I began my Ph.D. study in 2017 and working with Dr. Xiaoqing Tang in the Department of Biological Sciences. I received my Bachelor of Science degree in Biotechnology from Northwest A&F University in 2016.
My research focuses on the role of miR-483 in pancreatic beta-cells. Pancreatic β-cell dysfunction is central to the development and progression of type 2 diabetes. Dysregulation of microRNAs (miRNAs) has been associated with pancreatic islet dysfunction in type 2 diabetes. I found out that Loss of miR-483 could enhance high-fat diet–induced hyperglycemia and glucose intolerance by the attenuation of diet-induced insulin release. and I further demonstrated that the loss of miR-483 induces expression of Aldh1a3, a marker of β-cell dedifferentiation. My results suggest that miR-483 mimic would be a potential therapeutic target to revert β-cell dedifferentiation and be a treatment of diabetes.
I would like to thank my advisor, Dr. Xiaoqing Tang, for her support and guidance. And I would like to thank the Graduate School, Graduate Dean Awards Advisory Panel, and the Graduate School for providing me with the Finishing Fellowship award. This will allow me to focus on writing and defending my dissertation in Spring 2022.