Category: Research

Unveiling the Journey of Meiling Zhou: Exploring Genetic Variants in Diabetes Research

We are thrilled to announce that Meiling Zhou, a dedicated PhD candidate in Statistics, has been honored with a prestigious $3,000, 12-month grant from the Blue Cross Blue Shield of Michigan Foundation. This grant recognizes her exceptional work and commitment to advancing research in the field of genetics, particularly in detecting genetic variants associated with diabetes. 

First and foremost, I would like to extend my sincere gratitude to the Blue Cross Blue Shield of Michigan Foundation for their invaluable support, acceptance, and acknowledgment.

-Meiling Zhou

A Journey of Passion and Dedication

Meiling’s academic journey started in China with a Bachelor’s and Master’s degree in English Language & Literature with a focus on Cultural Anthropology. Her thirst for knowledge and interdisciplinary exploration led her to earn a second Master’s degree in Applied Statistics and Research Methods from the University of Northern Colorado. Undeterred by challenges, Meiling furthered her education by obtaining a third Master’s in Statistics at Michigan Technological University. Next up, a Ph.D. in Statistics.

Bridging Worlds: From Humanities to Mathematics

Meiling’s transition from the social sciences to the captivating realm of mathematics and genetic statistics reflects her unwavering curiosity and determination. She finds immense satisfaction in the world of research and thinking deeply about statistical methods in human genetics. Her passion lies in developing novel statistical methods that unlock new genetic variants, offering profound insights into the genetic factors contributing to human diseases like Type I diabetes, breast cancer, autism, and more.

Collaborative Excellence: Working with Prof. Kui Zhang

One of the highlights of Meiling’s journey is her collaboration with her advisor, Prof. Kui Zhang. Together, they dive into exciting ideas, navigate challenges, and share moments of laughter and discovery. Meiling attributes much of her growth and joy in research to this quote “Stay Hungry, Stay Foolish” from the famous Steve Jobs speech which was delivered after his cancer diagnosis and successful treatment. 

Embracing Michigan Technological University

For Meiling, Michigan Technological University is not just a place of education but a calling of destiny. Her journey alongside her husband and son has been enriched by the beauty of the campus and the supportive community. From jogging in Daniel Heights to studying in Fisher Hall, every moment has added to her appreciation for this vibrant academic environment.

Inspiring Future Generations

Meiling’s advice to aspiring graduate students resonates with her own journey: “How you start is not always a good indicator of how things turn out. Work hard, fueled by your passion, it is never too late!” Her words encapsulate the essence of perseverance and dedication, encouraging others to pursue their dreams relentlessly.

In Print: Pinelis Paper Published in the Journal Electronic Communications in Probability

Image if Iosif Pinelis who published in the journal electronic communications
Dr. Iosif Pinelis
Professor, Mathematical Sciences

Congratulations to Iosif Pinelis. Dr. Pinelis is the author of a paper published in the Journal Electronic Communications in Probability. The paper is titled “Asymptotics of the rate function in the large deviation principle for sums of independent identically distributed random variables.”

Dr. Pinelis is a professor of mathematical sciences whose main interests are in exact inequalities and limit theorems and extremal problems in probability theory. Other interests include optimization, evolutionary modeling, and operations research.


About the Mathematical Sciences Department

Mathematicians at Michigan Technological University conduct research and guide students, applying concepts to fields like business, engineering, healthcare, and government. The Mathematical Sciences Department offers undergraduate and graduate programs with degrees in mathematical sciences, applied statistics, and statistics. Students supercharge their math skills at Michigan’s premier technological university. They graduate prepared for successful careers in academia, research, and tomorrow’s high-tech business environment.

Questions? Contact us at mathdept@mtu.edu. Follow us on Facebook or read the Mathematical Sciences news blog for the latest happenings.

Ong Closes Contract from Lawrence Livermore National Laboratory

Benjamin Ong
Associate Professor Benjamin Ong

Benjamin Ong is the principal investigator (PI) on a project that has received a $45,000 research and development contract from the Lawrence Livermore National Laboratory, entitled “Systematic Approaches to Construct Coarse-Grid Operators for Multigrid Reduction in Time.”

Multigrid Reduction in Time (MGRIT) [2] uses multigrid reduction techniques to enable temporal parallelism for solving initial value problems. It is known that the convergence rate of MGRIT [3] depends in part on the choice of time-stepping operators on the fine- and coarse-grid, which we call the fine-grid operator and coarse-grid operator respectively. An “ideal” coarse-grid operator is the fine-grid operator applied to approximate the solution on the coarse time interval.

In practice, the ideal coarse-grid operator is never used as the computational cost destroys any parallel speed-up that could be obtained using MGRIT. Instead, a common choice for a coarse-grid operator is a simple re-discretization of the fine-grid operator, i.e., if a single-step method is used on the fine-grid with time-step size h, then the same single-step method is used on the coarse-grid with time-step size m h, where m is a specified coarsening factor.

Numerical simulations are increasingly important in the study of complex systems in engineering, life sciences, medicine, chemistry, physics, and even non-traditional fields such as social sciences. Dr. Ong is working to solve these large-scale evolution problems on modern supercomputing architectures by using a hierarchy of space-time grids to accelerate the solution on the finest time grid.

References

Time permitting, Dr. Ong will explore the connection between the proposed sequences of generated coarse-grid operators to those recently proposed by Vargas et al. [4].

[1] Daniel Crane. The Singular Value Expansion for Compact and Non-Compact Operators. PhD thesis, Michigan Technological University, 2020.

[2] R. D. Falgout, S. Friedhoff, Tz. V. Kolev, S. P. MacLachlan, and J. B. Schroder. Parallel time integration with multigrid. SIAM Journal on Scientific Computing, 36(6):C635–C661, 2014.

[3] Andreas Hessenthaler, Ben S. Southworth, David Nordsletten, Oliver RÅNohrle, Robert D. Falgout, and Jacob B. Schroder. Multilevel convergence analysis of multigrid-reduction-in-time. SIAM Journal on Scientific Computing, 42(2):A771–A796, 2020.

[4] David. A. Vargas. A general framework for deriving coarse grid operators for multigrid reduction in time. Technical report, Lawrence Livermore National Laboratory, 2023.

About the Mathematical Sciences Department

Mathematicians at Michigan Technological University conduct research and guide students, applying concepts to fields like business, engineering, healthcare, and government. The Mathematical Sciences Department offers undergraduate and graduate programs with degrees in mathematical sciences, applied statistics, and statistics. Students supercharge their math skills at Michigan’s premier technological university. They graduate prepared for successful careers in academia, research, and tomorrow’s high-tech business environment.

Questions? Contact us at mathdept@mtu.edu. Follow us on Facebook or read the Mathematical Sciences news blog for the latest happenings.

Applied Mathematics + Computer Engineering = 2x Experiences

Image of Drew Rosales, applied mathematics major at Michigan Tech
Drew Rosales

What to do if you’re a computer engineering major and have plenty of math credits from high school?

If you’re Drew Rosales, you add an applied mathematics major, Blue Marble Enterprise, use your love of coding to help a PhD student conduct his research, and co-op for 10 to 15 hours a week. This Husky knows all about personal and professional exponential growth!
Drew is from Ann Arbor. He chose Michigan Tech because he relished the chance to try something different, get away from his hometown with a few friends, and be more independent. Experience a different part of the world. Drew likes the personable campus and class sizes. “I love the level of bonding here,” he says. “It’s not cutthroat.”

Drew has always enjoyed the engineering process. He’s been competing in Vex Robotics
since middle school, programming and building robots to perform tasks. He’s always been interested in mathematics. Coursework in linear algebra and differential equations helped him to better understand how space and time functions worked and how they relate to the world around us. He found he could use math to describe how objects move through the air and how different variables like drag and torque impact the robots he worked with. The robot improved through increased knowledge of how to manipulate sensor data and control algorithms — a great intersection between math, computer science, and physics. Applied math seemed like a perfect addition to computer engineering. Looking at the influence of mathematical techniques on computer algorithms added excitement to Drew’s studies.

One of his favorite courses is numerical partial differential equations (NPDE). He worked with a group to make a finite element analysis (FEA) tool to create a virtual mesh around a real-world product. The mesh allows the group to use math to show how different forces might impact the product. For example, think about a bridge subject to stressors like winds, tides, and weight-bearing. The tool makes it possible to select the optimal designs and materials for essential project specifications and conditions well before production.

“In NPDE I gained insight into how to use the tool and work with group members. It really was a point at which my two worlds of coding and mathematics (came together).”

Drew Rosales, 2022, double major in applied and computational mathematics and computer engineering

“Research is fun,” says Drew, who’s grateful he’s been able to acquire valuable research experience as an undergrad. He enjoys writing code to support PhD student Praveen Hettige and Professor Ben Ong’s research to find structure in data using Geometric Multi-Resolution Analysis (GMRA). Drew reads academic papers — an art in itself — on GMRA, which is an approach for taking large amounts of high dimensional data and approximating it using affine hyperplanes (think line segments used to approximate a curve) enabling the data to be more easily stored and accessed. He grapples with challenges like creating data representations that can be easily interpreted as well as streamable and applicable to different scientific and engineering domains.

Praveen says Drew is a fast learner who’s up to the task. “In order to complete the coding parts, it’s necessary to have a basic understanding of the theoretical concepts about my research topic,” said the PhD student, who completed his master’s work in statistics at Michigan Tech. “ caught up with those concepts quickly.”

The research is aimed at taking data efficiently in smaller quantities instead of one big dump. Doing so makes it easier to process and analyze the information, reducing computation time and allowing data-based decisions to be made much faster and more efficiently.

Working on Real-World Projects with Michigan Tech Enterprise

Image of Drew Rosales working with the Blue Marble Security Enterprise team
Drew (far left) works with his Blue Marble Security project team


Drew is also a member of Michigan Tech’s Enterprise program, serving as president of Blue Marble Security, a virtual company focused on industry-sponsored R&D and commercial product development including security, the environment, and industrial process control. The team is currently involved in seven multi-disciplinary projects, from smart tow capability for the US Navy to vision sensing for General Motors. In addition to his leadership role, Drew is doing coding and engineering work for the Navy project. Drew’s presidential duties include making sure the teams are progressing in their projects and have the resources they need to be successful. He assists teams in assessing timelines and tasks, is the point person for check-ins with Glen Archer, project sponsors, and keeps the Board informed. “Blue Marble has been instrumental in building my leadership skills. I have to assess how the team is doing and determine how to respond,” Drew says.

Archer goes a bit farther in assessing Drew’s skill. “One of Drew’s strengths that I have come to really appreciate is his calm approach to events around him. He is pretty much imperturbable. Drew is also resolute in his pursuits. He has risen steadily from a project engineer to project manager to the most senior leader in the organization. “

“It’s a pleasure to work with him because I know that if I ask him to do something, he will ask the questions he needs answered in order to do a good job. Once he has the answers, he will not fail to complete the task.”

Glen Archer, Interim Chair, Electrical and Computer Engineering, Blue Marble Security Enterprise Advisor
Image of the Blue Marble Security Enterprise team
Blue Marble Security Enterprise Team, with Drew Rosales standing next to Glen Archer in the lower left.

A Co-op with Caterpillar Builds Skills and Confidence


In addition to classes, research, and Enterprise, Drew works as a co-op student for Caterpillar for 10 to 15 hours per week, a stellar addition to his engineering portfolio. His primary role has been to develop software for engine system sensors and to integrate the sensors into existing software. Drew conducts simulation testing on software for engines, validating that an engine reaches fuel efficiency guidelines and standards. The software allows Caterpillar to validate engine functionality before producing an engine en masse.

The work he’s put into presentation skills during his co-op has built confidence as well as a vision of what a bright future looks like. “I’ve learned more about how a full-time job works, how to work with others in a corporate setting, and what is expected of me on the job,” Drew says. “In addition, I have learned how to prepare myself while in college, building the skill set I need to be successful in my future career.”

Q&A on Drew’s Past, Present, and Future


Q: What have you learned about yourself and what advice would you give your high school self now?

DR: A lot of the time I see myself working on a task that might seem irrelevant or boring and tedious at the time, but it does come together, in the end, to be important. In college, with everything I have done, I’ve gained the ability to think about how to get better. Where are the gaps in knowledge I need to fill in and how do I go about doing it? It goes back to the dualities I’ve encountered between math and engineering, industry, and research. How can I grow and find value out of present and future opportunities? How does this influence what I find interesting and learned thus far?

Before college, I was more shy. Not as well-spoken. I always felt things would come together and fall into my lap. College helped me to see that I needed to be proactive, take initiative and make things happen. That breeds confidence. You would be surprised with the opportunities that you come across through networking, being bold, and sticking to your passions.

Q: Where do you go from here?

DR: I’m switching to a research role this summer doing predictive modeling with autonomous vehicles and possibly putting my GMRA research experience into practice. I plan to continue working at the intersection of math and computer science and putting research into practice. Eventually, I hope to go to graduate school.

2022 Undergraduate Research Symposium

Join us in congratulating Drew Rosales for taking third place!

Undergraduate Research Symposium took place on Friday March 25, 2022 at the Rozsa Lobby. The undergraduate students were able to present posters describing completed or ongoing research, receive feedback from distinguished judges, and learn from the experience.

Drew is double majoring in Computer Engineering and Mathematics. He is research is under supervision of Dr. Benjamin Ong. The presented work entitled “Incremental Geometric Multi-Resolution Analysis”.

What a great experience, and once again congratulations on your hard work!

CTL Instructional Presentation Series: Cécile Piret, 2018 Innovative and Out of Class Teaching Award Recipient

Cecile PiretIn the second presentation of our fall award series, Cécile Piret (Math), will discuss her use of 3-D printing techniques to visualize multivariable functions in teaching Calculus 3, titled “3-D Printing for Mathematics Education.” Her innovative approach has illustrated mathematical concepts that can be studied in unique and practical ways and was recognized as part of the Dean’s Teaching Showcase. Piret will present from 3:30 to 4:30 p.m. Thursday, Oct. 11.

Formal recognition of this award for Innovative and Out of Class Teaching will follow her presentation. Don’t miss this opportunity to learn how you might innovate your own teaching and recognize Cécile’s success. Coffee and light refreshments will be provided to those who register by Monday, Oct 8.