilities include the management of multiple business units and commercial operations. WuXi AppTec provides a broad portfolio of R&D and manufacturing services. These enable companies in the pharmaceutical, biotech, and medical device industries worldwide to advance discoveries and deliver groundbreaking treatments to patients.

Dr. Yang received his Ph.D. in Pharmaceutical Chemistry from the University of California, San Francisco. He started his undergraduate study at Fudan University, China. Yang completed his B.S. degree (Summa Cum Laude) in biological sciences from Michigan Technological University. He co-founded the BayHelix Group and served as the board’s chairman for two terms. BayHelix Group is a non-profit global professional organization of Chinese life science business leaders. We are proud of all of Steve’s achievements and welcome him back to engage with our students and curriculum improvements.

James Spain
James Spain

James D. Spain

Professor James D. Spain, PhD. was inducted into the College of Sciences and Arts Academy on October 7, 2021. He is one of the founding members of the Department of Biological Sciences at Michigan Technological University. Dr. Spain started our department in 1962 and served as the first department head from 1962 to 1968. Dr. Spain played a major role in developing a strong curriculum in biological sciences at the B.S. level. He helped offer M.S. and Ph.D. programs in biological sciences in 1965 and 1970, respectively. He initiated interdisciplinary research in aquatic ecology. Dr. Spain was actively engaged in research in biochemistry with a special emphasis on chemical carcinogenesis. He was passionate about developing tools and offering courses in “Computer Applications in Biology”. He received Michigan Tech’s highly prestigious Faculty Research Award in 1965.

Dr. Spain took early retirement from Michigan Tech in 1984 and continued his career, first at Eastern Michigan University as their director of Instructional Computing. Later, at Clemson University in South Carolina, he directed the Chemistry Learning Center. Dr. Spain retired in 2010 and returned to the Copper Country. He recently published his autobiography, Perusing for Pioneer Pathways. We are grateful to Professor Spain for all that he has done for our department. The seed he planted in 1962 has now grown into this majestic tree that has witnessed the graduation of thousands of students since 1963.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

2021 Provost Award Winner Says Research, Clinical Care Go Hand in Hand

Published
By

Thomas Basala was the recipient of the 2021 Provost’s Award for Scholarship. He graduated in May with a Bachelor of Science in Human Biology.

Basala is spending the summer as a lead intern at the Minneapolis Heart Institute Foundation. He will stay there for the rest of this year as a research associate. He plans to attend medical school.

Thomas Basala
Thomas Basala, 2021 Provost Award Winner

The Provost’s Award for Scholarship recognizes a student who embodies Michigan Tech’s scholarship value statement: We inspire world-class scholarship through academics, research, and continued learning. It is awarded annually to a rising senior who has demonstrated excellence not only in academics but also in research, levels of intellectual curiosity, creativity, and communication skills.

Each department is invited to nominate one undergraduate for the award. In 2021, Basala was the Department of Biological Sciences’ nominee.

“Thomas is one of the most conscientious, reliable, and appreciative students I have met,” says John Durocher, adjunct associate professor of biological sciences. Basala worked in Durocher’s lab.

Basala says winning the Provost’s Award caught him by surprise. “There are so many talented students at Michigan Tech,” he explains.

A student in the Pavlis Honors College, he worked in the Clinical and Applied Physiology Lab throughout his years at Michigan Tech. He received two research grants while he was an undergraduate: a Michigan Space Grant Consortium young investigator award to study how nocturnal blood pressure relates to indices of cardiovascular risks such as arterial stiffness; and a Summer Undergraduate Research Fellowship (SURF) to investigate the efficacy of pre-sleep meditation on sleep in young adults. “They were both very enriching to me,” he says.

Basala presented his meditation research at the 2022 Experimental Biology conference in Philadelphia. Additionally, he presented work on the impact of decentering—the ability to dissociate from emotional feelings—on nocturnal blood pressure patterns at the 2021 Experimental Biology conference. Both abstracts were published in the FASEB (Federation of Societies for Experimental Biology) Journal.

He fell in love with research under Durocher’s mentorship. “He taught me the minute nuances of doing human research,” Basala says. ‘He helped me understand what it means to be a well-rounded researcher and active community member. “

Basala wants to become that kind of clinician/researcher. “I want research always to be part of the patient care I do,” he says. “Research and clinical care inform each other and, in many cases, should not be separated.”

Basala is from Stevens Point, Wisconsin. During his time at Tech, he served as president of the Triangle STEM (Science, Technology, Engineering, and Math) fraternity, a lieutenant with Michigan Tech EMS (Emergency Medical Services), and co-coordinator for the Global and Community Engagement Conference.

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

2022 Graduate Found Her Passion in Medical Laboratory Science

Published
By

Brooke Tienhaara graduated from Michigan Tech in May with a Bachelor of Science in Medical Laboratory Science. Now she’s doing a 42-week internship at Ascension Health’s St. Joseph’s Hospital in Detroit.

Tienhaara, whose mother is a nurse, always knew that she wanted to work in the medical field. But she wasn’t sure what career would capture her interest. Her sister, Taylor, who also graduated from Michigan Tech in Medical Laboratory Science, thought she would do well in that field too. So Tienhaara decided to give it a try.

Brooke Tienhaara
Brooke Tienhaara, 2022 Graduate

A Calumet native, Tienhaara chose Michigan Tech because, she says, “If I went somewhere else, it felt like I would have missed an amazing opportunity to go to a great school that was close to everything and everyone I loved.”

As she entered her junior year, when she would have gotten hands-on experience in the lab, the COVID pandemic hit. “I didn’t do well with online labs,” she says. “I need more structure than that.” She found it hard to concentrate, to focus on her studies. The year before she was due to graduate, she dropped out of school, losing the semester she was in and her final semester.

Coming out of her depression was a slow and difficult process. “It was a team effort,” she says. Her family, friends, therapy, and work at her job all supported her recovery, as well as a healthy helping of Finnish sisu.

“I wanted to get my degree,” Tienhaara explains. “I knew I could do it.”

So she re-enrolled at Michigan Tech, patiently retaking all the classes from the semester she dropped out and finishing her final semester.

She did so well that she was invited to speak at the May 2022 Commencement.

While she was at Tech, Tienhaara was active in the Health Occupations Students of America and Students of Medical Laboratory Science. She volunteered with the university’s food pantry and worked with Autism Speaks, arranging and chaperoning events for children on the autism spectrum. “I really enjoy working with children,” she says.

Tienhaara is excited about her medical laboratory internship in Detroit. “This internship will give me the real-life experience of working in a lab,” she explains. “I’ll be getting to try everything—microbiology, chemistry, hematology, blood banking. It will help me find out what I like best.”

She hopes her future will include some research. “I wish I had gotten involved in research at Michigan Tech, but I didn’t have the chance.”

Tienhaara has some advice for incoming Michigan Tech students. “Take every opportunity that is presented to you. Don’t waste your time here. My only regret is the stuff I didn’t do.”

This blog post initially appeared in the Fall 2022 Biological Sciences Newsletter. Read this article and others like it today.

Continue Reading →

Human biology students win top awards at Michigan Tech

Published
By

It is rare that a student in one department wins major end-of-year awards at Michigan Tech. So imagine how excited we were to have two! Congratulations to our outstanding award-winners in the biological sciences department who are also part of our pre-health program. 

Christian Johnson wins the Provost’s Award for Scholarship

First to Christian Johnson, winner of the Provost’s Award for Scholarship. The Provost’s Award for Scholarship is given “to a senior who best represents student scholarship at Michigan Tech. This outstanding student is considered excellent, not only by academic standards, but also for participation in research, scholarship activity, levels of intellectual curiosity, creativity, and communication skills.”

Image of Christian Johnson, the Provost's Award for Scholarship winner
Christian Johnson, the Provost’s Award for Scholarship winner

“I am thrilled to see that Christian was selected for the Provost Award for Scholarship.  I have had the honor to work with Christian over the past 3 years as his Pre-Med Advisor,” says Nicole Seigneurie, director of pre-health professions and instructor of biological sciences. “I can’t say enough how outstanding a student Christian is. He has always impressed me with his passion, commitment to community service, work ethic, and servant leadership. On top of that, he is a very kind and compassionate individual who I know is destined for great things. This award was well-deserved!” 

Stephanie Carpenter, assistant professor of creative writing describes Christian as “an inventive, dynamic writer and an engaged, generous participant in discussions of published and student works” who is “a stand-out in our department and at Michigan Tech.” Christian added the English major, a move that he feels will help him to be a more empathetic physician and to develop the critical thinking and writing skills he will need to be successful in medical school.

And Travis Wakeham, lecturer and undergraduate academic advisor in biological sciences adds, “It has been an absolute pleasure watching Christian grow into an empathetic leader through his involvement in a wide variety of activities. Few students can balance conducting research in cardiovascular physiology, pursuing various artistic endeavors (including actively working on two novels), assisting people through a crisis as a volunteer at Dial Help, while finding time to play through a Dungeons and Dragons campaign between all of his schoolwork. He truly represents some of the best scholarship at Michigan Tech.
Pursuing a double major in English and human biology with a pre-health professions minor, Christian’s diverse passions and accomplishments led to his selection as the Departmental Scholar for both Humanities and the Pavlis Honors College. We thank Christian for his scholarship and academic accomplishments, as well as his tireless commitment in serving the Michigan Tech community.

Bella Menzel-Smith wins William and Josephine Balconi Community Service Award

And congratulations to Bella Menzel-Smith for winning the 2022 William and Josephine Balconi Community Service Award! The William and Josephine Balconi Community Service Award is “presented to a student who demonstrates community service with lasting and meaningful impact during their time at Michigan Tech, regardless of background or area of study.”

Image of Bella Menzel-Smith William and Josephine Balconi Community Service Award winner at Michigan Tech
Bella Menzel-Smith, the William and Josephine Balconi Community Service Award winner

Dr. David and Marie Blum initiated this endowment in memory of Marie’s parents, Josephine and William Balconi. David and Marie remember Marie’s parents as “kind, gracious, warm, and always helpful. They were always involved in helping others.” Marie’s parents lived in the Houghton area.

“I was so honored to be able to nominate Bella for the Willman and Josephine Balconi Community Service Award,” says Nicole. “Bella embodies everything this award stands for. She has a real passion for helping others through service and she’s left such an incredible impact on both the Tech and Houghton community. I am excited to see where the future takes her as she embarks on her next chapter, Physician Assistant School. I am confident Bella will continue to have a positive impact on her future patients and the communities that she will serve in the future.” 

Travis adds, “Bella energizes any room that she walks into with her positive attitude and dedication to serve others. She has made a tremendous impact within our community through her initiatives, including creating a pre-health mentoring program to connect new students with upperclassmen. Her work has helped empower others and bettered their well-being. I have no doubt that she will excel in the Physician Assistant program at Marquette University next and continue to serve others as a healthcare professional.”Bella is a pre-physician assistant student who is majoring in human biology. You can read more about her pathway to Physician Assistant School. We thank Bella for her tireless commitment to community service and passion for helping underserved communities.

Continue Reading →

Rashi Yadav, Biological Sciences Graduate Student Spotlight

Published
By

Rashi Yadav is a final year PhD candidate in Department of Biological Sciences working on L2-based virus-like particles (VLPs) against Human Papillomavirus (HPV) and also, production of thermostable VLP platform. In addition to research, she has taught Molecular Biology, Biochemistry, Environmental Microbiology and General Biology as a Graduate Teaching Assistant.

Rashi presenting

HPVs are associated with 90% of cervical cancer and 25% of oral cancer. Infected individuals clear the infection within two years, however persistent infection can lead to cancer and genital warts. Fortunately, there are two L1- based prophylactic vaccine against HPVs that offers protection against 7 cancer causing HPV types (high-risk HPVs) and 2 low risk HPV types that can cause cutaneous and genital warts. However, there are 19 cancer causing HPV types and current vaccine offer limited cross protection. The outer shell (capsid) of HPV is made of two proteins- major capsid protein (L1) that is not conserved and minor capsid protein (L2), on the contrary, is conserved among different types of HPVs. Rashi’s research is focused on assessing the ability of L2-based VLPs against different types of high-risk and low-risk HPV types. Overall, L2-based VLPs can protect against 12 oncogenic HPV types causing cervical and oral cancer in addition to protection against HPV 5 that causes Epidermodysplasia Verruciformis. Rashi’s second project is on development of novel thermostable VLP platform that can be exploited to expose antigens on the surface against cancer or virus as vaccine.

Rashi working in the Covid-19 diagnostic lab.

Rashi won the first prize in 3 Minute Thesis organized by Health Research Slam where students from various departments participated and was awarded a check of $300. The topic of her presentation was “”Oral immunization with bacteriophage MS2-L2 VLPs protects against oral infection with multiple HPV types associated with head and neck cancers ”

Rashi is also working in MTU Covid-19 diagnostic lab. She is one of the few students who joined the lab and helped set up the lab including training and supervising students in RNA extraction of samples. She also prepares viral transport media which is exported to number of health facilities around the city to obtain samples for testing.

Continue Reading →

Student artist Mara Hackman (MLS) – Outdoor Sculpture 2020

Published
By
Student artist Mara Hackman sitting around her outdoor sculpture "Space"

This summer, Lisa Gordillo (VPA) is teaching Michigan Tech’s first fully-online sculpture class. Students focus on making works or art outside, and use the landscape around them as their studio. Because we’re several months into “social distancing” and many folks are longing for connection, Gordillo worked to make a class that creates connections with community (even at a distance). Student sculptors consider art, ecology, and social connection as they make new works of art this summer. 

One student artist in the class is Mara Hackman, an undergraduate student in Medical Laboratory Science. Hackman’s first sculpture, titled “Line,” was created with a “wave of trash and flowers”. Her sculpture follows the path of a stream near her home. To make this sculpture, Hackman walked her favorite nature trail and gathered the trash she found along the way. She gathered flowers from the trail and her garden, and combined them into this wave to “signify life and repair.” She hopes people will look at this piece and think about both the beauty of nature and the destruction humans can cause.

Student artist Mara Hackman outdoor sculpture "Line"

The second scupture is titled “Space,” as described by Hackman, “I started off by blowing up 240 balloons and started by tying (them) together. You think 240 balloons is a lot, and they almost completely filled up my grandma’s living room – but once I took them all outside in the field, the balloons looked small. The field was very spacious. I did different things with the balloons, pilled them up and made a line, and randomly had them spread out around the field.

I took inspiration from Tierra (2013) by artist Regina JoseGalindo. In Tierra, (the artist stood) in a field as a bulldozer dug out around here leaving less and less space. Having balloons staked around me, made me feel claustrophobic and I felt all this pressure around me. That is where I came up with the idea that all these balloons and their different colors represented the different pressures of my life … which is represented by the balloons surrounding (my sister) Kylee and only leaving her boots left.”

View more on the Outdoor Sculpture 2020 Online Gallery.

Continue Reading →