Author: Lois Hwang

From the very beginning of my academic journey, the intersection of chemistry and biology has thrilled me, as it embodies the essence of interdisciplinary challenges that encourage innovative thinking. Having BS and MS in biochemistry, I joined the Chemistry Department at Michigan Technological University in August 2018 as a Fulbright Graduate Student from Ukraine. Under the mentorship of Dr. Marina Tanasova, I pursued chemical biology research to utilize small molecules produced through synthetic chemistry for the study of complex biological systems.
My Ph.D. research focuses on the development of tools for the targeted detection of disease-relevant sugar transporters (GLUTs) to advance diagnostic and imaging capabilities. Working in Dr. Tanasova’s lab has been an incredibly rich research experience, allowing me to master a diverse set of skills and carry out the whole research project from the beginning to the end. I truly enjoy the process of designing molecules, synthesizing them, and validating their properties through a range of analytical techniques. Witnessing the colorful array of fluorescent probes we have developed and applying them for cancer research has evoked excitement in me. I am genuinely excited about the potential outcomes of my research, as they contribute to the advancement of novel strategies for targeting cancers in both diagnostic and therapeutic applications. Collaborating with other researchers and students, sharing my research, and promoting a safety culture within my department and on the national level have been rewarding and enriching experiences for me during my Ph.D. I am grateful for the opportunities I have had during my graduate program. I am confident that the training I received at MTU has provided me with a solid foundation to realize my research aspirations.
I am honored to be selected as one of the recipients of the Doctoral Finishing Fellowship. I would like to thank the Graduate Dean Awards Advisory Panel and Dean for granting the fellowship to me during this crucial phase of my Ph.D. journey. It is indeed an invaluable opportunity to dedicate my time and efforts to writing my dissertation, preparing for the defense, and embarking on the next chapter of my scientific career. I would like to thank my research advisor Dr. Marina Tanasova for the support and guidance she provided over the last 5 years. Her belief in my potential paved the way for me to transition from a Master’s student to a doctoral candidate, and I am truly grateful for the mentorship and encouragement she has provided. Moreover, I wish to express my gratitude to the Chemistry Department, Dr. Sarah Green, my committee members, and all the individuals who have played a role in shaping me into an independent research scientist.

I began my Ph.D. journey in Chemistry in the Fall 2019 under the guidance of Dr. Tatyana G. Karabencheva-Christova. Prior to joining MTU, I earned a master’s degree in Applied Chemistry from Mahatma Gandhi University and a bachelor’s degree in Chemistry from Calicut University, India. It was during my master’s program that I developed a profound interest in computational chemistry, which ultimately led me to pursue advanced studies in this fascinating field.

My research primarily focuses on exploring enzyme characteristics and mechanisms through the application of multilevel computational methods, including Molecular Dynamics (MD), Quantum Mechanics (QM), and combined Quantum mechanics/Molecular mechanics (QM/MM). During my Ph.D., I had the opportunity to contribute to NIH-funded projects on the non-heme Fe(II) and 2-oxoglutarate dependent oxygenase, Fat mass and Obesity Associated Protein (FTO), and the Zn(II) dependent metalloprotease, Matrix metalloproteinase-1 (MMP-1), both of which have crucial implications in various types of cancers. In the former project, I investigated the enzymatic mechanism of FTO with its major substrate, N6-methyladenine in single-stranded RNA, and explored the influence of clinically relevant mutations Arg316Gln and Ser319Phe on different stages of the catalytic cycle. In the latter, I unraveled the water-mediated catalytic mechanism of MMP-1, conformational dynamics and long-range correlated motions assisting in catalysis and the role of the catalytic and structural Zn(II) ions in the overall stability of enzyme.

I am immensely grateful to the Graduate Dean Awards Advisory Panel and the Dean for recognizing my efforts and awarding me the Doctoral Finishing Fellowship. I extend my heartfelt gratitude to my advisor, Dr. Tatyana G. Karabencheva-Christova, whose guidance and support have been invaluable throughout my Ph.D. journey. I also extend my thanks to all the faculty and staff in the Chemistry department for their encouragement and assistance.