Category: DataS

Driving in the Snow is a Team Effort for AI Sensors

by Allison Mills, University Marketing and Communications

A major challenge for fully autonomous vehicles is navigating bad weather. Snow especially confounds crucial sensor data that helps a vehicle gauge depth, find obstacles and keep on the correct side of the yellow line, assuming it is visible. Averaging more than 200 inches of snow every winter, Michigan’s Keweenaw Peninsula is the perfect place to push autonomous vehicle tech to its limits.

In two papers presented at SPIE Defense + Commercial Sensing 2021, researchers from Michigan Technological University discuss solutions for snowy driving scenarios that could help bring self-driving options to snowy cities like Chicago, Detroit, Minneapolis and Toronto.

The team includes Nathir Rawashdeh and doctoral student Abu-Alrub (CC) as well as Jeremy Bos and student researchers Akhil Kurup, Derek Chopp and Zach Jeffries (ECE).

Read more about their collaborative mobility research on mtu.edu/news.

This MTU news story was published by Science DailyTechXploreKnowridge Science Report and other research news aggregators.

ICC Researcher Profile: Tony Pinar


The Institute of Computing and Cybersystems (ICC) is pleased to welcome Tony Pinar as a member. Pinar’s primary research interests are in applied machine learning and data fusion.

A lecturer in Michigan Tech’s Electrical and Computer Engineering department, Pinar holds a Ph.D. and M.S. in Electrical Engineering from Michigan Tech. His previous positions include research engineer for Michigan Tech’s Advanced Power System Research Center and electrical design engineer for GE Aviation. He is a member of the Institute of Electrical and Electronics Engineers (IEEE) and the IEEE Computational Intelligence Society.

Pinar’s teaching interests include machine learning, signal processing, and electronic design. Included among the classes he teaches are Electronics, Electronic Applications, Probability—Signal Analysis, and Control Systems I.

“Teaching is like a puzzle where one may have to take a difficult concept, reduce it to digestible pieces, and deliver them to fresh minds in a way to maximize understanding and insight,” Pinar says. “That challenge is what drives me to be a better teacher.”

Pinar believes that to be a good teacher one must understand the topics very well and he strives for the most effective delivery. “This keeps me on my toes, forces me to constantly identify holes in my knowledge, and drives me to continuously strive to learn new things,” he explains.

On research, Pinar says it is rewarding to work on open-ended and novel problems that are in their infancy and at the cutting edge of today’s technology.

“It is also exciting to me to watch the cutting edge move forward, see what sticks and what doesn’t, and observe how the direction(s) of the field evolve,” he adds. “I’m very new to this domain so I haven’t been able to observe it for long, but I am looking forward to witnessing the future of the field.”

Conference on Applied Cryptography: Call for Participation


The 2021 EAI International Conference on Applied Cryptography in Computer and Communications (AC3 2021) takes place May 15-16, 2021.

Register for the virtual conference here.

Dr. Bo Chen, Computer Science, founding general chair of the new EAI conference, says the conference has brought together researchers, developers and practitioners from around the world who will focus on, discuss, and explore the area of applied cryptography in computer and communication systems.

Conference Topics

Conference topics include all aspects of applied cryptography, including symmetric cryptography, public-key cryptography, cryptographic protocols, cryptographic implementations, cryptographic standards and practices, as well as using cryptography to solve real-world problems.

Technical Program

The AC3 2021 technical program includes four main conference tracks at which 11 papers will be presented virtually in oral presentations.

  • Track 1 – Blockchain
  • Track 2 – Authentication
  • Track 3 – Secure Computation
  • 4 – Practical Crypto Application. Aside from the high-quality technical paper presentations, the technical program also features two keynote speeches, and one technical workshop.

Keynotes

The two keynote speeches will be delivered by Prof. Kui Ren (ACM Fellow, IEEE Fellow), Zhejiang University, China; and IEEE Fellow Prof. Robert Deng, Singapore Management University.

Workshop

A workshop, the First International Workshop on Security for Internet of Things (IOTS 2021), includes four technical papers which aim to develop cryptographic techniques for ensuring the IoT security. The conference, originally planned to be held in Xiamen China, was moved it online for the health and safety of participants.


Register to participate in the virtual conference here. Use the “Sign up for free access to the livestream” option.


European Alliance for Innovation (EAI) is an international professional community and a nonprofit organization. The goal of EAI is to empower the global ICT research and innovation community, and to promote cooperation between European and International ICT communities.

EAI Conferences span the globe with opportunities to meet, explore, and contribute to the world of ICT research. With 100+ annual events (including MobiQuitous, SecureComm, etc.), EAI is one of the world’s most prolific scientific communities.

EAI Conferences are published via Springer’s LNICST and EAI’s EUDL, and they are indexed in all leading indexing services, including EI, ISI, Scopus, CrossRef, Google Scholar, dblp, MAS, EBSCO, Microsoft Academic Search, CiteSeerX, and more.

Sidike Paheding, AC, Awarded R-D Grant by Purdue University


Sidike Paheding (AC/ICC) is the principal investigator on a project that has received a $19,037 research and development grant from Purdue University. The two-year project is titled, “Cybersecurity Modules Aligned with Undergraduate Computer Science and Engineering Curricula.”

The project aims to serve the national interest by improving how cybersecurity concepts are taught in undergraduate computing curricula.

The grant is a sub-award of a $159,417 Purdue University NSF project . View that project here.


Abstract

This project aims to serve the national interest by improving how cybersecurity concepts are taught in undergraduate computing curricula. The need to design and maintain cyber-secure computing systems is increasingly important. As a result, the future technology workforce must be trained to have a security mindset, so that they consider cybersecurity during rather than after system design. This project aims to achieve this goal by building plug-and-play, hands-on cybersecurity modules for core courses in Computer Engineering, and Computer Science and Engineering. The modules will align with the curricula recommended by the Association for Computing Machinery and will be designed for easy adoption into computing programs nationwide. Modules will be designed for integration into both introductory and advanced courses, thus helping students develop in-depth understanding of cybersecurity as they progress through their computing curriculum. It is expected that the project will encourage more students to pursue careers or higher degrees in the field of cybersecurity.

The project will examine how the modules may be best integrated into existing curricula and the effects of the modules on student learning and interest in cybersecurity. Assessment will leverage several methods including (a) a task load index to quantify rigor, (b) surveys to gain insight into the development of students’ security mindset and perceptions of cybersecurity, and (c) analysis of learning using analytical course rubrics. Deliverables of this project will include a suite of plug-and-play cybersecurity modules for Computer Engineering and Computer Science and Engineering courses that span from introductory to advanced levels and that meet standards for content breadth and depth. The results will be disseminated through publications, presentations, press releases, and social media to ensure that project outcomes are shared widely. The NSF Improving Undergraduate STEM Education: Education and Human Resources Program supports research and development projects to improve the effectiveness of STEM education for all students. Through the Engaged Student Learning track, the program supports the creation, exploration, and implementation of promising practices and tools.

Nathir Rawashdeh Publishes Paper at SPIE Conference

Nathir Rawashdeh (AC) led the publication of a paper at the recent online SPIE Defense + Commercial Sensing / Autonomous Systems 2021 Conference.

The paper, entitled “Drivable path detection using CNN sensor fusion for autonomous driving in the snow,” targets the problem of drivable path detection in poor weather conditions including on snow-covered roads. The authors used artificial intelligence to perform camera, radar and LiDAR sensor fusion to detect a drivable path for a passenger car on snow-covered streets. A companion video is available. 

Co-authors include Jeremy Bos (ECE).

Grad Students Take 6th Place in Navy’s AI Tracks at Sea Challenge

by Karen S. Johnson, Communications Director, College of Computing


The Challenge

Four Michigan Tech graduate students recently took 6th place in the U.S. Navy’s Artificial Intelligence (AI) Tracks at Sea Challenge, receiving a $6,000 prize.

The Challenge solicited software solutions to automatically generate georeferenced tracks of maritime vessel traffic based on data recorded from a single electro-optical camera imaging the traffic from a moving platform.

Each Challenge team was presented with a dataset of recorded camera imagery of vessel traffic, along with the recorded GPS track of a vessel of interest that is seen in the imagery.

Graduate students involved in the challenge were Zach DeKraker and Nicholas Hamilton, both Computer Science majors advised by Tim Havens; Evan Lucas, Electrical Engineering, advised by Zhaohui Wang; and Steven Whitaker, Electrical Engineering.

Submitted solutions were evaluated against additional camera data not included in the competition testing set in order to verify generalization of the solutions. Judging was based on track accuracy (70%) and overall processing time (30%).

“We never got our final score, but we were the “first runner up” team,” says Lucas. “Based on our testing before sending it, we think it worked well most of the time and occasionally tracked a seagull or the wrong boat.”

The total $200,000 prize was distributed among five winning teams, which submitted full working solutions, and three runners-up, which submitted partial working solutions.

The Challenge was sponsored by the Naval Information Warfare Center (NIWC) Pacific and the Naval Science, Technology, Engineering, and Mathematics (STEM) Coordination Office, and managed by the Office of Naval Research. Its goal was to engage with the workforce of tomorrow on challenging and relevant naval problems, with the immediate need to augment unmanned surface vehicles’ (USVs’) maritime contact tracking capability.

The Problem

“The problem presented was to find a particular boat in a video taken of a harbor, and track its GPS coordinates.,” says Zach DeKraker. “We were provided with samples of other videos along with the target boat’s GPS coordinates for that video, which we were able to use to come up with a mapping from pixels to GPS coordinates.”

“Basically, we wanted to track boats with a video camera,” adds ECE graduate student Steven Whitaker. “Our team used machine learning and computer vision to do this. At weekly meetings we brainstormed approaches to tackling the problem, and at regular work sessions, together we programmed it all and produced a white paper with the technical details.”

Whitaker says the competition tied in pretty closely to work the students have already done. “We had a good majority of the code already written. We just needed to fit everything together and add in a few more details and specialize it for the AI Tracks at Sea research,” he explains.

Competitions like this one often connect directly or indirectly with a student’s academic and career goals.

“It’s good to not be pigeon-holed, and to use our knowledge in a different scenario,” Steven Whitaker says of these opportunities. “This helps us remember that there are other things in the world other than our small section of research.”

Dividing Responsibilities

The team knew that there were two primary issues at hand. First, how can the pixel coordinates be translated into GPS coordinates? And second, how can the boat be located so that GPS pixel coordinates can be determined?

“Once we broke it down into these two subproblems, it became pretty clear how to solve each half,” DeKraker says. “Steven had already done a significant amount of work mapping pixel coordinates into GPS coordinates, so we had a pretty quick answer to subproblem one.”

AI Tracks at Sea Flowchart

The team met weekly to discuss their ideas for the project and compare and contrast how effective they would be as solutions to the problem at hand. Then, they got together on Fridays or during the weekends to work together on the project.

“Dr. Havens would come in to our weekly meetings and nudge us in the right direction or give tips on what we should do and what we should avoid,” Whitaker adds.

For subproblem two, after some discussion the group decided it was probably best to use a machine learning approach, as that promised the most significant gains for the least amount of effort, which was important given the tight schedule.

“We tried some different sub-projects independently and then worked together to combine the parts we thought worked best,” Evan Lucas says.

The Solution

To identify the boat and track its movement, the team used a simple neural network and a computer vision technique called optical flow, which made the analysis much faster and cleaner. They used a pre-built algorithm, adding a bit of optical flow so that the boat’s position didn’t have to be verified every time.

AI Tracks at Sea Neural Net Summary

“These two tools allowed us to find the pixel coordinates of the boat and turn them into GPS coordinates,” DeKraker says, whose primary role in the project was integrating the two tools and packaging it for testing.

“Part of my PhD is to map out a snowmobile’s GPS coordinates with a camera,” Whitaker says. “This is extremely similar to mapping out a boat’s GPS coordinates. I could even say that it was exactly the same. I don’t believe I’ll add anything new, but I’ve tweaked it to work for my research.”

Whitaker sums up the team’s division of responsibilities like this: “Evan detects all the boats in the picture; Nik detects which of those boats is our boat; Steven takes our boat position and converts it to GPS coordinates, Zach glued all of our pieces together.”

DeKraker says, “One of the things the judges stressed was the ease of implementing the solution. Since that falls under what I would consider user experience (UX) or user interface (UI), it was pretty natural for me to take these tasks on, having studied software engineering for my undergrad,” DeKraker says.

A primary focus was speed. “Using machine learning for object detection tends to be slow, so to mitigate that we used the boat detector only once every 5 seconds,” DeKraker explains.

“Most of the tracking was done using a very fast technique called optical flow, which looks at the difference between two consecutive frames of a video to track motion,” DeKraker says. “It tended to drift from the target though, so we decided on running the boat detector every 5 seconds to keep optical flow on target. “

“The end result is that our solution could run nearly in real-time,” he says. “The accuracy wasn’t the best, but given a little bit more time and more training data, the neural network could be significantly improved.”

AI Tracks at Sea Homography Transform

Zach DeKraker

DeKraker’s graduate studies focus heavily on various machine learning techniques, He says that this opportunity to integrate machine learning into our solution was a fantastic experience.

“First, it sounded like an interesting challenge. I don’t get to do a lot of software design these days, and this challenge sounded like a great opportunity to do just that,” he explains.

“Second, it looked like a great opportunity to build up my resume a little bit. Saying that you won thousands of dollars for your university in a nationwide competition sounds really good. And finally, I really wanted the chance to see a practical application of machine learning in action.”

DeKraker completed a BS in Software Engineering at Michigan Tech in 2018. He returned to Michigan Tech the next year to complete his master’s degree. He says the biggest reason he did so was to learn more about machine learning.

“Before embarking on this journey, I really didn’t know anything about it,” he says of machine learning. “Having this chance to actually solve a problem, to integrate a neural network into a fully realized boat tracker using nothing but a video helped me see how machine learning can be used practically, rather than merely understanding how it works.”

And although it was a fascinating exploration into the practical side of machine learning and computer vision, DeKraker says it’s rather tangential to his main research focus right now, which is on comparing different network architectures to evaluate which one performs best given particular data and the problem being solved.

DeKraker believes that the culture is the most magnetizing thing about Tech. “Everybody here is cut from the same cloth. We’re all nerds and proud of it,” he explains. “You can have a half-hour conversation with a complete stranger about singularities, the economics of fielding a fleet of star destroyers, or how Sting was forged.”

And the most appealing thing about Michigan Tech was its size. DeKraker says. “When I looked at a ranking of the top universities in Michigan, Tech was number 3, but still extremely small. It was a perfect blend of being a small but very good school.”

And he says the second-best thing about Tech is the location. “The Keweenaw is one of the most beautiful places on earth.”

DeKraker has many ideas about where he’d like to take his career. For instance, he’d love the chance to work for DARPA, Los Alamos National Laboratory, or NASIC. He also intends to commission into the Air Force in the next couple of years, “if they have a place for programmers like me.”

Evan Lucas

Evan Lucas is a PhD candidate in the Electrical Engineering department., advised by Zhaohui Wang. Lucas completed both a bachelor’s and master’s in Mechanical Engineering at Tech in 2012 and 2014,

Lucas, whose research interests are in applying machine learning methods to underwater acoustic communication systems, worked on developing a classifier to separate the boat of interest from the many other boats in the image. Although the subject of the competition is tangential to Lucas’s graduate studies, as computer vision isn’t his area, there was some overlap in general machine learning concepts. respectively.

“It sounded like a fun challenge to put together an entry and learn more about computer vision,” Lucas says. “Working with the rest of the team was a really good opportunity to learn from people who have experience making software that is used by other people.”

Following completion of his doctoral degree, hopefully in spring 2023, Lucas plans to return to industry in a research focused role that applies some of the work he did in his PhD.


Steven Whitaker

Steven Whitaker’s research interests are in machine learning and acoustics. He tracks and locates the position of on-ice vehicles, like snowmobiles, based on acoustics. He says he has used some of the results from this competition project in his PhD research.

Whitaker’s machine learning research is experiment-based., and that’s why he chose Michigan Tech. “There aren’t many opportunities in academia to do experiment-based research,” he says. “Most machine learning is very software-focused using pre-made datasets. I love doing the experiments myself. Research is fun. I enjoy getting paid to do what I normally would do in my free time.”

In 2019, Whitaker completed his BS in Electrical Engineering at Michigan Tech. He expects to complete his master’s degree in Electrical Engineering at the end of the summer 2021 semester, and his PhD in summer 2022. His advisors are Tim Havens and Andrew Barnard.

Whitaker would love to be a university professor one day, but first he wants to work in industry.


Background Info

Timothy Havens is associate dean for research, College of Computing; the William and Gloria Jackson Associate Professor of Computer Systems; and director of the Institute of Computing and Cybersystems (ICC). His research interests are in pattern recognition and machine learning, signal and image processing, sensor and data fusion, heterogeneous data mining, and explosive hazard detection.

Michael Roggeman is a professor in the Electrical and Computer Engineering department. His research interests include optics, image reconstruction and processing, pattern recognition, and adaptive and atmospheric optics.

Zhaohui Wang is an associate professor in the Electrical and Computer Engineering department. Her research interests are in communications, signal processing, communication networks, and network security, with an emphasis on underwater acoustic applications.

The Naval Information Warfare Center (NIWC) Pacific and the Naval Science, Technology, Engineering, and Mathematics (STEM) Coordination Office, managed by the Office of Naval Research are conducting the Artificial Intelligence (AI) Tracks at Sea challenge.

View more details about the Challenge competition here: https://www.challenge.gov/challenge/AI-tracks-at-sea/

Watch a Navy webinar about the Challenge here: https://www.youtube.com/watch?v=MjZwvCX4Tx0.

Challenge.gov is a web platform that assists federal agencies with inviting ideas and solutions directly from the public, or “crowd.” This is called crowdsourcing, and it’s a tenet of the Challenge.gov program. The website enables the U.S. government to engage citizen-solvers in prize competitions for top ideas and concepts as well as breakthrough software, scientific and technology solutions that help achieve their agency missions.

This site also provides a comprehensive toolkit, a robust repository of considerations, best practices, and case studies on running public-sector prize competitions as developed with insights from prize experts across government.

New Course: Applied Machine Learning


Summary

  • Course Number: 84859, EET 4996-01
  • Class Times: T/R, 9:30-10:45 am
  • Location: EERC 0723
  • Instructor: Dr. Sidike Paheding
  • Course Levels: Graduate, Undergraduate
  • Prerequisite: Python Programming and basic knowledge of statistics.
  • Preferred knowledge: Artificial Intelligence (CS 4811) or Data Mining (CS4821) or Intro to Data Sciences (UN 5550)

Course Description/Overview

Rapid growth and remarkable success of machine learning can be witnessed by tremendous advances in technology, contributing to the fields of healthcare, finance, agriculture, energy, education, transportation and more. This course will emphasize on intuition and real-world applications of Machine Learning (ML) rather than statistics behind it. Key concepts of some popular ML techniques, including deep learning, along with hands-on exercises will be provided to students. By the end of this course, students will be able to apply a variety of ML algorithms to practical

Applications Covered

  • Object Detection
  • Digital Recognition
  • Face Recognition
  • Self-Driving Cars
  • Medical Image Segmentation
  • Covid-19 Prediction
  • Spam Email Detection
  • Spectral Signal Categorization

Tools Covered

  • Python
  • scikit learn
  • TensorFlow
  • Keras
  • Open CV
  • pandas
  • matplotlib
  • NumPy
  • seaborn
  • ANACONDA
  • jupyter
  • SPYDER

Download the course description flyer:

Weihua Zhou, CC, to Present Lecture April 8

by Mechanical Engineering-Engineering Mechanics

The net virtual graduate Seminar Speaker will be held at 4 p.m. tomorrow (April 8) via Zoom.

Weihua Zhou (CC) will present “Artificial intelligence for medical image analysis: our approaches. “

Zhou, is an assistant professor of applied computing at Michigan Tech. He has been doing research on medical imaging and informatics since 2008. Attend virtually.

View the University Events Calendar, which includes a registration link and additional information about Dr. Zhou and his research.

Get to Know Dr. Sangyoon Han, Biomedical Engineering


Dr. Sangyoon Han is an assistant professor in Michigan Tech’s Biomedical Engineering department, and an affiliated assistant professor in the Mechanical Engineering-Engineering Mechanics department. He is also advisor to the Korean Students Association. He has been with Michigan Tech since 2017.

Han recently joined the Institute of Computing and Cybersystems and its Data Sciences research group. His primary research interests are in mechanobiology, cell migration, and image data modeling. His research goals include applying computer vision to microscopic images to capture meaningful information, and he’s looking for collaborators.

“Anyone with a good machine learning background is encouraged to contact me to discuss potential research,” he says. “Also, students who learned assignment problems or particle tracking are encouraged to contact me to discuss potential tracking-related projects.”

Teaching and Mentoring

Han’s teaching interests include computer vision for microscopic images, fluid mechanics, cell biomechanics and mechanobiology, and soft tissue mechanics. This academic year, he instructed Computer Vision for Microscopic Images in the Fall semester, and Fluid Mechanics this Spring.

Han enjoys teaching and interacting with students, “and feel their energy, too.” He says he makes a deliberate effort in his classes to pause from time to time so that his students can ask questions.

Han advises two Biomedical Engineering Ph.D. students, Nikhil Mittal and Mohanish Chandurkar.

“Nik is working on finding myosin-independent mechanosensitivity mechanism for stiffness sensing, and Mohanish works on the project finding mechano-transmission for fluid shear stress sensing by endothelial cells,” he says.

Research Aspirations

Han’s Mechanobiology Lab is interested in finding fundamental mechanisms governing mechanotransduction, and how cells sense mechanical forces and convert them into biochemical signals.

“We image cells and associated forces using high-resolution live imaging, which we analyze to obtain statistically meaningful quantity of data,” Han explains. “We apply force-measuring and molecular-imaging/analysis technologies for stiffness sensing, shear flow sensing, adhesion assembly, and cancer mechanobiology.”

Han is working to gain a thorough understanding of the mechano-chemical interaction between cancer cells and their microenvironment, and develop a an effective mechano-therapeutic strategy to stop the progression of cancer, and breast cancer in particular. Ultimately, he wants to apply that knowledge to cancer mechanobiology

Han is principal investigator of a three-year NIH/NIGMS research project, “Nascent Adhesion-Based Mechano-transmission for Extracellular Matrix Stiffness Sensing.” The research aims to determine whether newly-born adhesions can sense tissue stiffness through the accurate measurement of the mechanical force and molecular recruitment of early adhesion proteins.

Some Background

In 2012, Han received his Ph.D. in Mechanical Engineering from the University of Washington in the areas of cell mechanics, multiphysics modeling, and bioMEMS.

For his postdoctoral training, he joined the Computational Cell Biology lab led by Dr. Gaudenz Danuser in the Cell Biology department of Harvard Medical School. In 2014, he joined the UT Southwestern (University of Texas) Department of Cell Biology and Bioinformatics. Han received his B.S and M.S. degrees in mechanical engineering at Seoul National University, Korea, in 2002 and 2004, respectively.

Han holds several patents and in 2015, he developed an open-source TFM (Traction Force Microscopy) Package, which is shared via his lab’s website: hanlab.biomed.mtu.edu/software.

Beyond Research and Teaching

Han loves science and discovering something new in his research investigations. Beyond his work as a professor and scientist, he describes himself as a husband to Sunny, and a dad to his son, Caleb.

“I am just a normal Korean who likes singing and dancing,” he says. “Unfortunately, my voice is still recovering from surgery, but I hope to get back to it soon. I also like to listen to all kinds of music, including hip-hop, classics, and pop.”

He appreciates a good sense of humor, but he says that being humorous in American English is something he continues to learn.

Han says he tries to be “normal” and not too nerd-like when he’s not pursuing his research, but “there are times when I am making my own hypothesis about some phenomena I observe in my daily life.”

Han enjoys life at Michigan Tech and in the Cooper Country. He likes getting to know his energetic students and he finds Michigan Tech faculty members very strong and collegial. He also enjoys the snow, hockey, and the mountains.

“I really like the snow here. I am already sad that the weather is becoming too mild!” he confirms. “It’s also a safe environment to raise kids, which is a big plus.”

And he likes his academic department. “Everyone is so nice in the Biomedical Engineering program, they have been so welcoming and appreciative my research,” Han says. “It’s a family-like environment.”


Active Research

1R15GM135806-01 (09/16/2019 – 08/31/2022)

Funding Agency: NIH/NIGMS

Nascent Adhesion-Based Mechano-transmission for Extracellular Matrix Stiffness Sensing

Project Goals: To determine whether newly-born adhesions can sense tissue stiffness by accurate measurement of mechanical force and of molecular recruitment of early adhesion proteins using traction force microscopy and computer vision techniques.
Role: Principal Investigator


Additional Information

The Mechanobiology Lab studies mechanobiology, particularly how adherent cells can sense and respond to mechanical stiffness of the extracellular matrix. To investigate this, the lab has established experimental and computational frameworks for force measurement and adhesion dynamics quantification. Researchers apply these frameworks, with cutting edge computer vision technique, on live-cell microscope images to investigate the fundamental mechanism underlying mechanosensation in normal cells, and the biomechanical signature of the diseased cells whose signaling has gone awry.

The Institute of Computing and Cybersystems (ICC) creates and supports an arena in which faculty and students work collaboratively across organizational boundaries in an environment that mirrors contemporary technological innovation. The ICC’s 60+ members, in six research centers, represent more than 20 academic disciplines at Michigan Tech. https://www.mtu.edu/icc/

The ICC Center for Data Sciences (DataS) focuses on the research of data sciences education, algorithms, mathematics, and applications. https://www.mtu.edu/icc/centers/data-sciences/

The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation’s medical research agency — making important discoveries that improve health and save lives. https://www.nih.gov/

The National Institute of General Medical Sciences (NIGMS) supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment, and prevention. https://www.nigms.nih.gov/


Recent Publications

  • Han, S. J.; Azarova, E. V.; Whitewood, A. J.; Bachir, A.; Guttierrez, E.; Groisman, A.; Horwitz, A. R.; Goult, B. T.; Dean, K. M.; Danuser, G. Pre-Complexation of Talin and Vinculin without Tension Is Required for Efficient Nascent Adhesion Maturation. eLife 2021, 10, e66151. https://doi.org/10.7554/eLife.66151.
  • Schäfer, C., Ju, Y., Tak, Y., Han, S.J., Tan, E., Shay, J.W., Danuser, G., Holmqvist, M., Bubley, G. (2020) TRA-1-60-positive cells found in the peripheral blood of prostate cancer patients correlate with metastatic disease. Heliyon 6(1), e03263.
  • Isogai, T., Dean, K.M., Roudot, P., Shao, Q., Cillay, J.D., Welf, E.S., Driscoll, M.K., Royer, S.P., Mittal, N., Chang, B., Han, S.J., Fiolka, R., Danuser, G., Direct Arp2/3-vinculin binding is essential for cell spreading, but only on compliant substrates and in 3D, BioRxiv, 2019
  • Mohan, A.S., Dean, K.M., Isogai, T., Kasitinon, S.Y., Murali, V.S., Roudot, P., Groisman, A., Reed, D.K., Welf, E.S., Han, S.J., Noh, J., and Danuser, G. (2019). Enhanced Dendritic Actin Network Formation in Extended Lamellipodia Drives Proliferation in Growth-Challenged Rac1P29S Melanoma Cells. Developmental Cell, 49(3), pp.444-460.
  • Manifacier I., Milan, J., Beussman, K., Han, S.J., Sniadecki, N.J., About, I (2019) The consequence of large-scale rigidity on actin network tension. In press. Comp Meth Biomech Biomed Eng, 2019 Oct;22(13):1073-1082.
  • Costigliola, N., Ding, L., Burckhardt, C.J., Han, S.J., Gutierrez, E., Mota, A., Groisman, A., Mitchison, T.J., and Danuser, G. (2017) Vimentin directs traction stress. PNAS2017 114 (20) 5195-5200.
  • Han, S.J., Rodriguez M.L., Al-Rekabi, Z., Sniadecki, N.J. (2016) Spatial and Temporal Coordination of Traction Forces in One-Dimensional Cell Migration, Cell Adhesion & Migration. 10(5): 529-539.
  • Oudin, M.J., Barbier, L., Schäfer, C, Kosciuk, T., Miller, M.A., Han, S.J., Jonas, O., Lauffenburger, D.A., Gertler, F.B. (2016) Mena confers resistance to Paclitaxel in triple-negative breast cancer. Mol Cancer Ther.DOI: 10.1158/1535-7163. MCT-16-0413. 
  • Milan,J., Manifacier, I., Beussman, K.M., Han, S.J., Sniadecki, N.J., About, I., Chabrand, P. (2016) In silico CDM model sheds light on force transmission in cell from focal adhesions to nucleus. J Biomechanics. 49(13):2625-2634. 
  • Lomakin. A.J., Lee, K.C., Han, S.J., Bui, A., Davidson, M., Mogilner, A., Danuser G. (2015) Competition for molecular resources among two structurally distinct actin networks defines a bistable switch for cell polarization, Nature Cell Biology. 17, 1435–1445
  • Han, S.J., Oak, Y., Groisman, A., Danuser, G. (2015) Traction Microscopy to Identify Force Modulation in Sub-resolution Adhesions, Nature Methods. 12(7): 653–656