Hao Meng, Yuan Liu and Bruce P. Lee have co-authored “Model Polymer System for Investigating the Generation of Hydrogen Peroxide and its Biological Responses during the Crosslinking of Mussel Adhesive Moiety” in Acta Biomaterialia.
To harvest the unique underwater adhesive properties of mussel adhesive proteins, scientists have designed various synthetic mimics of these proteins to create novel biomedical adhesives, drug carriers, and tissue engineering scaffolds.
The team designed a model system to systemically characterize the biocompatibility and biological responses associated with the byproduct (i.e., hydrogen peroxide) generated during the curing process of biomimetic adhesive moieties.
Hydrogen peroxide is an important biological molecule with multiple biological functions (i.e., wound healing, disinfectant, etc.). This is the first report to characterize the release of hydrogen peroxide during the curing process of the mussel adhesive moieties; however, the biocompatibility of these biomimetic materials have not been fully characterized.
Bruce P. Lee and Pegah Kord Forooshani published “Recent Approaches in Designing Bioadhesive Materials Inspired by Mussel Adhesive Protein” in the Journal of Polymer Science Part A: Polymer Chemistry.
Mussels can bind to various wet surfaces, such as a ship hull or rock, through the secretion of adhesive proteins.
This paper reviews the remarkable underwater adhesion of these proteins, which have inspired many scientists to incorporate such unique chemistries into the design of a wide range of materials. The chemistry extents to biomaterials, such as adhesives, coatings, and therapeutic drug carriers, as well as to smart materials, like smart adhesives, actuators, and self-healing materials.
This is an invited and peer-reviewed review article which provides a comprehensive and updated information on how the adhesive proteins function and methods for using these designs to create new and improved functional materials.
Bruce Lee (Bio Med) and graduate student Ameya Narkar (Bio Med) coauthored the paper “pH Responsive and Oxidation Resistant Wet Adhesive based on Reversible Catechol-Boronate Complexation.” The paper was published in Chemistry of Materials. This paper was also coauthored by Tech alumni Brett Barker and Matthew Clisch, as well as Jingfeng Jiang (Bio Med).
Could 3D Printing Provide an Alternative to Plaster Casts?
Anyone who has ever had a broken arm, sprained ankle or anything that requires wearing a cast undoubtedly remembers how uncomfortable it was. Sure, it was fun to get everyone’s signature on your arm or leg, but that didn’t make up for the itchiness, the rash and the difficulties involved when taking a shower. A bright team of engineers at Michigan Technological University thought there had to be a better solution, and came up with a lightweight, porous, 3D-printed alternative instead.
Dr. Jingfeng Jiang, leader of the project, commented: “The Lightweight Structures Module enabled us to rapidly design and create prototypes of these orthopaedic casts given any patient-specific wrist geometry. Furthermore, the software allowed us to export the virtual design directly to ANSYS for FEA analysis, so that we could make sure the model was strong enough to withstand different loading conditions.”
Feng Zhao (Bio Med) is the principal investigator on a project that has received a $465,000 research and development grant from the U.S. Department of Health and Human Services-National Institutes of Health.
Jeremy Goldman (Bio Med) is the Co-PI on the project “Therapeutic Lymphatic Vessel Regeneration.” This is a three-year project.
How do discoveries in university labs turn into commercially available—and potentially lifesaving—products?
This Wednesday, May 25, 2016, teams of Michigan Tech scientists and engineers will present their innovative technologies to a state funding review committee. The reviewers, officially designated an Oversight Committee, will be making decisions on grants from the Michigan Translational Research and Commercialization (MTRAC) program, a $6 million state-funded program developed and managed by the Michigan Economic Development Corporation (MEDC) to help commercialize university translational research.
An example of a team that will present on Wednesday afternoon is Professor Jarek Drelich (MSE) and Associate Professor Jeremy Goldman (BME). They are working on developing a metal alloy that would perform well as a biodegradable stent for heart surgery and other uses where a biodegradable material is desirable. They have been working for some time to find a material with all the necessary properties that will biodegrade harmlessly in the body over a set period of time.
On April 18, 2016, the Department of Chemical Engineering hosted its Order of the Engineer induction ceremony.
The ceremony welcomed 53 new members to the order, including two biomedical engineers and three faculty and staff members.
In 2015, 27 members were inducted, bringing the total of the Michigan Tech Chemical Engineering cohort to 134 since 2014.
Read more at Tech Today, by Chemical Engineering.
Bruce Lee (Bio Med/LSTI) is the principal investigator on a project that received a $294,960 research grant from U.S. Department of Defense, Office of Naval Research. The project is entitled “Smart, Moisture-Resistant Adhesive Inspired by Marine Chemistry.”
This is the first year of a potential three-year project that could total $517,588.
Biomedical Engineering Graduate Seminar: Friday, October 30-3:00 pm, U113 M&M
The Department of Biomedical Engineering presents: Dr. Kui Zhang, Professor, Mathematical Sciences, Michigan Technological University
Title: Design and Analysis of Next Generation Sequencing Data
In this talk, I will present my recent research on design and analysis of next generation sequencing (NGS) data. The talk can be divided into two parts. The first part of the talk will focus on developments of novel statistical methods. The Hidden Markov Model in genotype calling from NGS data will be intro-duced. Its extension that can use additional information from sequencing reads for improvements will be described. The further extensions that can use family samples and admixed sample will be discussed. The second part of the talk will mainly be on several collaborative projects including the identification of genetic variants that are associated with HIV infection in a genetic association study, a study with the RNA sequencing technologies, etc. The problems and the statistical methods used in these analysis will be discussed.