Graduate School Newsblog

Tag: Portage Health Foundation

Portage Health Foundation Graduate Assistantship Spring 2020 Recipient – Avik Ghosh

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Avik Ghosh
Biochemistry and Molecular Biology

I joined Dr. Tanasova’s Lab as a PhD student in the Department of Biochemistry and Molecular Biology in Fall 2017. My research focuses on exploring the impact of nutritional deprivation in cancer cells. Nutritional deprivation has been of interest to the research community as an approach to sensitize cancer cells towards chemotherapy. While many strategies have been undertaken, it is still not clear whether such an approach can be safely applied to all types of cancers. As a researcher in the Tanasova laboratory, I am aiming to understand the outcomes of fructose deprivation in different cancer types.

Our recent development of fluorescent probes that can specifically target cancer-relevant fructose transporter GLUT5 made it possible to conduct targeted studies on assessing the role of this transporter in cancer. Through preliminary assessments, I have found that depriving cancer cells in fructose through GLUT5 inhibition induces different responses in different cancer types. I discovered that in aggressive breast cancer phenotypes, such deprivation causes long-term stress that could positively contribute to the outcome of chemotherapy. In contrast, at an early stage, cancer cells appear to adjust to the induced deprivation and gain resistance. This observed difference provides an essential insight into the diverse nature of cancer and allows us to rationalize the choices of treatment better.

However, considering a required high-level experimental rigor, I still need to perform a large number of experiments that will validate the discovery from different angles. The work will include couple of challenging analyses that are known to be time-consuming and require tuning of conditions to achieve results.

Thus, I sincerely thank Portage Health Fellowship for the support. The award has not only taken care of my tuition/stipend support but also has bought me time from my daily teaching responsibilities to focus on my research better. I would also like to thank my advisor Dr. Marina Tanasova and the Department of Biochemistry and Molecular Biology for the constant support and guidance.

 

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Portage Health Foundation Graduate Assistantship Spring 2020 Recipient – Pegah Kord Forooshani

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Pegah Kord Forooshani
Biomedical Engineering

I joined Dr. Bruce Lee’s lab in the Department of Biomedical Engineering in Fall 2016, where we focused on designing biomimetic materials for different biomedical applications. The overall objective of my research is to manipulate a unique reduction-oxidation chemistry found in mussel adhesive proteins to create novel biomimetic model systems for robust antibacterial activity and enhanced wound healing. Specifically, I have been developing biomimetic hydrogel/microgels which can be activated to release Reactive Oxygen Species such as hydroxyl radical (OH˙) and hydrogen peroxide (H2O2). OH˙ is an extremely potent oxidizer which, unlike H2O2, no known enzyme can detoxify it in the bacteria cells, leading to fast and efficient antibacterial activities. H2O2 is a mild oxidizer, which effectively functions as a broad-spectrum biocide and disinfectant in many biomedical applications. The biological responses to H2O2 are highly dependent on its concentration. The introduction of a relatively high concentration of H2O2 is antimicrobial and a relatively lower concentration promoted wound healing. We are anticipating that our H2O2-releasing hydrogels can serve as a simple and inexpensive approach for the treatment of healing-impaired wounds such as diabetic foot ulcers.

I would like to thank Dr. Lee for all of his valuable guidance and support which have provided me with the opportunity to expand my knowledge and skills. I am also incredibly grateful to the Portage Health Foundation for awarding me this assistantship which will enable me to concentrate on my research and complete my doctoral project.

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Summer 2020 PHF Graduate Assistantship Nominations Open

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Applications for summer 2020 PHF Graduate Assistantships are being accepted and are due no later than 4pm, March 3, 2020 to the Graduate School. Instructions on the application and evaluation process are found online. Students are eligible if all of the following criteria are met:

  1. Must be a PhD student participating in health-related research that is aligned with the PHF’s mission.
  2. Must be eligible for or in Research Mode at the time of application.
  3. Must be 2 years after starting the graduate program at the time of application.
  4. Must not be a prior recipient of a PHF Graduate Assistantship.

Priority will be given to students originally from Houghton, Keweenaw, Baraga, or Ontonagon counties. Non-resident students and international students are encouraged to apply if their health research is applicable to health needs and job shortages of our local community (obesity research, rural health, medical informatics, drug delivery and lab testing, physical therapy, etc.).

These assistantships are available through the generosity of the Portage Health Foundation. They are intended to recognize outstanding PhD talent in health-oriented research areas. Applicants should be a catalyst for promoting and improving the overall health of Houghton, Keweenaw, Baraga, and Ontonagon communities through one of the following:

  • health research and technology development
  • health education or preventive and wellness initiatives
  • rural healthcare access, informatics, and assessment of care

Students who receive full support through a PHF Graduate Assistantship may not accept any other employment. For example, students cannot be fully supported by a PHF Graduate Assistantship and accept support as a GTA or GRA.

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Portage Health Foundation Graduate Assistantship Spring 2019 Recipient – Samerender Nagam Hanumantharao

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Samerender Nagam Hanumantharao
Biomedical Engineering

I received my Master of Science in Biomedical Engineering from Michigan Tech with the thesis titled “A 3D Biomimetic Scaffold using Electrospinning for Tissue Engineering Applications”. Under the guidance of Dr. Smitha Rao, I have continued my research effort in the field of tissue regeneration focusing on biophysical cues in the micro- and nano- scale that impact tissue growth. Tissue regeneration is a complex process that involves a myriad of biological pathways working in tandem. When this harmony is disturbed, it leads to complications which can be fatal. The healing of wounds caused by diabetic foot ulcer is one such disease that prevents complete healing, and involves time-consuming and expensive rehabilitation. My research focuses on identifying the biophysical cues involved in tissue regeneration for wound healing applications and developing a bandage that accelerates the wound healing process using the native cells of the body. The bandage functions by mimicking the physical characteristics of local tissues providing a framework for the cells to attach and proliferate thereby closing the wound.

I look forward to utilizing this opportunity to develop improved scaffolds and enable technologies to enhance our understanding of the various signaling pathways involved in wound healing. I will continue to identify commercial applications and develop my skills both as a researcher and an entrepreneur. The PHF assistantship will be invaluable in my pursuit. I want to thank the Portage Health Foundation, the department of biomedical engineering at Michigan Tech and my advisor Dr. Rao for the help, support and guidance.

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Portage Health Foundation Graduate Assistantship Fall 2019 Recipient – Srinivas Kannan

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Srinivas Kannan
Biomedical Engineering

I began my doctoral research in the Fall of 2016 in the Biomedical Microdevices lab under the guidance of Dr. Smitha Rao. My research is focused on breast cancer and understanding breast cancer cell metastasis using a microfluidic platform. The compromised metabolic processes in breast cancers impact the local tumor environment. This is supported by the enhanced uptake of fructose and expression of GLUT5 (fructose specific transporter membrane proteins) in breast cancer cells compared to healthy cells. The overall objective is to better understand the nutrient microenvironment and impact from the nutrients available in the body on breast cancer, to improve cancer detection and/or therapy. Towards this end, I have contributed by testing the GLUT5 specific fluorescent fructose mimics (ManCou probes) developed in Dr. Tanasova’s lab. My doctoral work also includes developing a three-dimensional in vitro model for understanding cancer microenvironment and metabolic differences, differential uptake of fructose among breast cancer phenotypes and develop a platform for cancer diagnostics.

I thank the Portage Health Foundation for awarding me the assistantship and the department of Biomedical engineering at Michigan tech for the financial support. I am grateful for the continued guidance from my advisor Dr. Smitha Rao and my co-advisor Dr. Marina Tanasova.

 

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Portage Health Foundation Graduate Assistantship Fall 2019 Recipient – Christina Welch

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Christina Welch
Chemistry

In 2015, I joined Dr. Tarun Dam’s lab where the research is centered around Glycobiology. This field of study highlights the importance of glycoproteins in human health. Currently, we are focused on the discovery and characterization of a plant-derived bioactive molecule that has the potential to target pathogenic cells. This molecule can also help in drug delivery processes. In addition, we are studying the biological functions of a prominent heart failure and cancer biomarker.

My experience in Dr. Dam’s lab has been exceptional and I am truly grateful for all of the guidance and growth I’ve received over the years. I would also like to thank the Chemistry department and the graduate school for their never-ending support. I would like to express my deepest gratitude to the Portage Health Foundation, with their help I am able to continue my research with the hope of concluding my research projects soon.

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Spring 2020 PHF Graduate Assistantship Nominations Open

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Applications for spring 2020 PHF Graduate Assistantships are being accepted and are due no later than 4pm, October 22, 2019 to the Graduate School. Instructions on the application and evaluation process are found online. Students are eligible if all of the following criteria are met:

  1. Must be a PhD student participating in health-related research that is aligned with the PHF’s mission.
  2. Must be eligible for or in Research Mode at the time of application.
  3. Must be 2 years after starting the graduate program at the time of application.
  4. Must not be a prior recipient of a PHF Graduate Assistantship.

Priority will be given to students originally from Houghton, Keweenaw, Baraga, or Ontonagon counties. Non-resident students and international students are encouraged to apply if their health research is applicable to health needs and job shortages of our local community (obesity research, rural health, medical informatics, drug delivery and lab testing, physical therapy, etc.).

These assistantships are available through the generosity of the Portage Health Foundation. They are intended to recognize outstanding PhD talent in health-oriented research areas. Applicants should be a catalyst for promoting and improving the overall health of Houghton, Keweenaw, Baraga, and Ontonagon communities through one of the following:

  • health research and technology development
  • health education or preventive and wellness initiatives
  • rural healthcare access, informatics, and assessment of care

Students who receive full support through a PHF Graduate Assistantship may not accept any other employment. For example, students cannot be fully supported by a PHF Graduate Assistantship and accept support as a GTA or GRA.

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Portage Health Foundation Graduate Assistantship Summer 2019 Recipient – Zainab I. Alshoug

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Zainab I. Alshoug
Chemical Engineering

In 2013, I graduated from MTU with a master’s degree under Dr. David Shonnard supervision. My master’s research was on biofuel production. Working with Dr. Shonnard was one of the valuable experiences at MTU. Dr. Shonnard’s research group not only strengthened my research skills but also provided me a hand-on experience of working in a lab.

In order to pursue my aim of getting a doctorate degree in Chemical Engineering, I joined Dr. Adrienne Minerick’s M.D.-ERL research group which provided me an opportunity to work on the design of lab-on-a-chip device to measure the level of lipids in human blood by using different art-of-the-state techniques, such as Liquid chromatography-mass spectrometry (LC-MS). It is a great experience working with Dr. Minerick in many different projects include measuring the effect of consumption of different teas in lipid levels in human blood. She is always a source of encouragement and motivation for me.

I am incredibly grateful for the support of my advisors Dr. Adrienne Minerick, chemical engineering program, and the MTU graduate school. I want to express my deepest gratitude to the Portage Health Foundation, which has supported me to focus on my research and to publish my research in the coming summer. With the help of my advisor Dr. Minerick and the support of the Portage Health Foundation, I will be able to accomplish my publication goals and defend my Ph.D. dissertation by the end of December.

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Portage Health Foundation Graduate Assistantship Summer 2019 Recipient -Bhaskar Halami

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Bhaskar Halami
Chemistry

In the past semesters I have developed procedures and protocols to study the antisense properties of modified DNA strands. Also, I tried my best to develop an oligo anticancer drug mimic. The other graduate students in our lab are continuing the work. The project is most likely to yield great results in coming days. I feel really accomplished as my research is acknowledged by the highly reputed organization like you. The financial assistance included in the award will help me complete my Ph.D. degree in summer 2019. This would not have been possible without a vision of the Portage Health Foundation, an initiative by the Michigan Tech, and the support from my adviser Dr. Shiyue Fang and the chemistry department.

 

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