Biomedical Engineering Archives | Page 8 of 11

BME Researchers Review Tissue Engineered Vascular Graft Advancements

Published April 30, 2018

TEVG Diagram of blood flow and components — Developing a biocompatible blood-contacting surface remains a major challenge for tissue engineered vascular grafts (TEVGs). This paper reviews the current state of TEVGs with an emphasis on the blood-contacting surface, which includes general vascular physiology and developmental challenges, materials currently employed in TEVGs, and strategies to modify blood-contacting surfaces to resist thrombosis and control cellular recruitment.

Tissue engineered vascular grafts (TEVGs) are beginning to achieve clinical success and hold promise as a source of grafting material when donor grafts are unsuitable or unavailable.

Daniel Radke, Wenkai Jia, Dhavan Sharma, Kemin Fena, Guifang Wang, Jeremy Goldman, and Feng Zhao have a review accepted in Advanced Healthcare Materials. The article “Tissue Engineering at the Blood-Contacting Surface: A Review of Challenges and Strategies in Vascular Graft Development” is an invited review which is a follow-up to a previous research publication: “Aligned nanofibrous cell-derived extracellular matrix for anisotropic vascular graft construction,” Advanced Healthcare Materials. 2017; 6:1601333 (1-6).

This is a timely and comprehensive review article that references extensive publications. It covers significant technological advances regarding tissue engineered vascular grafts for cardiac disease treatment. The review focuses on the challenge of developing a biocompatible blood-contacting surface.

The research group includes faculty, graduate, and undergraduate students in the department.

Ye Sun Develops Convenient Heart Monitor

Published April 12, 2018

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HOUGHTON — According to one study, more than 90 percent of U.S. medical expenses are spent on patients with chronic diseases. According the Center for Disease Control and Prevention, $190 billion are spent on cardiovascular disease that in many cases, patients are required to wear a heart monitor day and night. For those patients, heart monitoring will soon become easier, more comfortable, and more convenient, thanks to Michigan Technological University Researcher Ye (Sarah) Sun.

Biomedical Engineering Students Win at Stryker Engineering Challenge

Published April 12, 2018

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BME Students A team of biomedical engineering students from Michigan Tech took first place in the Eighth Annual Stryker Engineering Challenge competition in Kalamazoo, March 22/23, 2018.

Each team member will receive a $1,000 scholarship and an interview for a Summer 2019 Internship with Stryker Corporation, a medical technology company. Each year Stryker invites engineering student teams to its global headquarters to show off their engineering prowess while competing against rival schools.

During overnight competition, teams spent 12 hours planning, designing, prototyping and testing to prepare for a robotics challenge created by Stryker engineers.

This year, six universities competed. In addition to Tech, teams came from Notre Dame, Western Michigan University, Michigan College Alliance, Purdue and Miami of Ohio.

Michigan Tech was the only biomedical engineering team in the competition. All other teams were comprised of mechanical and electrical engineering students. Undergraduates Becky Daniels, Melanie Thomas, Emil Johnson and Nicholas Turowski made up the Michigan Tech team.

Joe Thompson, associate director, industry engagement in Michigan Tech’s Pavlis Honors College traveled with the students and served as mentor. Biomedical Engineering Associate Department Chair and Professor Keat Ghee Ong is the team’s advisor.

Biomedical Engineering Department Chair Sean Kirkpatrick said “Last year was BME’s first year in the Stryker competition and we took second place. This year’s first-place finish shows last year wasn’t a fluke—Michigan Tech BME students are very capable engineering students who can handily solve classical engineering problems.”

Thompson adds, “The event organizers at Stryker made a point of highlighting the professionalism displayed by Michigan Tech team. The ability to adapt to changing circumstances and collectively persevere contributed to the team’s success this year.”

Michigan Tech's robot at the 2018 Stryker Engineering Challenge — Michigan Tech’s robot at the Eighth Annual Stryker Engineering Challenge in Kalamazoo, Michigan

The first half of the competition involved picking up small Lego people with the robot and transporting them to the team’s ‘pit stop’. The team was able to deliver a ‘VIP passenger’ to gain extra points, but then their robot arm malfunctioned, sinking them from 1st place to 4th place as a result. The second half of the competition involved an actual race throughout the course. Michigan Tech’s robot had the fastest time.

“It was exciting to see how our ideas came to life, and how prototypes became the actual parts that contributed to our victory,” says Thomas. “It was a constant reminder of why we chose to pursue engineering.”

“The best feelings came whenever a team member was stuck with a particular problem and another team member’s suggestion turned out to be the working solution. During the competition we learned how to work with nearly complete strangers. We adapted once we figured out each other’s strengths,” says Johnson.

“Throughout the challenge we all provided whatever insight we could if we noticed someone struggling with a task, and it was always without judgement,” adds Daniels.

“Every employee at Stryker seemed to love their job,” notes Turowski. “One told about how during his first year at Stryker he was put on a team of ‘vets’ and asked to complete a task that had never before been done. I think that shows how much confidence Stryker has in its employees.”

“You don’t have to know the people you’re working with for a very long time in order to be an effective team. You just need to set your eyes on a collective goal and work to successfully complete it.

– Melanie Thomas

Stryker Corporation, active in more than 100 countries, is one of the world’s leading medical technology companies, offering products and services to help improve patient and hospital outcomes.

Michigan Tech BME students Emil Johnson, Nicholas Turowski, Melanie Thomas, and Becky Daniels along with mentor Joe Thompson at the 2018 Stryker Engineering Challenge, where they took first place. — Michigan Tech BME students Emil Johnson, Nicholas Turowski, Melanie Thomas, and Becky Daniels along with mentor Joe Thompson at the 8th Annual Stryker Engineering Challenge, where they took first place.

2018 Portage Health Foundation Making a Difference Scholarship Recipients

Published April 9, 2018

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Twelve students have been awarded the Portage Health Foundation Making a Difference Scholarship. The scholarships are part of a Michigan Tech-Portage Health Foundation partnership established in 2015 to support health education. This year’s recipients have an average GPA of 3.87 and represent the breadth of health-related research happening on Michigan Tech’s campus.

The $8,000 scholarships went to:

Bailey Poyhonen, Dollar Bay, medical laboratory science
Brennah Wasie, Hancock, biochemistry and molecular biology
Laura Lyons, Lake Linden, biomedical engineering
Sarah Dix, L’Anse, exercise science

Receiving $1,000 scholarships were:

Kierstyn Codere, Lake Linden, biological sciences
Grace Liu, Houghton mechanical engineering
Mara Hackman, Houghton, medical laboratory science.
Jaden Janke, Dollar Bay, biological sciences
Ally Fenton, Hancock, biomedical engineering
Jada Markham, Houghton, exercise science
Kellan Heikkila, Chassell, biomedical engineering
Dawson Kero, Hancock, biological sciences

“The merit-based awards reflect the high caliber student talent we have locally, thanks to exceptional teachers, HOSA high school advisers, and Michigan Tech faculty and students who do outreach in the schools,” says Jodi Lehman, director of foundations at Michigan Tech.

At a dinner for finalists, the scholarship recipients had a chance to talk one-on-one with Michigan Tech researchers. Mechanical Engineering-Engineering Mechanics faculty Ye Sarah Sun shared with students how she develops new interfaces for heart monitoring that are reliable and won’t disturb a patient’s life at home, while driving or at work.

Biomedical engineer and health care entrepreneur, Megan Frost, shared how she is working to improve wound care with a product designed to prevent infection and reduce the need for some post-acute care.

Scholarship recipients also heard from current students, Adison Cook, a 2016 Making a Difference scholar; Stephanie Bean and Maddie Morley, both PHF Undergraduate Research Interns; and Kelsey Saladin, a Portage Health Foundation and Randy Owsley Memorial Athletic trainer scholar.

“The Portage Health Foundation has also been very generous in granting need-based scholarships to students enrolling at Michigan Tech, Finlandia University, Gogebic College, Northern Michigan University, and Michigan State University in health-related degree programs,” says Joe Cooper, Director of Financial Aid at Michigan Tech, “These scholarships make a significant financial impact for students in our own local communities. Thanks to the Portage Health Foundation, students from Baraga, Houghton, Keweenaw, and Ontonagon counties have extra support so they can attend college and focus on health related careers.”

Portage Health Foundation Making a Difference Scholarship applications will open in the fall for incoming high school seniors and transfer students applying to Michigan Tech for fall 2019. Questions about the scholarship can be directed to Rachel Connors, assistant director of admissions, 7-1880.

By Foundation Relations.

2018 SURF Award Recipients in Engineering

Published April 3, 2018

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The Summer Undergraduate Research Fellowship (SURF) program will fund 25 students from across the University with funds from the office of the Pavlis Honors College and the Vice President for Research.

Previous SURF award recipients have included Goldwater Scholarship and NSF Graduate Research Fellowship recipients. Since 2002, SURF students have co-authored 78 peer reviewed publications.

This year’s recipients, project titles, and advisors are listed online.

Honorable Mention went to Kiaya Caspers, Travis Durgan, Elisha Earley and Ashley Lingle.

By Will Cantrell.

Biomedical Engineering Majors

Stephanie Jewell
Biomedical Engineering / Mechanical
William Cook / KIP
Controlled Breathing and Automatic Cardiovascular Control

Kaylee Meyers
Rupak Rajachar / Biomedical Engineering
Evaluating the Influence of Matrix Stiffness on the Activation of MMPs in Tendinopathy

Alexander Oliver
Jeremy Goldman / Biomedical Engineering
Characterizing the Inflammatory Response to Zinc Stent Materials

Brennan Vogl
Smitha Rao / Biomedical Engineering
Monitoring migration of cancer cells using a microfluidic device

Chemical Engineering Major

Satyen Dhamankar
Chemical Engineering / Mathematics
Benjamin Ong / Mathematical Sciences
Accelerated Boundary Integral Methods

Civil Engineering Major

Timothy Stone
Don Lafreniere / Social Sciences
Exploring the Social Determinants of health and Disease Outbreak Patterns in Children in Early Twentieth Century Calumet

Geological Engineering Major

Katelyn Kring
Snehamoy Chatterjee / GMES
Spatial Interpolation of Rock Quality Designation to Design Underground Support System for Eagle Mine

Mechanical Engineering Majors

Dennis J Byard
Joshua Pearce / Materials Science
Increasing Maker Manufacturing through 3D Printing with Reclaimed Plastic & Direct Drive Pellet Extrusion

Aaron Dean
Pasi Lautala / Civil and Environmental Engineering
Using Naturalistic Driving Data and Machine Learning to Predict Accident Risk at Highway-Rail Grade Crossings

Eric Houck
Mo Rastgaar / Mechanical Engineering
Magneto-Rheological Fluids Create a Natural Walking Gait in Ankle-Foot Prostheses

David Ross and Alex Baker Place in Undergraduate Research Symposium 2018

Published March 28, 2018

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The Pavlis Honors College (PHC) announces the winners of the sixth Annual Undergraduate Research Symposium.

The students that presented this year represented a wide array of scientific and engineering disciplines from across campus and highlighted the diversity of research areas being explored. Judges from a variety of backgrounds and disciplines volunteered their time to evaluate participant posters and presentations. The results were as follows:

First Place: Erinn Smith, Chemistry
Second Place: David Ross, Biomedical Engineering
Third Place: Alex Baker, Civil and Environmental Engineering

David Ross presented Bioactive polydimethylsiloxane surface for optimal human
mesenchymal stem cell sheet culture. Ross’ advisor is Feng Zhao.

Alex Baker presented Multiobjective Optimization of Cost and Strength for Various
Lengths of Doubly Reinforced Concrete T-beams. Baker’s advisor is Amlan Mukherjee.

PHC would also like to recognize three students in the Honorable Mention category: Benjamin Miller, SFRES, Rose Turner, Environmental Engineering and Hannah Cunningham, Molecular Biology and Genetics.

The research presented here is sponsored in part by the Office of the Vice President of
Research, the Portage Health Foundation (PHFoundation), the Pavlis Honors College, and the Summer Undergraduate Research Fellowship (SURF) program.

Congratulations to all of our winners and honorable mentions. Thank you to all of the faculty, staff and students that judged and attended the Symposium this year.

Original story by Pavlis Honors College.

2018-19 Michigan Space Grant Consortium Awards

Published March 8, 2018

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Michigan Tech faculty, staff and students received awards tallying $73,675 in funding through the Michigan Space Grant Consortium (MSGC), sponsored by NASA for the 2018-19 funding cycle.

Engineering undergraduates receiving $2,500 research fellowships:

Alex Oliver (BME): “Evaluating Biodegradeable Zinc Stent Materials,” with Jeremy Goldman
Katie Bristol (Applied Geophysics): “Investigation of the Solar Nebula’s Magnetic Field Strength from the Allende Meteorite Chondrules,” with Aleksey Smirnov

Engineering graduate Students receiving $5,000 research fellowships:

Erica Coscarelli (CEE): “Reaction Mechanisms for the Degradation of Trace Organic Contaminants through Advanced Oxidation Processes,” with Daisuke Minakata
Sanna Mairet (GME): “Investigating the Relationship between Volcanic Sulfur Dioxide Concentrations and Human Population and Land Use Changes through Geographic Visualization,” with Simon Carn
Brandi Petryk (GME): “The Origin of an Archean Batholith – Michigan’s Upper Peninsula,” with Chad Deering
Emily Shaw (CEE): “Mapping the Co-Distribution of Mercury and Polychlorinated Biphenyls (PCBs) in Michigan’s Upper Peninsula Lakes,” with Noel Urban

Engineering faculty and staff members receiving $5,000 or more for pre-college, public outreach, teacher training, faculty seed and/or augmentation programs include:

Joan Chadde (CEE): “STEM Career Explorations for Detroit High School Students” (includes augmentation) Pre-college program
Brian Doughty (CEE): “Technology and Outdoor Learning” Pre-college program
Adrienne Minerick (COE): “Microfluidic Dynamic Cell Concentration Tuner for Medical Diagnostics” Faculty Seed Program

NASA implemented the National Space Grant College and Fellowship Program in 1989 to provide funding for research, education and public outreach in space-related science and technology. The program has 52 university-based consortia in the United States and Puerto Rico.

As an affiliate of the Michigan Consortium, Michigan Tech has been an active participant in MSGC for approximately 20 years. MSGC funding is administered through MTU’s Pavlis Honors College. For more information, contact Paige Hackney in the Pavlis Honors College, call 7-4371, or visit the MSGC website.

Original story by Pavlis Honors College.

Invent It Build It: Six Questions with Hannah Cunningham

Published March 7, 2018

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Hannah Cunningham '18 BME, pictured here in the colored-glass walkway at the Aros Art Museum in Denmark. Credit: Taran Schatz — Hannah Cunningham ’18 BME, pictured here in the colored-glass walkway at the Aros Art Museum in Denmark. Credit: Taran Schatz

Hannah Cunningham, a senior majoring in biomedical engineering at Michigan Tech, has been working with kids since she was in high school. Volunteering several times at the Society of Women Engineers’ annual Invent it Build It event for middle school girls was a natural thing for her to do. She took part while attending SWE conferences in Nashville, Philadelphia, and most recently at the National SWE WE17 Conference in Austin, Texas.

Q: What’s it like to volunteer for Invent It Build It?
A: I’ve had a few different roles. I’ve worked directly with the girls as a table leader, I’ve staged materials during the event, and been a “floater” who simply fills in where help is needed with things like registration, grabbing forgotten supplies from the hotel, or pouring oil into cups.

I had the greatest interaction with the girls as a table leader. My primary job was to direct my table of four or five girls through the two activities during the day, while making sure they were thinking critically about the engineering challenge and developing their engineering skills. Luckily, they were middle schoolers, so it was easy to talk with them and learn more about them.

Q: Do you see yourself in any of the participants?
A: The girls who attend are local to the city where the conference is being held. For the most part they’re very similar. They don’t really have any idea what they want to do, but engineering could be their future. At the event they work together on engineering challenges with varying levels of teamwork, but all are capable of providing something to the challenge.

At that age it can be difficult to see your own contribution. It’s even more difficult to respect your own work without comparing it to everyone else’s. This event gives them a chance to build one thing as a team, with each participating in some way.

I try not to remember myself as a middle schooler, but some of the girls definitely remind me of myself. When faced with the project/challenge, they work at it, and work hard, until they’ve come to final product.

Q: Are you involved in any other engineering outreach?
A: While at Michigan Tech I have taught various courses for first and second graders through the Center for Science and Environmental Outreach led by Joan Chadde-Schumaker. When I teach these classes, even if the topic is not related to engineering, such as wildlife exploration, I always make sure to develop a project to include engineering. I believe engineering projects challenge kids’ creativity, teamwork skills and technical skills. Engineering projects are fantastic for any classroom setting and the supplies can be simple, recyclable materials.

Q: What would you like to do when you graduate?
A: I am due to graduate with a BS in biomedical engineering this Spring (!). I plan to pursue an accelerated master’s degree in Kinesiology next year. I wan to finish my research and learn more about biomechanics. I’d like to become involved in a company or university that will allow me to develop and/or research products that can be beneficial for human health. I’m interested in biomechanics, so anything dealing with treating, modifying, or enhancing human movement is fair game.

Q: How has being involved with SWE impacted your life so far?
A: I’ve learned about the many different roles women can have in engineering. SWE has helped me develop my skills as a professional, by offering networking events with professionals and businesses. My own educational path has slowly directed me away from engineering, but I still feel strongly that I can still be involved even if my job title isn’t “engineer”.

Accelerated healing—Understanding physical and chemical cues in tissue repair

Published June 16, 2017

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Rajachar Research

Made of fibrous connective tissue, tendons attach muscles to bones in the body, transferring force when muscles contract. But tendons are especially prone to tearing. Achilles tendinitis, one of the most common and painful sports injuries, can take months to heal, and injury often recurs.

Michigan Tech researcher Rupak Rajachar is developing a minimally-invasive, injectable hydrogel that can greatly reduce the time it takes for tendon fibers to heal, and heal well.

“To cells in the body, a wound must seem as if a bomb has gone off,” says Rajachar. His novel hydrogel formulation allows tendon tissue to recover organization by restoring the initial cues cells need in order to function. “No wound can go from injured to healed overnight,” he adds. “There is a process.”

Rajachar and his research team seek to better understand that process, looking at both normal and injured tissue to study cell behavior, both in vitro and in vivo with mouse models. The hydrogel they have created combines the synthetic—polyethylene glycol (PEG), and the natural—fibrinogen.

“Cells recognize and like to attach to fibrinogen,” Rajachar explains. “It’s part of the natural wound healing process. It breaks down into products known to calm inflammation in a wound, as well as products that are known to promote new vessel formation. When it comes to healing, routine is better; the familiar is better.”

“To cells in the body, a wound must seem as if a bomb has gone off.”

– Rupak Rajachar

The team’s base hydrogel has the capacity to be a therapeutic carrier, too. One formulation delivers low levels of nitric oxide (NO) to cells, a substance that improves wound healing, particularly in tendons. Rajachar combines NO and other active molecules and cells with the hydrogel, testing numerous formulations. “We add them, then image the gel to see if cells are thriving. The process takes place at room temperature, mixed on a lab bench.”

Two commonly prescribed, simple therapies—range of motion exercises that provide mechanical stimulation, and local application of cold/heat—activate NO in the hydrogel, boosting its effectiveness.

“Even a single injection of the PEG-fibrinogen-NO hydrogel could accelerate healing in tendon fibers,” says Rajachar. “ Tendon tissues have a simple healing process that’s easier to access with biomaterials,” he adds. Healing skin, bone, heart, and neural tissue is far more complex. Next up: Rajachar plans to test variations of his hydrogel on skin wounds.

2017 Research Excellence Funding

Published April 28, 2017

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The Vice President for Research Office announced the 2017 REF awards and thanked the volunteer review committees, as well as the deans and department chairs, for their time spent on this important internal research award process.

Infrastructure Enhancement (IE) Grants
Dan Seguin (MSE/IMP)

Research Seed (RS) Grants
Daisuke Minakata (CEE)
Radwin Askari (GMES/EPSSI)

Portage Health Foundation (PHF) Mid-Career (MC)
CK Choi (MEEM)
Megan Frost (Bio Med)
Jeremy Goldman (Bio Med)

Original article by VPR.

Category: Biomedical Engineering

Engineering undergraduates receiving $2,500 research fellowships:

Engineering graduate Students receiving $5,000 research fellowships:

Engineering faculty and staff members receiving $5,000 or more for pre-college, public outreach, teacher training, faculty seed and/or augmentation programs include:

“To cells in the body, a wound must seem as if a bomb has gone off.”