Category: Research

Tayloria Adams—Taking Dielectrophoresis to the Next Level

Tayloria Adams
“I am the first black woman to receive a PhD in chemical engineering at Michigan Tech. I hope this will encourage others!” —Tayloria Adams ‘11 ‘14

Last year the National Science Foundation awarded Michigan Tech alumna Tayloria Adams a prestigious Postdoctoral Research Fellowship in Biology. Adams earned her Master’s and PhD in Chemical Engineering here at Michigan Tech, graduating with nine scholarships, fellowships and awards, three peer-reviewed journal publications, a book chapter, and a patent—No. WO2015051372-A1, to be exact. Her doctoral research examined the dielectric behavior of human mesenchymal stem cells, for the purpose of cell sorting in microfluidic devices.

How did you come to Michigan Tech? 

While on the hunt for a graduate school I was drawn to Michigan for two reasons: my mother lived in Detroit for a while before I was born, and affirmative action was started in the state. I applied to Michigan Tech and scheduled a visit. The environment was very welcoming, which got me hooked! Meeting Dr. Adrienne Minerick during the last year of my master’s degree was icing on the cake. My first interactions with her were in the classroom as I took her Advanced Reactive Systems course. I enjoyed her teaching style. She put a lot of effort into giving meaningful lectures and keeping students engaged. I looked into her research and I was very interested in dielectrophoresis, especially its use in studying red blood cells. The rest is history!

“I am passionate about three things: healthcare-related research, minority student success in STEM, and social justice. These areas are my calling.”

– Tayloria Adams

What was the most challenging aspect of your studies?

Research. There is a huge learning curve when entering a new research field. Learning how to design experiments effectively and accepting that there is no such thing as a perfect experiment are both great challenges. Something will always go wrong, but working through it to still collect the necessary data is what builds character and improves research skills.

What have you done since graduation?

I worked in the Michigan Tech Center for Diversity and Inclusion (CDI) for one year after graduation, as the outreach coordinator. That year gave me the opportunity to grow as a mentor and advocate for underrepresented minority students. I am now conducting postdoctoral research in the Department of Neurology at the University of California, Irvine, in Lisa Flanagan’s lab, studying neural stem and progenitor cells (NSPCs) and their therapeutic potential. NSPCs are desirable because they form the three cell types of the central nervous system, astrocytes, neurons, and oligodendrocytes. However, one challenge is that NSPCs are grown as heterogeneous mixtures and we have little information regarding, which cells are best for neural repair. I’m using dielectrophoresis, an electrokinetic separation technique, as a method to target and enrich specific cells NSPCs. My goal is to effectively sort and characterize them.

You worked hard to educate and engage diverse people about the challenges facing underrepresented students at Michigan Tech. How would you describe the difference you made?

Working at Michigan Tech’s CDI provided me an outlet to engage in important conversations and be a part of the work. CDI was also very supportive of my research. I was able to practice research presentations in the center, use the space as a writing sanctuary when I was completing my dissertation, and almost all of the staff was present at my dissertation defense, which was immensely important to me. One of the best parts of my graduate education is that my daughter Aiyanna experienced college life at the undergraduate and graduate level before reaching college age. She’s learned about important campus resources such as CDI, and I am confident that this exposure has played a part in preparing her for college. As a parent this is something I am very proud of and would consider a success. My greatest frustration was the decline I saw in the number of African American students enrolled at Michigan Tech during my time there. A second frustration is the representation in faculty members. Michigan Tech is a great institution but these are areas where growth would make a huge impact on the community. I would say the difference I’ve made so far is showing what’s possible; but there is much more work to be done.

To learn more about Dr. Adams’s research, visit tayloriaadams.com.

Students Needed for AutoDrive Design Job

AutoDriveThe Electrical, Computer Engineering, and Mechanical Engineering and Engineering Mechanics Departments will hold a community forum at 5 p.m. this Thursday (June 29, 2017) in EERC 100 concerning the AutoDrive Autonomous Vehicle competition.

Michigan Tech is one of eight schools selected to participate in this three year competition. In this forum, we will discuss the high level details concerning the first year of the competition and ways the greater campus community can get involved.

The competition team is also currently looking for motivated students with engineering and software design experience to assist the team on critical design activities during the month of July. Several paid positions are available to exceptionally well-qualified students.

By Jeremy Bos.

Accelerated healing—Understanding physical and chemical cues in tissue repair

Rajachar Research

Rupak Rajachar
Rupak Rajachar
Biomedical Engineering

Made of fibrous connective tissue, tendons attach muscles to bones in the body, transferring force when muscles contract. But tendons are especially prone to tearing. Achilles tendinitis, one of the most common and painful sports injuries, can take months to heal, and injury often recurs.

Michigan Tech researcher Rupak Rajachar is developing a minimally-invasive, injectable hydrogel that can greatly reduce the time it takes for tendon fibers to heal, and heal well.

“To cells in the body, a wound must seem as if a bomb has gone off,” says Rajachar. His novel hydrogel formulation allows tendon tissue to recover organization by restoring the initial cues cells need in order to function. “No wound can go from injured to healed overnight,” he adds. “There is a process.”

Rajachar and his research team seek to better understand that process, looking at both normal and injured tissue to study cell behavior, both in vitro and in vivo with mouse models. The hydrogel they have created combines the synthetic—polyethylene glycol (PEG), and the natural—fibrinogen.

“Cells recognize and like to attach to fibrinogen,” Rajachar explains. “It’s part of the natural wound healing process. It breaks down into products known to calm inflammation in a wound, as well as products that are known to promote new vessel formation. When it comes to healing, routine is better; the familiar is better.”

“To cells in the body, a wound must seem as if a bomb has gone off.”

Rupak Rajachar

The team’s base hydrogel has the capacity to be a therapeutic carrier, too. One formulation delivers low levels of nitric oxide (NO) to cells, a substance that improves wound healing, particularly in tendons. Rajachar combines NO and other active molecules and cells with the hydrogel, testing numerous formulations. “We add them, then image the gel to see if cells are thriving. The process takes place at room temperature, mixed on a lab bench.”

Hydrogel
SEM image of the fibrinogen-based hydrogel

Two commonly prescribed, simple therapies—range of motion exercises that provide mechanical stimulation, and local application of cold/heat—activate NO in the hydrogel, boosting its effectiveness.

“Even a single injection of the PEG-fibrinogen-NO hydrogel could accelerate healing in tendon fibers,” says Rajachar. “ Tendon tissues have a simple healing process that’s easier to access with biomaterials,” he adds. Healing skin, bone, heart, and neural tissue is far more complex. Next up: Rajachar plans to test variations of his hydrogel on skin wounds.

NSF Funds Research and Development on Wearable Electronics

Ye Sun
Ye (Sarah) Sun

Ye (Sarah) Sun (ME-EM/ICC) is the principal investigator on a project that has received a $330,504 research and development grant from the National Science Foundation. Shiyan Hu (ECE) is the Co-PI on the project, “Understanding and Mitigating Triboelectric Artifacts in Wearable Electronics by Synergic Approaches.”

This is a three-year project.

By Sponsored Programs.

Silicon Solar Cell Research in the Journal of Optics

Journal of OpticsAlumni Chenlong Zhang (MSE), Jephias Gwamuri (MSE) and electrical and computer engineering students Sandra Cvetanovic and Mehdi Sadatgol coauthored an article with Durdu Guney (ECE) and Joshua Pearce (MSE/ECE), Enhancement of hydrogenated amorphous silicon solar cells with front-surface hexagonal plasmonic arrays from nanoscale lithography, in the Journal of Optics.

doi.org/10.1088/2040-8986/aa7291

Michigan Tech at Great Lakes Research Conference

Noel Urban and Ashley HendricksThirty-one faculty, staff, undergraduate and graduate students, from Houghton and Ann Arbor, traveled to Detroit from May 15-19. 2017, to attend the 60th International Association of Great Lakes Research (IAGLR) conference at the Cobo Center. Michigan Tech engagement included exhibitor displays staffed by the Great Lakes Research Center (GLRC) and the Michigan Tech Research Institute (MTRI). Michigan Tech was a contributing sponsor made possible by support from the College of Engineering, College of Sciences and Arts, the GLRC and MTRI.

Ashley Hendricks, a graduate student in Environmental Engineering and advised by Dr. Noel Urban (CEE), won the “2017 David M. Dolan Memorial Fellowship” for pursuing graduate research involving modeling and statistics related to the Great Lakes.

Read more at the Great Lakes Research Center blog.

Opportunities in Forest Biomaterials Research

Biomaterials Research
Video: Biomaterials Research

According to Mark Rudnicki, a professor of practice in forest biomaterials at Michigan Technological University, Michigan ranks ninth in the nation in acres of forest cover. It’s also home to several forest-related industries, including forestry and logging, wood products manufacturing and paper manufacturing. In 2013, Michigan Tech initiated the development of a broad coalition – with members from Michigan industry, government and academia – to facilitate the cultivation of new ways to use forest biomaterials.

The initiative has evolved into the Michigan Forest Biomaterials Institute (MiFBI) and Rudnicki is its executive director.

Read more and watch the video at Unscripted: Science and Engineering Research, by Stefanie Sidortsova.

The mission of the Michigan Forest Biomaterials Institute (MiFBI) is to enhance quality of life in Michigan by fostering sustainable forests, communities, and economies through innovative and responsible production, use, and recycling of forest biomaterials.

MIFBI invites individuals and corporate entities (businesses, institutions, associations and government agencies) supportive of developing a forest bioeconomy in Michigan to join MIFBI as a Regular or Associate member.

2017 Research Excellence Funding

ResearchThe Vice President for Research Office announced the 2017 REF awards and thanked the volunteer review committees, as well as the deans and department chairs, for their time spent on this important internal research award process.

Infrastructure Enhancement (IE) Grants
Dan Seguin (MSE/IMP)

Research Seed (RS) Grants
Daisuke Minakata (CEE)
Radwin Askari (GMES/EPSSI)

Portage Health Foundation (PHF) Mid-Career (MC)
CK Choi (MEEM)
Megan Frost (Bio Med)
Jeremy Goldman (Bio Med)

Original article by VPR.

Multi-Dimensional Manufacturing is Best Overall Venture

CMU New Venture Competition

Jim Baker, executive director of Innovation and Industry Engagement and co-director of the Innovation Center for Entrepreneurship, and Lorelle Meadows, dean of the Pavlis Honors College, accompanied students Reggie Dillingham (SBE), Sachin Fernandes (ECE), Joseph Ryan (CS and PSY), Cedric Kennedy (SBE), Kyle Ludwig (ECE), Adam Weber (CNSA), Nick Dubiel (ME), Morgan Crocker (STC), Emily Jensen (SBE) and Brandon Talaska (ChE) who competed in the Central Michigan University New Venture Competition. The competition was held March 24, 2017.

Multi-Dimensional Manufacturing, a 3-D printing technology company founded by Nick Dubiel with support from Morgan Crocker and mentored by Jim Baker finished as the Best Overall Venture with a $30,000 cash prize and a year of mentoring from Blue Water Angels in Midland. The team is also a recent graduate of Michigan Tech’s National Science Foundation I-Corps Site Program.

Three Engineering Students Awarded NSF Graduate Research Fellows

NSFThree students from Michigan Tech have received fellowships from the National Science Foundation’s Graduate Research Fellowship Program (NSF-GRFP), one of the oldest and most competitive programs in the nation. In addition, three students received Honorable Mention, in the prestigious program.

Rebekka Guyon, Mary Kate Mitchell and Roger Guillory II were named GRFP Fellows. Violet Thole, materials research, Kelci Mohrman, physics, and Breeanne Spalding, biomedical engineering, received honorable mention.

Mitchell is an undergraduate chemical engineering major from Plymouth, Michigan who will graduate this spring. Her research focuses on the water-energy nexus, specifically developing more energy efficient methods to remove boron during seawater desalination.

“Current reverse osmosis methods are energy intensive so it is valuable to explore alternative options,” says Mitchell who is appreciative of the prestigious distinction. “I am very grateful to receive this fellowship and want to thank my many mentors I’ve had, throughout my career in industry as well as Michigan Tech.” She says the GRFP will be an invaluable asset to her graduate school career.

Guillory is a biomedical engineering major from Houston, Texas, whose research focuses on evaluating degradable metals (zinc based) for cardiovascular-stent applications. He says the GRFP award is a validation of sorts for the research conducted at Michigan Tech.

“This fellowship proves to me that the work we do here in our labs, and at Michigan Tech have a considerable impact outside of our University and respective disciplines.”

Guyon is a geological engineering major from Detroit. Her research is focused on reducing dust emissions from mine tailings by utilizing bacteria already present within the tailings. Dust emissions impact human health, especially among the Native population where research indicates these dustings have doubled the risk of lung cancer and cause higher incidences of respiratory disease.

“I feel fortunate to receive this prestigious honor,” Guyon says. “Additionally, this is a significant recognition of the mentors, faculty and students that I have worked with over the past few years. Michigan Tech has a very strong intellectual community, so I’m fortunate to conduct my research here.”

Pushpalatha Murthy, dean of Michigan Tech’s Graduate School says, “Being a recipient of the Graduate Research Fellowship or Honorable Mention status in this very prestigious competition speaks to the high caliber of our students and the dedication they have for both intellectual pursuits and serving society. The NSF-GRFP is unique in that it emphasizes commitment to both intellectual inquiry and service to society and are looking to support individuals who have the potential to be high achieving scientists and engineers as well as have a broader impact on society. These awards are a well-deserved recognition of the superior accomplishments of our students and the quality and dedication of Michigan Tech faculty, staff and programs. Crafting a winning proposal is a lot of effort and I want to congratulate the students for their accomplishments and thank the dedication and passion of the faculty and staff who helped them. I look forward to great contributions for our students.”

THE NSF Graduate Research Fellowship Program recognizes and supports outstanding graduate students in NSF-supported science, technology, engineering and mathematics disciplines who are pursing research-based master’s and doctoral degrees at accredited US institutions.

By Mark Wilcox.