Category: ME-EM

MS Defense: Vijay Pathak

by Mechanical Engineering

Vijay Pathak (advisor Ghosh Susantra) a master’s in Mechanical Engineering student will present his master’s defense at 2 p.m. tomorrow (April 14) via Zoom.

The title of the presentation is “Studying the Effects of Initial Crack Angle on the Crack Propagation in Graphene Nano-Ribbon Through Molecular Dynamics Simulations.”

Get to Know Dr. Sangyoon Han, Biomedical Engineering

Dr. Sangyoon Han is an assistant professor in Michigan Tech’s Biomedical Engineering department, and an affiliated assistant professor in the Mechanical Engineering-Engineering Mechanics department. He is also advisor to the Korean Students Association. He has been with Michigan Tech since 2017.

Han recently joined the Institute of Computing and Cybersystems and its Data Sciences research group. His primary research interests are in mechanobiology, cell migration, and image data modeling. His research goals include applying computer vision to microscopic images to capture meaningful information, and he’s looking for collaborators.

“Anyone with a good machine learning background is encouraged to contact me to discuss potential research,” he says. “Also, students who learned assignment problems or particle tracking are encouraged to contact me to discuss potential tracking-related projects.”

Teaching and Mentoring

Han’s teaching interests include computer vision for microscopic images, fluid mechanics, cell biomechanics and mechanobiology, and soft tissue mechanics. This academic year, he instructed Computer Vision for Microscopic Images in the Fall semester, and Fluid Mechanics this Spring.

Han enjoys teaching and interacting with students, “and feel their energy, too.” He says he makes a deliberate effort in his classes to pause from time to time so that his students can ask questions.

Han advises two Biomedical Engineering Ph.D. students, Nikhil Mittal and Mohanish Chandurkar.

“Nik is working on finding myosin-independent mechanosensitivity mechanism for stiffness sensing, and Mohanish works on the project finding mechano-transmission for fluid shear stress sensing by endothelial cells,” he says.

Research Aspirations

Han’s Mechanobiology Lab is interested in finding fundamental mechanisms governing mechanotransduction, and how cells sense mechanical forces and convert them into biochemical signals.

“We image cells and associated forces using high-resolution live imaging, which we analyze to obtain statistically meaningful quantity of data,” Han explains. “We apply force-measuring and molecular-imaging/analysis technologies for stiffness sensing, shear flow sensing, adhesion assembly, and cancer mechanobiology.”

Han is working to gain a thorough understanding of the mechano-chemical interaction between cancer cells and their microenvironment, and develop a an effective mechano-therapeutic strategy to stop the progression of cancer, and breast cancer in particular. Ultimately, he wants to apply that knowledge to cancer mechanobiology

Han is principal investigator of a three-year NIH/NIGMS research project, “Nascent Adhesion-Based Mechano-transmission for Extracellular Matrix Stiffness Sensing.” The research aims to determine whether newly-born adhesions can sense tissue stiffness through the accurate measurement of the mechanical force and molecular recruitment of early adhesion proteins.

Some Background

In 2012, Han received his Ph.D. in Mechanical Engineering from the University of Washington in the areas of cell mechanics, multiphysics modeling, and bioMEMS.

For his postdoctoral training, he joined the Computational Cell Biology lab led by Dr. Gaudenz Danuser in the Cell Biology department of Harvard Medical School. In 2014, he joined the UT Southwestern (University of Texas) Department of Cell Biology and Bioinformatics. Han received his B.S and M.S. degrees in mechanical engineering at Seoul National University, Korea, in 2002 and 2004, respectively.

Han holds several patents and in 2015, he developed an open-source TFM (Traction Force Microscopy) Package, which is shared via his lab’s website:

Beyond Research and Teaching

Han loves science and discovering something new in his research investigations. Beyond his work as a professor and scientist, he describes himself as a husband to Sunny, and a dad to his son, Caleb.

“I am just a normal Korean who likes singing and dancing,” he says. “Unfortunately, my voice is still recovering from surgery, but I hope to get back to it soon. I also like to listen to all kinds of music, including hip-hop, classics, and pop.”

He appreciates a good sense of humor, but he says that being humorous in American English is something he continues to learn.

Han says he tries to be “normal” and not too nerd-like when he’s not pursuing his research, but “there are times when I am making my own hypothesis about some phenomena I observe in my daily life.”

Han enjoys life at Michigan Tech and in the Cooper Country. He likes getting to know his energetic students and he finds Michigan Tech faculty members very strong and collegial. He also enjoys the snow, hockey, and the mountains.

“I really like the snow here. I am already sad that the weather is becoming too mild!” he confirms. “It’s also a safe environment to raise kids, which is a big plus.”

And he likes his academic department. “Everyone is so nice in the Biomedical Engineering program, they have been so welcoming and appreciative my research,” Han says. “It’s a family-like environment.”

Active Research

1R15GM135806-01 (09/16/2019 – 08/31/2022)

Funding Agency: NIH/NIGMS

Nascent Adhesion-Based Mechano-transmission for Extracellular Matrix Stiffness Sensing

Project Goals: To determine whether newly-born adhesions can sense tissue stiffness by accurate measurement of mechanical force and of molecular recruitment of early adhesion proteins using traction force microscopy and computer vision techniques.
Role: Principal Investigator

Additional Information

The Mechanobiology Lab studies mechanobiology, particularly how adherent cells can sense and respond to mechanical stiffness of the extracellular matrix. To investigate this, the lab has established experimental and computational frameworks for force measurement and adhesion dynamics quantification. Researchers apply these frameworks, with cutting edge computer vision technique, on live-cell microscope images to investigate the fundamental mechanism underlying mechanosensation in normal cells, and the biomechanical signature of the diseased cells whose signaling has gone awry.

The Institute of Computing and Cybersystems (ICC) creates and supports an arena in which faculty and students work collaboratively across organizational boundaries in an environment that mirrors contemporary technological innovation. The ICC’s 60+ members, in six research centers, represent more than 20 academic disciplines at Michigan Tech.

The ICC Center for Data Sciences (DataS) focuses on the research of data sciences education, algorithms, mathematics, and applications.

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives.

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention.

Recent Publications

  • Han, S. J.; Azarova, E. V.; Whitewood, A. J.; Bachir, A.; Guttierrez, E.; Groisman, A.; Horwitz, A. R.; Goult, B. T.; Dean, K. M.; Danuser, G. Pre-Complexation of Talin and Vinculin without Tension Is Required for Efficient Nascent Adhesion Maturation. eLife 2021, 10, e66151.
  • Schäfer, C., Ju, Y., Tak, Y., Han, S.J., Tan, E., Shay, J.W., Danuser, G., Holmqvist, M., Bubley, G. (2020) TRA-1-60-positive cells found in the peripheral blood of prostate cancer patients correlate with metastatic disease. Heliyon 6(1), e03263.
  • Isogai, T., Dean, K.M., Roudot, P., Shao, Q., Cillay, J.D., Welf, E.S., Driscoll, M.K., Royer, S.P., Mittal, N., Chang, B., Han, S.J., Fiolka, R., Danuser, G., Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D, BioRxiv, 2019
  • Mohan, A.S., Dean, K.M., Isogai, T., Kasitinon, S.Y., Murali, V.S., Roudot, P., Groisman, A., Reed, D.K., Welf, E.S., Han, S.J., Noh, J., and Danuser, G. (2019). Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Developmental Cell, 49(3), pp.444-460.
  • Manifacier I., Milan, J., Beussman, K., Han, S.J., Sniadecki, N.J., About, I (2019) The consequence of large-scale rigidity on actin network tension. In press. Comp Meth Biomech Biomed Eng, 2019 Oct;22(13):1073-1082.
  • Costigliola, N., Ding, L., Burckhardt, C.J., Han, S.J., Gutierrez, E., Mota, A., Groisman, A., Mitchison, T.J., and Danuser, G. (2017) Vimentin directs traction stress. PNAS2017 114 (20) 5195-5200.
  • Han, S.J., Rodriguez M.L., Al-Rekabi, Z., Sniadecki, N.J. (2016) Spatial and Temporal Coordination of Traction Forces in One-Dimensional Cell Migration, Cell Adhesion & Migration. 10(5): 529-539.
  • Oudin, M.J., Barbier, L., Schäfer, C, Kosciuk, T., Miller, M.A., Han, S.J., Jonas, O., Lauffenburger, D.A., Gertler, F.B. (2016) Mena confers resistance to Paclitaxel in triple-negative breast cancer. Mol Cancer Ther.DOI: 10.1158/1535-7163. MCT-16-0413. 
  • Milan,J., Manifacier, I., Beussman, K.M., Han, S.J., Sniadecki, N.J., About, I., Chabrand, P. (2016) In silico CDM model sheds light on force transmission in cell from focal adhesions to nucleus. J Biomechanics. 49(13):2625-2634. 
  • Lomakin. A.J., Lee, K.C., Han, S.J., Bui, A., Davidson, M., Mogilner, A., Danuser G. (2015) Competition for molecular resources among two structurally distinct actin networks defines a bistable switch for cell polarization, Nature Cell Biology. 17, 1435–1445
  • Han, S.J., Oak, Y., Groisman, A., Danuser, G. (2015) Traction Microscopy to Identify Force Modulation in Sub-resolution Adhesions, Nature Methods. 12(7): 653–656

1010 with Jung Bae, Applied Computing, ME-EM

You are invited to spend one-zero-one-zero—that is, ten—minutes with Dr. Jung Yun Bae on Thursday, April 1, from 4:30 to 4:40 p.m. EST.

Dr. Bae is an Assistant Professor in the Applied Computing and Mechanical Engineering-Engineering Mechanics departments.

She will discuss her research, the Applied Computing department, and answer questions.

Dr. Bae earned her Ph.D. in Mechanical Engineering at Texas A&M University and worked as a research professor at Korea University before she joined Michigan Tech.

Dr. Bae’s research interests include:

  • Robotics, Multi-robot systems
  • Coordination of Heterogeneous Robot Systems
  • Vehicle Routing Problems
  • Multi-robot System Control and Optimization
  • Autonomous Navigation
  • Unmanned Vehicles
  • Operational Research for Autonomous Vehicles

We look forward to spending 1010 minutes with you!

Visit the 1010 with … webpage here.

Susanta Ghosh Publishes Paper in APS Physical Review B Journal

Assistant Professor Susanta Ghosh, ME-EM, has published the article, “Interpretable machine learning model for the deformation of multiwalled carbon nanotubes,” in the APS publication, Physical Review B.

Co-authors of the paper are Upendra Yadav and Shashank Pathrudkar. The article was published January 11, 2021.

Ghosh is a member of the Institute of Computing and Cybersystems’ Center for Data Sciences.

Article Abstract

In the paper, researchers present an interpretable machine learning model to predict accurately the complex rippling deformations of multiwalled carbon nanotubes made of millions of atoms. Atomistic-physics-based models are accurate but computationally prohibitive for such large systems. To overcome this bottleneck, we have developed a machine learning model. The proposed model accurately matches an atomistic-physics-based model whereas being orders of magnitude faster. It extracts universally dominant patterns of deformation in an unsupervised manner. These patterns are comprehensible and explain how the model predicts yielding interpretability. The proposed model can form a basis for an exploration of machine learning toward the mechanics of one- and two-dimensional materials.

APS Physics advances and diffuses the knowledge of physics for the benefit of humanity, promote physics, and serve the broader physics community.

Physical Review B (PRB) is the world’s largest dedicated physics journal, publishing approximately 100 new, high-quality papers each week. The most highly cited journal in condensed matter physics, PRB provides outstanding depth and breadth of coverage, combined with unrivaled context and background for ongoing research by scientists worldwide.

Sun Named to Lou and Herbert Wacker Professorship in Mechanical Engineering

by Office of the Provost & Senior VP for Academic Affairs

Ye “Sarah” Sun (ME-EM) has accepted the Lou and Herbert Wacker Professorship in Mechanical Engineering, which was created to retain and attract high-quality faculty who are at the top of their profession, can excite students to think beyond the classroom material, and knows how to integrate their research into the classroom.

Sun was chosen for this position as she is recognized as a rising star and outstanding researcher in the area of wearable sensors, systems, and robotics and a respected member of the smart health community.

In recognition of her innovative research in wearable sensors, Sun’s NSF CAREER award was selected for presentation to congressional offices in April 2019.

Sun is the director of the Institute of Computing and Cybersystems’s Center for Cyber-Physical Systems.

Among her research honors is the prestigious National Science Foundation (NSF) CAREER Research Award on “System-on-Cloth: A Cloud Manufacturing Framework for Embroidered Wearable Electronics.”

Sun will use this recognition and support to enhance her research in wearable and soft robotics. Her goal is to develop flexible textile robotics by leveraging the physical understanding and modeling of textile materials and dynamics and the recent advances of morphological computing.

Textile robotics are not only able to enhance human capabilities via wearable design but also achieve autonomous locomotion. The controllable structures of textiles directly provide a unified platform that is capable of integrating sensing and actuating into textile robotics itself. The positioning support will be used to recruit graduate students and to set up the manufacturing platform.

Sarah Sun to Present ME-EM Graduate Seminar Dec. 3, 4 pm

by Mechanical Engineering – Engineering Mechanics

The next virtual Graduate Seminar Speaker will be held at 4 p.m. tomorrow (Dec. 3) via Zoom. Sarah Sun (ME-EM) will present “E-Logo: Embroidered Wearable Electronics.”

Sun is an associate professor in the Department of Mechanical Engineering-Engineering Mechanics and an affiliated associate professor in the Department of Biomedical Engineering at Michigan Tech since 2014.

Research Excellence Fund Awards Announced

by Vice President for Research Office

The Vice President for Research Office announces the Fall 2020 REF awards. Thanks to the individual REF reviewers and the REF review panelists, as well as the deans and department chairs, for their time spent on this important internal research award process.

Research Seed Grants:

  • Sajjad Bigham, Mechanical Engineering-Engineering Mechanics
  • Bo Chen, Computer Science
  • Daniel Dowden, Civil and Environmental Engineering
  • Ana Dyreson, Mechanical Engineering-Engineering Mechanics
  • Hassan Masoud, Mechanical Engineering-Engineering Mechanics
  • Xinyu Ye, Civil and Environmental Engineering

Sangyoon Han to Present Chemistry Seminar this Friday, Nov. 13, at 3 pm

A Chemistry Seminar will be presented Friday, September 13, 2020, at 3:00 p.m., via online meeting.

Dr. Sangyoon Han will present his lecture, “Toward Discovery of the Initial Stiffness-Sensing Mechanism by Adherent Cells.” Han is an Assistant Professor in Biomedical Engineering, an Affiliate Assistant Professor in Mechanical Engineering-Engineering Mechanics, and advisor for the Korean Student Association. Han is a member of the ICC’s Center for Data Science.

Lecture Abstract

The stiffness of the extracellular matrix (ECM) determines nearly every aspect of cellular/tissue development and contributes to metastasis of cancer. Adherent cells’ stiffness-sensing of the ECM triggers intracellular signaling that can affect proliferation, differentiation, and migration of the cells. However, biomechanical and molecular mechanisms behind this stiffness sensing have been largely unclear. One critical early event during the stiff-sensing is believed to be a force transmission through integrin-based adhesions, changing the molecular conformation of the molecules comprising the adhesions that link the ECM to the cytoskeleton. To understand this force transmission, my lab develops experimental and computational techniques, which include soft-gel-based substrates, live-cell imaging, computer-vision-based analysis, and inverse mechanics, etc. In this talk, I will talk about how we use soft-gel to quantify the spatial distribution of mechanical force transmitted by a cell, how we use light microscopy and computer vision to analyze the focal adhesions, and how these techniques are related to stiffness sensing. In particular, I will show you new data where cells can transmit different levels of traction forces in response to varying stiffness, even when the activity of the major motor protein, myosin, is inhibited. At the end of the talk, potential molecules responsible for the differential transmission will be discussed. 

Researcher Bio

Sangyoon Han received his Ph.D. in Mechanical Engineering at the University of Washington (UW) in 2012 and did postdoctoral training with Dr. Gaudenz Danuser in the Department of Cell Biology at Harvard Medical School and the University of Texas Southwestern Medical Center for five years until 2017. Before the Ph.D., he received B.S and M.S. degree from Mechanical Engineering at Seoul National University, Seoul, Korea in 2002 and 2004.

He joined Michigan Tech, Biomedical Engineering from fall 2017, and started Mechanobiology Laboratory. His lab’s interests are in understanding the dynamic nature of force modulation occurring across cell adhesions and cytoskeleton that regulate cells’ environmental sensing. His lab develops a minimally-perturbing experimental approach and computational techniques, including soft-gel fabrication, nano-mechanical tools, live-cell microscopy, and image data modeling, to capture the coupling between force modulation and cellular molecular dynamics.

Sajjad Bigham Named Quarterfinalist in DOE Solar Desalination Prize Contest

Assistant Professor Sajjad Bigham, Mechanical Engineering-Engineering Mechanics, and his team have advanced to the second phase of the American-Made Challenges Solar Desalination Prize contest for his project, “Sorption-Based ZLD Technology.”

The contest is sponsored by the Solar Energy Technologies Office (SETO) at the U.S. Department of Energy (DOE).

Bigham is one of 19 quarterfinalists. Each receives a $50,000 cash prize.

Selected from among 162 applicants, the quarterfinalists now advance to the second, Teaming phase of the competition, for which each research team will develop and successfully validate an operational prototype of their solar-thermal desalination system.

Bigham is a heat transfer and energy systems specialist studying the scientific and engineering challenges at the intersection of thermal-fluid, material and energy sciences.

His Michigan Tech research lab, Energy-X, is focused on understanding the fundamental transport science of important energy carriers at micro, nano and molecular scales. He is a member of the Institute of Computing and Cybersystems’ Center for Cyber-Physical Systems.

Project Title: Sorption-Based ZLD Technology
Location: Houghton, MI
Project Summary: State-of-the-art zero liquid discharge (ZLD) technologies are currently bound with either intensive use of high-grade electrical energy such as mechanical vapor compressors or high capital cost with environmental concerns such as evaporation ponds. A team of researchers from Michigan Technological University, Oak Ridge National Laboratory, and the company Artic Solar proposes to address these issues by an innovative desiccant-based ZLD desalination system in which a multiple-effect distillation (MED) unit is uniquely embedded at the heart of an absorption-desorption system. The technology employs an absorption-based thermally-driven vapor compressor concept to pressurize the vaporized brine of the ZLD crystallizer unit from a low-pressure absorber to a high-pressure desorber module. This eliminates the need for energy-intensive electrically-driven mechanical vapor compressors currently employed in advanced brine crystallizers.

Timely updates about the American-Made Challenges Solar Desalination Prize are posted here.

The American-Made Challenges are a series of prize competitions that incentivize the nation’s entrepreneurs to strengthen American leadership in energy innovation and domestic manufacturing.

The Solar Desalination Prize is a multi-stage prize competition intended to accelerate the development of low-cost desalination systems that use solar-thermal power to produce clean drinking water from saltwater. It is intended to help achieve the goals of the Water Security Grand Challenge.

Each stage of the competition has increasing prize amounts, totaling millions of dollars.