Tag: Biomedical Engineering

I joined Dr. Bruce Lee’s lab in the Department of Biomedical Engineering in Fall 2016, where we focused on designing biomimetic materials for different biomedical applications. The overall objective of my research is to manipulate a unique reduction-oxidation chemistry found in mussel adhesive proteins to create novel biomimetic model systems for robust antibacterial activity and enhanced wound healing. Specifically, I have been developing biomimetic hydrogel/microgels which can be activated to release Reactive Oxygen Species such as hydroxyl radical (^•OH) and hydrogen peroxide (H₂O₂). ^•OH is an extremely potent oxidizer which, unlike H₂O₂, no known enzyme can detoxify it in the bacteria cells, leading to fast and efficient antibacterial activities. H₂O₂ is a mild oxidizer, which effectively functions as a broad-spectrum biocide and disinfectant in many biomedical applications. The introduction of a relatively high concentration of H₂O₂ is antimicrobial and a relatively lower concentration promoted wound healing. We are anticipating that our H₂O₂-releasing hydrogels can serve as a simple and inexpensive approach for the treatment of healing-impaired wounds such as diabetic foot ulcers.

I would like to thank Dr. Lee for his valuable guidance and support. I am also incredibly grateful to the Graduate Dean Awards Advisory Panel and the Graduate School for awarding me Finishing Fellowship. This will allow me to concentrate on my research and complete my doctoral project in Spring 2021.

I began my doctoral research in the Fall of 2016 in the Biomedical Microdevices lab under the guidance of Dr. Smitha Rao and Dr. Marina Tanasova (Department of Chemistry). My research focuses on understanding compromised metabolic processes in breast cancers and their impact on the local tumor environment and cancer metastasis using a microfluidic platform.  The overall objective is to better understand the nutrient microenvironment and impact from the nutrients available in the body on breast cancer, to improve cancer detection and therapy.  My doctoral work also includes developing three-dimensional in vitro models for understanding cancer microenvironment and metabolic differences, differential uptake of fructose among breast cancer phenotypes, and develop a platform for cancer diagnostics.

I thank the Michigan Tech Grad School for the fellowship and the Department of Biomedical Engineering for their support.

I am a PhD Candidate in my final year with the Biomedical Engineering department at Michigan Tech. My research focuses on the study of complex swirling blood flow patterns and how analyzing their characteristics can help to better understand the development, growth, and rupture of cerebral aneurysms. In my doctoral dissertation, I have utilized computational fluid dynamics to simulate blood flow patterns in 3D vascular models taken from medical imaging files of patients with cerebral aneurysms and applied a novel computational analytic method to identify areas of complex swirling flow and measure their changes over the cardiac cycle. This has led to novel quantified metrics that can improve statistical models to predict areas of aneurysm development, and improve models capable of differentiating ruptured and unruptured aneurysms giving new insights into flow conditions suggestive of aneurysm rupture that are often overlooked in other studies. The final aspect of my doctoral research is to use a specialized flow chamber to expose human vascular endothelial cells to multiple areas of swirling flow, with each area having varied spatiotemporal characteristics. These cells will be analyzed to see if varied swirling flow characteristics lead to differing levels of cellular changes indicative of aneurysm rupture: expression of cell-to-cell adhesion proteins, inflammatory markers, and levels of cellular apoptosis (death).

My hope is that this work will one day help doctors further understand the complex nature of aneurysms, and that the quantified measure of swirling flow characteristics will be utilized in the clinical setting to better identify which aneurysms are at high rupture risk. This could help guide clinical decision making to determine if aneurysm surgery prior to rupture is worth the risk, or if an aneurysm is likely to remain stable, posing minimal risk to patient health.

I am extremely grateful to Michigan Tech’s graduate school for this financial support, allowing me the opportunity to finish my research. I also would like to express my gratitude to my advisors Dr. Jingfeng Jaing and Dr. Feng Zhao (now faculty at Texas A&M), as well as my committee members Dr. Sean Kirkpatrick, Dr. Gowtham, and Dr. Min Wang for their expertise and guidance throughout my research at Michigan Tech.

Samerender Nagam Hanumantharao
Biomedical Engineering

I moved to the city of Houghton to pursue my M.S. degree in Biomedical Engineering in Fall 2015. I completed my Masters’ thesis, titled “ A 3D Biomimetic Scaffold using Electrospinning for Tissue Engineering Applications” under the guidance of Dr. Smitha Rao in Spring 2017. I continued to work with Dr. Rao in pursuit of my Ph.D. My PhD work focuses on understanding and exploiting the role of biomechanical cues in chronic wound healing and cancer. Interestingly, these two diseases share some common factors that can be used to make bandages that can accelerate wound healing or trap metastatic cancer cells.  I want to thank the Graduate School for the funding during the last stage of my research.